{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:29:51Z","timestamp":1786480191074,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","funder":[{"DOI":"10.13039\/501100003389","name":"Fresenius Medical Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003389","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The hemocompatibility of dialyzers for extracorporeal kidney replacement therapy (KRT) is of importance to minimize harmful reactions between blood constituents and the membrane. We investigated in these exploratory studies the hemocompatibility profile of several types of polysulfone dialyzers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Hemocompatibility of various high-flux polysulfone dialyzers were compared in two consecutive, prospective, randomized, crossover studies, each including 24 adult patients being at least 3 months on hemodialysis (HD) or on-line hemodiafiltration (HDF). These dialyzers, differing in membrane type, fiber geometry, sterilization method, and production technology, were each applied for 1 week in HD or HDF. Hemocompatibility was assessed through markers of complement activation, cell activation, coagulation, contact activation, and immunologic reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patients in the two studies were on average 67\u00b111 and 68\u00b111 years old, 75% and 67% were male, and were on KRT for 5.4\u00b15.0 and 4.4\u00b13.6 years. The complement factors C3a and C5a increased early and transiently during treatment, less so with HDF than with HD, and with dialyzers combining wider inner fiber diameter (210 versus 185\n                      <jats:italic toggle=\"yes\">\u00b5<\/jats:italic>\n                      m) and advanced membrane type (Helixone plus versus Helixone). sC5b-9 increased in all study phases, reaching its highest level after 60 minutes, with lower values over the entire treatment (area under the curve) for HDF than HD, and for wider inner fiber diameter and advanced membrane type. Leukocytes decreased in the first 10 minutes, without significant differences between dialyzers. PMN elastase increased in the first hour, more so with HD than HDF. Thrombocytes decreased slightly in the first 30 minutes, with differences only between HDF and HD mode. IL-8 decreased from pre- to postdialysis, particularly on HDF. No differences were observed for kallikrein, IgE, and hsCRP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In these explorative studies we found indications to a comparable hemocompatibility profile of the investigated dialyzers. We observed distinctions in compounds between HDF and HD and for some dialyzer and membrane characteristics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0000342019","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T18:20:47Z","timestamp":1582050047000},"page":"25-35","source":"Crossref","is-referenced-by-count":11,"title":["Hemocompatibility of Polysulfone Hemodialyzers \u2013 Exploratory Studies on Impact of Treatment Modality and Dialyzer Characteristics"],"prefix":"10.34067","volume":"1","author":[{"given":"Stephan","family":"Wagner","sequence":"first","affiliation":[{"name":"Center for Kidney and Blood Pressure Diseases, Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Zsch\u00e4tzsch","sequence":"additional","affiliation":[{"name":"Center for Kidney and Blood Pressure Diseases, Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Erlenkoetter","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Deutschland GmbH, Global Research and Development, St. Wendel, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Rauber","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Deutschland GmbH, Global Research and Development, St. Wendel, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Stauss-Grabo","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Deutschland GmbH, EMEA Medical Office, Bad Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2554-0711","authenticated-orcid":false,"given":"Adelheid","family":"Gauly","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Deutschland GmbH, EMEA Medical Office, Bad Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,1,30]]},"reference":[{"key":"B1-20230821","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1681\/ASN.2008060590","article-title":"Effect of membrane permeability on survival of hemodialysis patients","volume":"20","author":"Locatelli","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"B2-20230821","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1681\/ASN.2012080875","article-title":"High-efficiency postdilution online hemodiafiltration reduces all-cause mortality in hemodialysis patients","volume":"24","author":"Maduell","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"B3-20230821","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/ndt\/gfv349","article-title":"Haemodiafiltration and mortality in end-stage kidney disease patients: A pooled individual participant data analysis from four randomized controlled trials","volume":"31","author":"Peters","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"B4-20230821","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1046\/j.1523-1755.2003.00924.x","article-title":"Review on uremic toxins: Classification, concentration, and interindividual variability","volume":"63","author":"Vanholder","year":"2003","journal-title":"Kidney Int"},{"key":"B5-20230821","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1681\/ASN.2005020132","article-title":"Serum beta-2 microglobulin levels predict mortality in dialysis patients: Results of the HEMO study","volume":"17","author":"Cheung","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"B6-20230821","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/ndt\/gfs407","article-title":"Mortality and cardiovascular events in online haemodiafiltration (OL-HDF) compared with high-flux dialysis: Results from the Turkish OL-HDF Study","volume":"28","author":"Ok","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"B7-20230821","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1681\/ASN.2011121140","article-title":"Effect of online hemodiafiltration on all-cause mortality and cardiovascular outcomes","volume":"23","author":"Grooteman","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"B8-20230821","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/ndt\/14.5.1176","article-title":"Effect of permeability on indices of haemodialysis membrane biocompatibility","volume":"14","author":"Masaki","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"B9-20230821","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000169480","article-title":"Leukocytes, eosinophils and complement function during hemodialysis with polysulphone and polymethylmethacrylate membranes: Comparison with cuprophan and polyacrylonitrile","volume":"6","author":"Bergesio","year":"1988","journal-title":"Blood Purif"},{"issue":"Suppl 2","key":"B10-20230821","first-page":"55","article-title":"Biocompatibility of dialysis membranes: A comparative study","volume":"6","author":"Martin-Malo","year":"1991","journal-title":"Nephrol Dial Transplant"},{"key":"B11-20230821","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00002480-199541020-00018","article-title":"Biocompatibility and performance of a modified cellulosic and a synthetic high flux dialyzer. 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