{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:45:30Z","timestamp":1793357130617,"version":"4.5.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/spniprfge0do","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["GFI"],"award-info":[{"award-number":["GFI"]}],"id":[{"id":"10.13039\/spniprfge0do","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/spniprfge0do","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["Grant for internalization"],"award-info":[{"award-number":["Grant for internalization"]}],"id":[{"id":"10.13039\/spniprfge0do","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/speugfqpeyrf","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca, PRIN 2022","doi-asserted-by":"publisher","award":["Prot. 2022PF4NCA. to Vincenzo Cantaluppi"],"award-info":[{"award-number":["Prot. 2022PF4NCA. to Vincenzo Cantaluppi"]}],"id":[{"id":"10.13039\/speugfqpeyrf","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Surface expression of stage-specific embryonic antigen 4 on urinary extracellular vesicles and CD42a on plasma extracellular vesicles identified distinct recovery trajectories after AKI.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A combined urinary\u2013plasma extracellular vesicle index enhanced prognostic performance.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These findings highlight extracellular vesicle surface profiling as a potential minimally invasive liquid biopsy strategy to monitor post-AKI repair.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Maladaptive repair processes after AKI can promote the progression of CKD, highlighting the need for biomarkers capable of monitoring post-AKI renal function trajectory. Extracellular vesicles (EVs), nanosized lipid vesicles secreted by cells into biofluids, are considered valuable biomarker sources, as their cargo may reflect the originating cells and their pathophysiologic condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Urinary EV (uEV) and plasma EV surface markers were analyzed in patients with AKI compared with age- and sex-matched controls using multiplex flow cytometry. Patients were stratified according to renal function changes at 90-day follow-up, distinguishing between those with an improved or not-improved kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In patients with AKI at hospital discharge, uEV analysis showed a downregulation of the tubular progenitor markers CD133 and CD24, with upregulation of mesenchymal\/inflammatory markers CD29, stage-specific embryonic antigen 4 (SSEA-4), and HLA-DR, in comparison with controls. Plasma EV analysis showed concomitant modulation in patients with AKI of markers of endothelial dysfunction and platelet activation. Considering kidney function at 90 days of follow-up, uEVSSEA-4, a marker of cell dedifferentiation, was higher in patients with AKI with improved function and correlated with renal recovery. Conversely, plasma EV CD42a, a marker of platelet activation, was higher in patients with persistent renal impairment and negatively correlated with renal recovery. Furthermore, the combined urinary SSEA4\/plasma EV-associated CD42a index provided higher correlation and regression performance compared with either marker alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that EV surface profiling could represent a minimally invasive strategy to distinguish adaptive from maladaptive repair after AKI, supporting the potential use of integrated uEV and plasma EV biomarkers to predict kidney disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Podcast<\/jats:title>\n                    <jats:p>This article contains a podcast at https:\/\/dts.podtrac.com\/redirect.mp3\/www.asn-online.org\/media\/podcast\/K360\/2026_10_29_KID0000001331.mp3<\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0000001331","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:02:09Z","timestamp":1786982529000},"page":"2175-2185","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Urine and Plasma Extracellular Vesicle Analysis for Monitoring Renal Recovery after Acute Kidney Injury"],"prefix":"10.34067","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3131-8359","authenticated-orcid":false,"given":"Adele","family":"Tanzi","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6960-5476","authenticated-orcid":false,"given":"Cristina","family":"Grange","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4919-3133","authenticated-orcid":false,"given":"Miriam","family":"Rosina","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Piemonte Orientale (UPO), Novara, Italy"},{"name":"Nephrology and Kidney Transplantation Unit, \u201cMaggiore della Carit\u00e0\u201d University Hospital, University of Piemonte Orientale (UPO), Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5973-5007","authenticated-orcid":false,"given":"Alessia","family":"Brossa","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7884-7314","authenticated-orcid":false,"given":"Jacopo","family":"Burrello","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6297-8010","authenticated-orcid":false,"given":"Sarah","family":"Tassinari","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Prenna","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Piemonte Orientale (UPO), Novara, Italy"},{"name":"Nephrology and Kidney Transplantation Unit, \u201cMaggiore della Carit\u00e0\u201d University Hospital, University of Piemonte Orientale (UPO), Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Piscia","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Piemonte Orientale (UPO), Novara, Italy"},{"name":"Nephrology and Kidney Transplantation Unit, \u201cMaggiore della Carit\u00e0\u201d University Hospital, University of Piemonte Orientale (UPO), Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-3884","authenticated-orcid":false,"given":"Valentina","family":"Bettio","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Piemonte Orientale (UPO), Novara, Italy"},{"name":"UPO Biobank, University of Piemonte Orientale (UPO), Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9157-8753","authenticated-orcid":false,"given":"Daniela","family":"Capello","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Piemonte Orientale (UPO), Novara, Italy"},{"name":"UPO Biobank, University of Piemonte Orientale (UPO), Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-4106","authenticated-orcid":false,"given":"Marita","family":"Marengo","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, ASL CN 1, Cuneo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Cantaluppi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Piemonte Orientale (UPO), Novara, Italy"},{"name":"Nephrology and Kidney Transplantation Unit, \u201cMaggiore della Carit\u00e0\u201d University Hospital, University of Piemonte Orientale (UPO), Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3663-5134","authenticated-orcid":false,"given":"Benedetta","family":"Bussolati","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"10212","key":"B1-20261029","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(19)32563-2","article-title":"Acute kidney injury","volume":"394","author":"Ronco","year":"2019","journal-title":"Lancet."},{"issue":"5","key":"B2-20261029","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/ki.2012.208","article-title":"Acute kidney injury and chronic kidney disease: an integrated clinical syndrome","volume":"82","author":"Chawla","year":"2012","journal-title":"Kidney Int."},{"issue":"1","key":"B3-20261029","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1681\/ASN.2012080800","article-title":"Temporal changes in incidence of dialysis-requiring AKI","volume":"24","author":"Hsu","year":"2013","journal-title":"J Am Soc Nephrol."},{"issue":"4","key":"B4-20261029","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrneph.2017.2","article-title":"Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 workgroup","volume":"13","author":"Chawla","year":"2017","journal-title":"Nat Rev Nephrol."},{"issue":"1","key":"B5-20261029","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1056\/NEJMra1214243","article-title":"Acute kidney injury and chronic kidney disease as interconnected syndromes","volume":"371","author":"Chawla","year":"2014","journal-title":"N Engl J Med."},{"issue":"5","key":"B6-20261029","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.kint.2017.06.030","article-title":"AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms","volume":"92","author":"He","year":"2017","journal-title":"Kidney Int."},{"issue":"1","key":"B7-20261029","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa1114248","article-title":"Estimating glomerular filtration rate from serum creatinine and cystatin C","volume":"367","author":"Inker","year":"2012","journal-title":"N Engl J Med."},{"key":"B8-20261029","doi-asserted-by":"crossref","first-page":"8897833","DOI":"10.1155\/2020\/8897833","article-title":"Exosomes in nephropathies: a rich source of novel biomarkers","volume":"2020","author":"Masaoutis","year":"2020","journal-title":"Dis Markers."},{"issue":"19","key":"B9-20261029","doi-asserted-by":"crossref","first-page":"6424","DOI":"10.3390\/jcm12196424","article-title":"Renal biopsy for diagnosis in kidney disease: indication, technique, and safety","volume":"12","author":"Schnuelle","year":"2023","journal-title":"J Clin Med."},{"issue":"2","key":"B10-20261029","doi-asserted-by":"crossref","first-page":"e12404","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J Extracell Vesicles."},{"issue":"1","key":"B11-20261029","doi-asserted-by":"crossref","first-page":"e12181","DOI":"10.1002\/jev2.12181","article-title":"Nephron mass determines the excretion rate of urinary extracellular vesicles","volume":"11","author":"Blijdorp","year":"2022","journal-title":"J Extracell Vesicles."