{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:30:19Z","timestamp":1786480219661,"version":"build-2736575974"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"FEDER","doi-asserted-by":"crossref","award":["N\u00b02016-00110366=BIO- TARGET 2015-2018"],"award-info":[{"award-number":["N\u00b02016-00110366=BIO- TARGET 2015-2018"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"FEDER","doi-asserted-by":"crossref","award":["N\u00b0 EX005756 =BIO-TARGETII"],"award-info":[{"award-number":["N\u00b0 EX005756 =BIO-TARGETII"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>\n                            A knockout mouse targeting the molybdenum cofactor sulfurase (\n                            <jats:italic toggle=\"yes\">Mocos<\/jats:italic>\n                            ) gene develops xanthinuria type II with lethal obstructive nephropathy.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Xanthinuric\n                            <jats:italic toggle=\"yes\">Mocos<\/jats:italic>\n                            knockout mice display moderate renal inflammation and fibrosis, normocytic anemia, and reduced detoxification defense systems.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Purine, but also amino acid and phospholipid, metabolic pathways are altered in\n                            <jats:italic toggle=\"yes\">Mocos<\/jats:italic>\n                            knockout kidneys.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Xanthinuria type II is a rare autosomal purine disorder. This recessive defect of purine metabolism remains an under-recognized disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Mice with targeted disruption of the molybdenum cofactor sulfurase (\n                      <jats:italic toggle=\"yes\">Mocos<\/jats:italic>\n                      ) gene were generated to enable an integrated understanding of purine disorders and evaluate pathophysiologic functions of this gene which is found in a large number of pathways and is known to be associated with autism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Mocos<\/jats:italic>\n                      -deficient mice die with 4 weeks of age due to renal failure of distinct obstructive nephropathy with xanthinuria, xanthine deposits, cystic tubular dilation, Tamm\u2013Horsfall (uromodulin) protein (THP) deposits, tubular cell necrosis with neutrophils, and occasionally hydronephrosis with urolithiasis. Obstructive nephropathy is associated with moderate interstitial inflammatory and fibrotic responses, anemia, reduced detoxification systems, and important alterations of the metabolism of purines, amino acids, and phospholipids. Conversely, heterozygous mice expressing reduced MOCOS protein are healthy with no apparent pathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Mocos<\/jats:italic>\n                      -deficient mice develop a lethal obstructive nephropathy associated with profound metabolic changes. Studying MOCOS functions may provide important clues about the underlying pathogenesis of xanthinuria and other diseases requiring early diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0001732021","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T15:40:17Z","timestamp":1631893217000},"page":"1793-1806","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Deletion of Mocos Induces Xanthinuria with Obstructive Nephropathy and Major Metabolic Disorders in Mice"],"prefix":"10.34067","volume":"2","author":[{"given":"Delphine","family":"Sedda","sequence":"first","affiliation":[{"name":"Experimental and Molecular Immunology and Neurogenetics (INEM), Orl\u00e9ans University, Centre National de la Recherche Scientifique (CNRS) UMR7355, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1267-5905","authenticated-orcid":false,"given":"Claire","family":"Mackowiak","sequence":"additional","affiliation":[{"name":"Experimental and Molecular Immunology and Neurogenetics (INEM), Orl\u00e9ans University, Centre National de la Recherche Scientifique (CNRS) UMR7355, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Pailloux","sequence":"additional","affiliation":[{"name":"Experimental and Molecular Immunology and Neurogenetics (INEM), Orl\u00e9ans University, Centre National de la Recherche Scientifique (CNRS) UMR7355, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Culerier","sequence":"additional","affiliation":[{"name":"Experimental and Molecular Immunology and Neurogenetics (INEM), Orl\u00e9ans University, Centre National de la Recherche Scientifique (CNRS) UMR7355, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8189-3466","authenticated-orcid":false,"given":"Ana","family":"Dudas","sequence":"additional","affiliation":[{"name":"Experimental and Molecular Immunology and Neurogenetics (INEM), Orl\u00e9ans University, Centre National de la Recherche Scientifique (CNRS) UMR7355, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Rontani","sequence":"additional","affiliation":[{"name":"Institute of NeuroPhysiopathology (INP), Aix-Marseille University, CNRS UMR7051, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Erard","sequence":"additional","affiliation":[{"name":"Institute of NeuroPhysiopathology (INP), Aix-Marseille University, CNRS UMR7051, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Lefevre","sequence":"additional","affiliation":[{"name":"iBrain, Tours University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMR 1253, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1424-2698","authenticated-orcid":false,"given":"Sylvie","family":"Mavel","sequence":"additional","affiliation":[{"name":"iBrain, Tours University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMR 1253, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5324-2164","authenticated-orcid":false,"given":"Patrick","family":"Emond","sequence":"additional","affiliation":[{"name":"iBrain, Tours University, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) UMR 1253, Tours, France"},{"name":"Division of In Vitro Nuclear Medicine, Regional University Hospital of Tours, Tours, France"},{"name":"PST Analysis of Biological Systems, Tours University, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6037-8633","authenticated-orcid":false,"given":"Frederic","family":"Foucher","sequence":"additional","affiliation":[{"name":"Center for Molecular Biophysics (CBM), CNRS UPR4301, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5945-3800","authenticated-orcid":false,"given":"Marc","family":"Le Bert","sequence":"additional","affiliation":[{"name":"Experimental and Molecular Immunology and Neurogenetics (INEM), Orl\u00e9ans University, Centre National de la Recherche Scientifique (CNRS) UMR7355, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2907-7995","authenticated-orcid":false,"given":"Valerie F.J.","family":"Quesniaux","sequence":"additional","affiliation":[{"name":"Experimental and Molecular Immunology and Neurogenetics (INEM), Orl\u00e9ans University, Centre National de la Recherche Scientifique (CNRS) UMR7355, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Mihatsch","sequence":"additional","affiliation":[{"name":"Institute for Pathology, University Hospital of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Ryffel","sequence":"additional","affiliation":[{"name":"Experimental and Molecular Immunology and Neurogenetics (INEM), Orl\u00e9ans University, Centre National de la Recherche Scientifique (CNRS) UMR7355, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-706X","authenticated-orcid":false,"given":"Madeleine","family":"Erard-Garcia","sequence":"additional","affiliation":[{"name":"Experimental and Molecular Immunology and Neurogenetics (INEM), Orl\u00e9ans University, Centre National de la Recherche Scientifique (CNRS) UMR7355, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"B1-20250825","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/BF00866732","article-title":"Acute renal failure due to xanthine stones","volume":"9","author":"Bradbury","year":"1995","journal-title":"Pediatr Nephrol"},{"key":"B2-20250825","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/221170a0","article-title":"Crystalline deposits in striped muscle in xanthinuria","volume":"221","author":"Chalmers","year":"1969","journal-title":"Nature"},{"key":"B3-20250825","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1124\/pr.58.1.6","article-title":"Therapeutic effects of xanthine oxidase inhibitors: Renaissance half a century after the discovery of allopurinol","volume":"58","author":"Pacher","year":"2006","journal-title":"Pharmacol Rev"},{"key":"B4-20250825","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1006\/bbrc.2001.4719","article-title":"Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II","volume":"282","author":"Ichida","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"B5-20250825","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/S0026-0495(03)00272-5","article-title":"Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II","volume":"52","author":"Yamamoto","year":"2003","journal-title":"Metabolism"},{"key":"B6-20250825","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ymgme.2007.02.005","article-title":"Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria","volume":"91","author":"Peretz","year":"2007","journal-title":"Mol Genet Metab"},{"key":"B7-20250825","doi-asserted-by":"crossref","first-page":"21789","DOI":"10.1074\/jbc.C000230200","article-title":"Deletion mutation in Drosophila ma-l homologous, putative molybdopterin cofactor sulfurase gene is associated with bovine xanthinuria type II","volume":"275","author":"Watanabe","year":"2000","journal-title":"J Biol Chem"},{"key":"B8-20250825","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1159\/000374042","article-title":"Using