{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:31:45Z","timestamp":1786480305028,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","funder":[{"DOI":"10.13039\/100012007","name":"Rockefeller University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011207","name":"New York Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011207","id-type":"DOI","asserted-by":"publisher"}]},{"name":"N2: Building a Network of Safety-Net PBRNs","award":["AHRQ 1-P30-HS-021667"],"award-info":[{"award-number":["AHRQ 1-P30-HS-021667"]}]},{"DOI":"10.13039\/100006108","name":"The National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1TR001866"],"award-info":[{"award-number":["UL1TR001866"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"The National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1 TR000043"],"award-info":[{"award-number":["UL1 TR000043"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006093","name":"PCORI","doi-asserted-by":"publisher","award":["CDRN-1306-03961"],"award-info":[{"award-number":["CDRN-1306-03961"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Adolescent obesity, a risk factor for cardiorenal morbidity in adulthood, has reached epidemic proportions. Obesity-related glomerulopathy (ORG) has an early reversible stage of hyperfiltration. Age-appropriate formulae for eGFR, which are standardized to ideal body surface area (BSA) and provide assessment of kidney function in ml\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      , may underestimate prevalence of early ORG. We investigated whether adjusting eGFR to actual BSA more readily identifies early ORG.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We studied a cohort of 22,417 young individuals, aged 12\u201321 years, from a New York metropolitan multi-institutional electronic health records clinical database. eGFR was calculated in two ways: BSA-standardized eGFR, and absolute eGFR. Hyperfiltration was defined above a threshold of 135 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      or 135 ml\/min, respectively. The prevalence of hyperfiltration according to each formula was assessed in parallel to creatinine clearance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum creatinine values and hyperfiltration prevalence according to BSA-standardized eGFR were similar, 13%\u201315%, across body mass index (BMI) groups. The prevalence of hyperfiltration determined by absolute eGFR differed across BMI groups: underweight, 2%; normal weight, 6%; overweight, 17%; and obese, 31%. This trend paralleled the rise in creatinine clearance across BMI groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Absolute eGFR more readily identifies early ORG than the currently used formulae, which are adjusted to a standardized BSA and are not representative of current population BMI measures. Using absolute eGFR in clinical practice and research may improve the ability to identify, intervene, and reverse early ORG, which has great importance with increasing obesity rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0005312021","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T18:10:21Z","timestamp":1636654221000},"page":"113-121","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Obesity Related Glomerulopathy in Adolescent Women: The Effect of Body Surface Area"],"prefix":"10.34067","volume":"3","author":[{"given":"Dana","family":"Bielopolski","sequence":"first","affiliation":[{"name":"The Rockefeller University Center for Clinical and Translational Science, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Singh","sequence":"additional","affiliation":[{"name":"The Rockefeller University Center for Clinical and Translational Science, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohad S.","family":"Bentur","sequence":"additional","affiliation":[{"name":"The Rockefeller University Center for Clinical and Translational Science, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Renert-Yuval","sequence":"additional","affiliation":[{"name":"The Rockefeller University Center for Clinical and Translational Science, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"MacArthur","sequence":"additional","affiliation":[{"name":"The Rockefeller University Center for Clinical and Translational Science, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly S.","family":"Vasquez","sequence":"additional","affiliation":[{"name":"The Rockefeller University Center for Clinical and Translational Science, New York, New 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York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan N.","family":"Tobin","sequence":"additional","affiliation":[{"name":"The Rockefeller University Center for Clinical and Translational Science, New York, New York"},{"name":"Clinical Directors Network, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"B1-20250825","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s00467-012-2353-z","article-title":"Is obesity a risk factor for chronic kidney disease in children?","volume":"28","author":"Gunta","year":"2013","journal-title":"Pediatr Nephrol"},{"key":"B3-20250825","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/pr.2015.130","article-title":"Decreased renal function in overweight and obese prepubertal children","volume":"78","author":"Correia-Costa","year":"2015","journal-title":"Pediatr 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