{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:30:17Z","timestamp":1786480217840,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","funder":[{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2020,4]]},"abstract":"\n Background<\/jats:title>\n The incidence of venous thromboembolism (VTE) is increased in ANCA-associated vasculitis (AAV). We assessed the frequency of VTE observed among patients with AAV evaluated at our center and identified risk factors.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients from the Johns Hopkins Vasculitis Center cohort who were evaluated between 1998 and 2018 and had a diagnosis of granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) were eligible for analysis. Baseline demographics and clinical and serologic data were extracted. Univariate and multivariate analyses were performed to identify factors associated with VTE in AAV.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 162 patients with AAV were identified, 105 (65%) with GPA; 22 (14%) of these patients had a recorded VTE with a median time to VTE of 1 month. The mean (SD) age in the VTE versus non-VTE groups was 54\u00b120 versus 55\u00b117 years (\n P<\/jats:italic>\n =0.99), 64% versus 60% female (\n P<\/jats:italic>\n =0.93), 82% versus 49% PR3-ANCA positive (\n P<\/jats:italic>\n =0.01), with a total mean BMI of 33.3\u00b15.7 versus 28.3\u00b16.1 kg\/m\n 2<\/jats:sup>\n , (\n P<\/jats:italic>\n <0.001) respectively. The median Birmingham Vasculitis Activity Score (BVAS version 3) was 19 versus 14 (\n P<\/jats:italic>\n =0.02). Univariate analyses identified PR3-ANCA, rapidly progressive GN (RPGN), and hypoalbuminemia. In multivariate analysis, the significant associations with VTE included PR3-ANCA (OR, 4.77;\n P<\/jats:italic>\n =0.02), hypoalbuminemia (OR, 4.84;\n P<\/jats:italic>\n =0.004), and BMI (OR, 1.18;\n P<\/jats:italic>\n <0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n VTE is a surprisingly common complication of AAV. PR3-ANCA and hypoalbuminemia are risk factors for developing VTEs. Further studies are needed to confirm these findings.<\/jats:p>\n <\/jats:sec>\n \n Podcast<\/jats:title>\n This article contains a podcast at https:\/\/www.asn-online.org\/media\/podcast\/K360\/2020_04_30_KID0000572019.mp3<\/jats:p>\n <\/jats:sec>","DOI":"10.34067\/kid.0000572019","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T16:25:11Z","timestamp":1583252711000},"page":"258-262","source":"Crossref","is-referenced-by-count":13,"title":["Venous Thrombotic Events in ANCA-Associated Vasculitis: Incidence and Risk Factors"],"prefix":"10.34067","volume":"1","author":[{"given":"Bradley","family":"Isaacs","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Gapud","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Antiochos","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8353-5542","authenticated-orcid":false,"given":"Duvuru","family":"Geetha","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 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