{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:30:14Z","timestamp":1786480214641,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>\n                    Cerebral edema, in a variety of circumstances, may be accompanied by states of hyponatremia. The threat of brain injury from hypotonic stress-induced astrocyte demyelination is more common when vulnerable patients with hyponatremia who have end stage liver disease, traumatic brain injury, heart failure, or other conditions undergo overly rapid correction of hyponatremia. These scenarios, in the context of declining urinary output from CKD and\/or AKI, may require controlled elevations of plasma tonicity\n                    <jats:italic toggle=\"yes\">vis-\u00e0-vis<\/jats:italic>\n                    increases of the plasma sodium concentration. We offer a strategic solution to this problem\n                    <jats:italic toggle=\"yes\">via<\/jats:italic>\n                    sodium-based osmotherapy applied through a conventional continuous RRT modality: predilution continuous venovenous hemofiltration.\n                  <\/jats:p>","DOI":"10.34067\/kid.0000382019","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T18:14:21Z","timestamp":1582740861000},"page":"281-291","source":"Crossref","is-referenced-by-count":11,"title":["Sodium-Based Osmotherapy in Continuous Renal Replacement Therapy: a Mathematical Approach"],"prefix":"10.34067","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8231-0568","authenticated-orcid":false,"given":"Jerry","family":"Yee","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, Michigan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naushaba","family":"Mohiuddin","sequence":"additional","affiliation":[{"name":"St. Clair Specialty Physicians, Roseville, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor","family":"Gradinariu","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, Michigan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junior","family":"Uduman","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, Michigan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Frinak","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, Michigan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"B1-20230821","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fmed.2018.00103","article-title":"Using electrolyte free water balance to rationalize and treat dysnatremias","volume":"5","author":"Shah","year":"2018","journal-title":"Front Med (Lausanne)"},{"key":"B2-20230821","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0002-9343(86)90401-8","article-title":"New approach to disturbances in the plasma sodium concentration","volume":"81","author":"Rose","year":"1986","journal-title":"Am J Med"},{"key":"B4-20230821","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1002\/hep.22846","article-title":"Impact of pretransplant hyponatremia on outcome following liver transplantation","volume":"49","author":"Yun","year":"2009","journal-title":"Hepatology"},{"key":"B5-20230821","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.aohep.2019.01.004","article-title":"Occult central pontine myelinolysis post liver transplant: A consequence of pre-transplant hyponatremia","volume":"18","author":"Zhu","year":"2019","journal-title":"Ann Hepatol"},{"key":"B6-20230821","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11154-019-09483-2","article-title":"Therapeutic hypernatremia management during continuous renal replacement therapy with elevated intracranial pressures and respiratory failure [published correction appears in Rev Endocr Metab Disord 20: 77, 2019]","volume":"20","author":"F\u00fcl\u00f6p","year":"2019","journal-title":"Rev Endocr Metab Disord"},{"key":"B7-20230821","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/0885066613487151","article-title":"Hypertonic saline in elevated intracranial pressure: Past, present, and future","volume":"30","author":"Surani","year":"2015","journal-title":"J Intensive Care Med"},{"key":"B8-20230821","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1681\/ASN.2016101139","article-title":"Diagnosis and treatment of hyponatremia: Compilation of the guidelines","volume":"28","author":"Hoorn","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B9-20230821","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1525-139X.2011.00981.x","article-title":"A proposed approach to the dialysis prescription in severely hyponatremic patients with end-stage renal disease","volume":"25","author":"Wendland","year":"2012","journal-title":"Semin Dial"},{"key":"B10-20230821","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/hdi.12572","article-title":"High sodium continuous veno-venous hemodialysis with regional citrate anticoagulation and online dialysate generation in patients with acute liver failure and cerebral edema","volume":"22","author":"Hamdi","year":"2018","journal-title":"Hemodial Int"},{"key":"B11-20230821","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0272-6386(98)70141-6","article-title":"Successful treatment of severe hyponatremia in a patient with renal failure using continuous venovenous hemodialysis","volume":"32","author":"Bender","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"B12-20230821","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1053\/j.ajkd.2014.01.451","article-title":"Treatment of severe hyponatremia in patients with kidney failure: Role of continuous venovenous hemofiltration with low-sodium replacement fluid","volume":"64","author":"Yessayan","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"B13-20230821","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1159\/000355397","article-title":"Successful treatment of extreme hyponatremia in an anuric patient using continuous venovenous hemodialysis","volume":"36","author":"Viktorsdottir","year":"2013","journal-title":"Blood Purif"},{"key":"B14-20230821","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2215\/CJN.13281117","article-title":"Management of severe hyponatremia with continuous renal replacement therapies","volume":"13","author":"Rosner","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"B15-20230821","first-page":"35","article-title":"The analysis of concentration dependence of uremic lesions in clinical studies","volume":"7","author":"Sargent","year":"1975","journal-title":"Kidney Int Suppl"},{"issue":"Suppl 1","key":"B16-20230821","first-page":"S7","article-title":"I. 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