next-generation sequencing to identify a mutation in human MCSU that is responsible for type II xanthinuria","volume":"35","author":"Zhou","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"B9-20250825","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12917-016-0904-4","article-title":"A frameshift mutation in MOCOS is associated with familial renal syndrome (xanthinuria) in Tyrolean Grey cattle","volume":"12","author":"Murgiano","year":"2016","journal-title":"BMC Vet Res"},{"key":"B10-20250825","doi-asserted-by":"crossref","first-page":"118883","DOI":"10.1016\/j.bbamcr.2020.118883","article-title":"Molybdenum cofactor biology, evolution and deficiency","volume":"1868","author":"Mayr","year":"2021","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"B11-20250825","first-page":"55","article-title":"MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases","volume":"207","author":"Anantharaman","year":"2002","journal-title":"FEMS Microbiol Lett"},{"key":"B12-20250825","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1021\/cr400443z","article-title":"The mononuclear molybdenum enzymes","volume":"114","author":"Hille","year":"2014","journal-title":"Chem Rev"},{"key":"B13-20250825","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fpls.2014.00028","article-title":"Molybdenum metabolism in plants and crosstalk to iron","volume":"5","author":"Bittner","year":"2014","journal-title":"Front Plant Sci"},{"key":"B14-20250825","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1016\/j.bbadis.2018.05.003","article-title":"The role of xanthine oxidoreductase and uric acid in metabolic syndrome","volume":"1864","author":"Battelli","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B15-20250825","doi-asserted-by":"crossref","first-page":"15475","DOI":"10.3390\/ijms131115475","article-title":"Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans","volume":"13","author":"Ichida","year":"2012","journal-title":"Int J Mol Sci"},{"key":"B16-20250825","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.1038\/ncomms7555","article-title":"Xanthine oxidoreductase regulates macrophage IL1\u03b2 secretion upon NLRP3 inflammasome activation","volume":"6","author":"Ives","year":"2015","journal-title":"Nat Commun"},{"key":"B17-20250825","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00204-016-1683-1","article-title":"Structure and function of mammalian aldehyde oxidases","volume":"90","author":"Terao","year":"2016","journal-title":"Arch Toxicol"},{"key":"B18-20250825","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1021\/bi3000879","article-title":"Aldehyde oxidase functions as a superoxide generating NADH oxidase: An important redox regulated pathway of cellular oxygen radical formation","volume":"51","author":"Kundu","year":"2012","journal-title":"Biochemistry"},{"key":"B19-20250825","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1074\/jbc.REV119.007741","article-title":"Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes","volume":"295","author":"Terao","year":"2020","journal-title":"J Biol Chem"},{"key":"B20-20250825","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/mp.2015.106","article-title":"Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders","volume":"21","author":"F\u00e9ron","year":"2016","journal-title":"Mol Psychiatry"},{"key":"B21-20250825","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s11011-019-00524-y","article-title":"The rs594445 in MOCOS gene is associated with risk of autism spectrum disorder","volume":"35","author":"Taheri","year":"2020","journal-title":"Metab Brain Dis"},{"key":"B22-20250825","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/s41380-020-0728-2","article-title":"Impaired expression of the COSMOC\/MOCOS gene unit in ASD patient stem cells","volume":"26","author":"Rontani","year":"2021","journal-title":"Mol Psychiatry"},{"key":"B23-20250825","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jpba.2017.03.068","article-title":"Workflow methodology for rat brain metabolome exploration using NMR, LC-MS and GC-MS analytical platforms","volume":"142","author":"Di\u00e9m\u00e9","year":"2017","journal-title":"J Pharm Biomed Anal"},{"key":"B24-20250825","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.talanta.2018.11.094","article-title":"Validation of a global quantitative analysis methodology of tryptophan metabolites in mice using LC-MS","volume":"195","author":"Lef\u00e8vre","year":"2019","journal-title":"Talanta"},{"key":"B25-20250825","doi-asserted-by":"crossref","first-page":"14.10.1","DOI":"10.1002\/cpbi.11","article-title":"Using metaboanalyst 3.0 for comprehensive metabolomics data analysis","volume":"55","author":"Xia","year":"2016","journal-title":"Curr Protoc Bioinformatics"},{"key":"B26-20250825","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1681\/ASN.2011111078","article-title":"Mechanisms of anemia