{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:54:24Z","timestamp":1787838864809,"version":"build-2784847793"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK-102085"],"award-info":[{"award-number":["DK-102085"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX001958"],"award-info":[{"award-number":["I01 BX001958"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015502","name":"Dialysis Clinic, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015502","id-type":"DOI","asserted-by":"crossref"}]},{"name":"New Mexico Brain & Behavioral Health Institute","award":["2018-1008"],"award-info":[{"award-number":["2018-1008"]}]},{"name":"Center for Integrative Nanotechnology","award":["2019AU0120"],"award-info":[{"award-number":["2019AU0120"]}]},{"name":"Autophagy, Inflammation, and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, New Mexico","award":["NIH grant P20GM121176"],"award-info":[{"award-number":["NIH grant P20GM121176"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Gadolinium-based contrast agents (GBCAs) have provided much needed image enhancement in magnetic resonance imaging (MRI) important in the advancement of disease diagnosis and treatment. The paramagnetic properties of ionized gadolinium have facilitated these advancements, but ionized gadolinium carries toxicity risk. GBCAs were formulated with organic chelates designed to reduce these toxicity risks from unbound gadolinium ions. They were preferred over iodinated contrast used in computed tomography and considered safe for use. As their use expanded, the development of new diseases associated with their use (including nephrogenic systemic fibrosis) has drawn more attention and ultimately caution with their clinical administration in those with impaired renal function. Use of GBCAs in those with preserved renal function was considered to be safe. However, in this new era with emerging clinical and experimental evidence of brain gadolinium deposition in those with repeated exposure, these safety assumptions are once again brought into question. This review article aims to add new perspectives in thinking about the role of GBCA in current clinical use. The new information begs for further discussion and consideration of the risk-benefit ratio of use of GBCAs.<\/jats:p>","DOI":"10.34067\/kid.0000272019","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T21:45:23Z","timestamp":1586987123000},"page":"561-568","source":"Crossref","is-referenced-by-count":115,"title":["Gadolinium-Based Contrast Agent Use, Their Safety, and Practice Evolution"],"prefix":"10.34067","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9688-1820","authenticated-orcid":false,"given":"Catherine","family":"Do","sequence":"first","affiliation":[{"name":"Kidney Institute of New Mexico, Albuquerque, New Mexico"},{"name":"Renal Section, Medicine Service, New Mexico Veterans Administration Health Care System, Albuquerque, New Mexico"},{"name":"Department of Medicine, University of New Mexico Health Care System, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6821-2067","authenticated-orcid":false,"given":"Joshua","family":"DeAguero","sequence":"additional","affiliation":[{"name":"Kidney Institute of New Mexico, Albuquerque, New Mexico"},{"name":"University of New Mexico Health Sciences Center, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7364-8815","authenticated-orcid":false,"given":"Adrian","family":"Brearley","sequence":"additional","affiliation":[{"name":"Department of Earth and Planetary Science, University of New Mexico, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xochitl","family":"Trejo","sequence":"additional","affiliation":[{"name":"Sandia High School, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Howard","sequence":"additional","affiliation":[{"name":"University of New Mexico Health Sciences Center, Albuquerque, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4505-5297","authenticated-orcid":false,"given":"G. 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