},{"issue":"1","key":"B12-20261029","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat Cell Biol."},{"issue":"7","key":"B13-20261029","doi-asserted-by":"crossref","first-page":"e70120","DOI":"10.1002\/jev2.70120","article-title":"Roadblocks of urinary EV biomarkers: moving toward the clinic","volume":"14","author":"Droste","year":"2025","journal-title":"J Extracell Vesicles."},{"issue":"1","key":"B14-20261029","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12964-023-01089-1","article-title":"Protein corona and exosomes: new challenges and prospects","volume":"21","author":"Heidarzadeh","year":"2023","journal-title":"Cell Commun Signal."},{"issue":"7","key":"B15-20261029","doi-asserted-by":"crossref","first-page":"e12093","DOI":"10.1002\/jev2.12093","article-title":"Urinary extracellular vesicles: a position paper by the urine task force of the International Society for Extracellular Vesicles","volume":"10","author":"Erdbr\u00fcgger","year":"2021","journal-title":"J Extracell Vesicles."},{"issue":"2","key":"B16-20261029","doi-asserted-by":"crossref","first-page":"e12304","DOI":"10.1002\/jev2.12304","article-title":"An in vitro approach to understand contribution of kidney cells to human urinary extracellular vesicles","volume":"12","author":"Barreiro","year":"2023","journal-title":"J Extracell Vesicles."},{"issue":"36","key":"B17-20261029","doi-asserted-by":"crossref","first-page":"13368","DOI":"10.1073\/pnas.0403453101","article-title":"Identification and proteomic profiling of exosomes in human urine","volume":"101","author":"Pisitkun","year":"2004","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"5","key":"B18-20261029","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/ki.2013.422","article-title":"Subfractionation, characterization, and in-depth proteomic analysis of glomerular membrane vesicles in human urine","volume":"85","author":"Hogan","year":"2014","journal-title":"Kidney Int."},{"issue":"8","key":"B19-20261029","doi-asserted-by":"crossref","first-page":"e104490","DOI":"10.1371\/journal.pone.0104490","article-title":"Urinary CD133+ extracellular vesicles are decreased in kidney transplanted patients with slow graft function and vascular damage","volume":"9","author":"Dimuccio","year":"2014","journal-title":"PLoS One."},{"issue":"9","key":"B20-20261029","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.3390\/biom14091124","article-title":"Urinary extracellular vesicles for non-invasive quantification of principal cell damage in kidney transplant recipients","volume":"14","author":"Svenningsen","year":"2024","journal-title":"Biomolecules."},{"issue":"8","key":"B21-20261029","doi-asserted-by":"crossref","first-page":"eaeb0555","DOI":"10.1126\/sciadv.aeb0555","article-title":"Glomerular routing of tumor-derived extracellular vesicles substantiates urinary biopsy","volume":"12","author":"Kawaguchi","year":"2026","journal-title":"Sci Adv."},{"issue":"7","key":"B22-20261029","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s10157-024-02464-z","article-title":"Detecting and exploring kidney-derived extracellular vesicles in plasma","volume":"28","author":"Komatsu","year":"2024","journal-title":"Clin Exp Nephrol."},{"key":"B23-20261029","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/bs.acc.2021.02.002","article-title":"Extracellular vesicles: potential impact on cardiovascular diseases","volume":"105","author":"Yang","year":"2021","journal-title":"Adv Clin Chem."},{"issue":"6","key":"B24-20261029","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1053\/j.ajkd.2018.03.028","article-title":"Distant organ dysfunction in acute kidney injury: a review","volume":"72","author":"Lee","year":"2018","journal-title":"Am J Kidney Dis."},{"issue":"2","key":"B25-20261029","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0002-9440(10)62276-6","article-title":"Isolation of renal progenitor cells from adult human kidney","volume":"166","author":"Bussolati","year":"2005","journal-title":"Am J Pathol."},{"issue":"10","key":"B26-20261029","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/s41581-018-0057-8","article-title":"HLA and kidney disease: from associations to mechanisms","volume":"14","author":"Robson","year":"2018","journal-title":"Nat Rev Nephrol."},{"issue":"3","key":"B27-20261029","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/oxfordjournals.ndt.a091857","article-title":"HLA-DR display by renal tubular epithelium and phenotype of infiltrate in interstitial nephritis","volume":"4","author":"Cheng","year":"1989","journal-title":"Nephrol Dial Transplant."},{"issue":"1","key":"B28-20261029","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tvjl.2013.06.006","article-title":"De novo expression of human leukocyte antigen-DR (HLA-DR) and loss of beta-catenin expression in tubular epithelial cells: a possible event in epithelial-mesenchymal transition in canine renal diseases","volume":"198","author":"Benali","year":"2013","journal-title":"Vet J."