in CKD","volume":"23","author":"Babitt","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"B27-20250825","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: The master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"B28-20250825","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of renal fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu Rev Physiol"},{"key":"B29-20250825","doi-asserted-by":"crossref","first-page":"2917474","DOI":"10.1155\/2020\/2917474","article-title":"PPAR\u03b3 and its agonists in chronic kidney disease","volume":"2020","author":"Ma","year":"2020","journal-title":"Int J Nephrol"},{"key":"B30-20250825","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1089\/ars.2016.6804","article-title":"The kidney: An organ in the front line of oxidative stress-associated pathologies","volume":"25","author":"Gorin","year":"2016","journal-title":"Antioxid Redox Signal"},{"key":"B31-20250825","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/s41374-018-0078-8","article-title":"Thioredoxin-interacting protein deficiency ameliorates kidney inflammation and fibrosis in mice with unilateral ureteral obstruction","volume":"98","author":"Wu","year":"2018","journal-title":"Lab Invest"},{"key":"B32-20250825","doi-asserted-by":"crossref","first-page":"16008","DOI":"10.1038\/nrdp.2016.8","article-title":"Kidney stones","volume":"2","author":"Khan","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"B33-20250825","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nrneph.2017.10","article-title":"Crystal nephropathies: Mechanisms of crystal-induced kidney injury","volume":"13","author":"Mulay","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"B34-20250825","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1172\/JCI63679","article-title":"Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1\u03b2 secretion","volume":"123","author":"Mualy","year":"2013","journal-title":"J Clin Invest"},{"key":"B35-20250825","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1097\/01.ASN.0000034910.58454.FD","article-title":"A role for uric acid in the progression of renal disease","volume":"13","author":"Kang","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"B36-20250825","doi-asserted-by":"crossref","first-page":"2180373","DOI":"10.1155\/2018\/2180373","article-title":"Inflammation-related mechanisms in chronic kidney disease prediction, progression, and outcome","volume":"2018","author":"Mihai","year":"2018","journal-title":"J Immunol Res"},{"key":"B37-20250825","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5414\/CN106949","article-title":"Hereditary renal hypouricemia: A cause of calcium oxalate urolithiasis in a young female","volume":"77","author":"Nishizaki","year":"2012","journal-title":"Clin Nephrol"},{"key":"B38-20250825","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.2337\/db06-0283","article-title":"Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers","volume":"55","author":"Waring","year":"2006","journal-title":"Diabetes"},{"key":"B39-20250825","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00345-015-1563-y","article-title":"Involvement of renin-angiotensin-aldosterone system in calcium oxalate crystal induced activation of NADPH oxidase and renal cell injury","volume":"34","author":"Tsuji","year":"2016","journal-title":"World J Urol"},{"key":"B40-20250825","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1046\/j.1523-1755.2000.07615.x","article-title":"Relevance of oxidative and carbonyl stress to long-term uremic complications","volume":"76","author":"Miyata","year":"2000","journal-title":"Kidney Int Suppl"},{"key":"B41-20250825","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/ars.2016.6665","article-title":"Oxidant mechanisms in renal injury and disease","volume":"25","author":"Ratliff","year":"2016","journal-title":"Antioxid Redox Signal"},{"key":"B42-20250825","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13229-016-0109-5","article-title":"Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism","volume":"7","author":"Gevi","year":"2016","journal-title":"Mol Autism"},{"key":"B43-20250825","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fncel.2019.00007","article-title":"Altered urinary amino acids in children with autism spectrum disorders","volume":"13","author":"Liu","year":"2019","journal-title":"Front Cell Neurosci"}],"container-title":["Kidney360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0001732021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:58:27Z","timestamp":1786478307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0001732021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.34067\/kid.0001732021","relation":{},"ISSN":["2641-7650"],"issn-type":[{"value":"2641-7650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"2021-03-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}