},{"issue":"4","key":"B29-20261029","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1182\/blood-2005-11-010504","article-title":"SSEA-4 identifies mesenchymal stem cells from bone marrow","volume":"109","author":"Gang","year":"2007","journal-title":"Blood."},{"issue":"5","key":"B30-20261029","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/cyto.a.24726","article-title":"Pluripotent stem cells: basic biology or else differentiations aimed at translational research and the role of flow cytometry","volume":"103","author":"Bose","year":"2023","journal-title":"Cytometry A."},{"issue":"3","key":"B31-20261029","doi-asserted-by":"crossref","first-page":"szaf002","DOI":"10.1093\/stcltm\/szaf002","article-title":"Unveiling spontaneous renal tubule-like structures from human adult renal progenitor cell spheroids derived from urine","volume":"14","author":"Giannuzzi","year":"2025","journal-title":"Stem Cell Transl Med."},{"issue":"6","key":"B32-20261029","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00134-017-4691-6","article-title":"Understanding renal functional reserve","volume":"43","author":"Ronco","year":"2017","journal-title":"Intensive Care Med."},{"issue":"10521","key":"B33-20261029","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1016\/S0140-6736(25)01717-9","article-title":"A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial","volume":"406","author":"Zarbock","year":"2025","journal-title":"Lancet."},{"issue":"2","key":"B34-20261029","doi-asserted-by":"crossref","first-page":"F486","DOI":"10.1152\/ajprenal.00404.2019","article-title":"Acute and chronic glomerular damage is associated with reduced CD133 expression in urinary extracellular vesicles","volume":"318","author":"Dimuccio","year":"2020","journal-title":"Am J Physiol Renal Physiol."},{"issue":"8","key":"B35-20261029","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1097\/TP.0b013e31816a8891","article-title":"Increase of proliferating renal progenitor cells in acute tubular necrosis underlying delayed graft function","volume":"85","author":"Loverre","year":"2008","journal-title":"Transplantation."},{"issue":"1","key":"B36-20261029","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.kint.2017.07.030","article-title":"Cellular and molecular pathways of renal repair after acute kidney injury","volume":"93","author":"Kumar","year":"2018","journal-title":"Kidney Int."},{"issue":"3","key":"B37-20261029","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/sctm.17-0158","article-title":"Role of CD133 molecule in Wnt response and renal repair","volume":"7","author":"Brossa","year":"2018","journal-title":"Stem Cell Transl Med."},{"issue":"1","key":"B38-20261029","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12951-025-03102-w","article-title":"Prominosomes - a particular class of extracellular vesicles containing prominin-1\/CD133?","volume":"23","author":"Karbanov\u00e1","year":"2025","journal-title":"J Nanobiotechnology."},{"issue":"1","key":"B39-20261029","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41514-024-00189-7","article-title":"Age- and sex-related variations in extracellular vesicle profiling for the assessment of cardiovascular risk: the EVaging index","volume":"10","author":"Burrello","year":"2024","journal-title":"NPJ Aging."},{"issue":"7","key":"B40-20261029","doi-asserted-by":"crossref","first-page":"102596","DOI":"10.1016\/j.rpth.2024.102596","article-title":"Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy","volume":"8","author":"Tobiasch","year":"2024","journal-title":"Res Pract Thromb Haemost."},{"issue":"3","key":"B41-20261029","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/ndt\/gfac259","article-title":"Identification of a serum and urine extracellular vesicle signature predicting renal outcome after kidney transplant","volume":"38","author":"Burrello","year":"2023","journal-title":"Nephrol Dial Transplant."},{"issue":"9","key":"B42-20261029","doi-asserted-by":"crossref","first-page":"e167731","DOI":"10.1172\/jci.insight.167731","article-title":"Longitudinal biomarkers and kidney disease progression after acute kidney injury","volume":"8","author":"Wen","year":"2023","journal-title":"JCI Insight."}],"container-title":["Kidney360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0000001331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:00:31Z","timestamp":1793311231000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0000001331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.34067\/kid.0000001331","relation":{},"ISSN":["2641-7650","2641-7650"],"issn-type":[{"value":"2641-7650","type":"electronic"},{"value":"2641-7650","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"2026-03-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}