{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:56:19Z","timestamp":1792806979374,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","funder":[{"name":"Cleveland Clinic Caregiver Catalyst Grant","award":["CCG 0093"],"award-info":[{"award-number":["CCG 0093"]}],"id":[{"id":"https:\/\/ror.org\/03xjacd83","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2022,12]]},"abstract":"\n Key Points<\/jats:title>\n \n \n \n Kidney biopsy registries in the United States are lacking.<\/jats:p>\n <\/jats:list-item>\n \n We provide a multicenter, multistate kidney biopsy database in the United States and identified demographic and clinical trends.<\/jats:p>\n <\/jats:list-item>\n \n Our study catalogs the spectrum of biopsy-proven kidney disease across the Cleveland Clinic enterprise andhighlights the need for a standardized national kidney biopsy registry to bolster glomerular and kidney disease research in the United States.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n The kidney biopsy is the gold standard for diagnosing glomerular diseases. Large-scale, epidemiologic studies describing the prevalence of kidney diseases are lacking, especially in the United States. We aimed to determine the spectrum of biopsy-proven kidney disease across the Cleveland Clinic enterprise.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We identified all patients with a native kidney biopsy performed or reviewed at the Cleveland Clinic from January 2015 to September 2021. Retrospective chart review was performed to obtain clinical and demographic characteristics. Results were stratified by age, sex, race, and location to determine epidemiologic trends.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of >9600 patients, we excluded transplant and donor biopsies and unavailable records, and included 4128 patients with native kidney biopsy data. The median age was 60 years, with 46% female patients. Self-reported racial demographics included 73% White, 22% Black, 3% multiracial, and 2% Asian background, with 5% Hispanic. Common diagnoses were: FSGS (\n n<\/jats:italic>\n =633, 15%), diabetic kidney disease (DKD) (\n n<\/jats:italic>\n =602, 15%), IgA nephropathy (\n n<\/jats:italic>\n =319, 8%), lupus nephritis (LN) (\n n<\/jats:italic>\n =289, 7%), pauci-immune glomerulonephritis (\n n<\/jats:italic>\n =275, 7%), membranous nephropathy (\n n<\/jats:italic>\n =211, 5%), and amyloidosis (\n n<\/jats:italic>\n =110, 3%). There were 3322 patients in Ohio, with 361 patients in Florida. Using multivariate analysis, those aged >70 years were more likely to have FSGS, whereas those <45 years were more likely to have IgA nephropathy or LN. Males were more likely to have FSGS or IgAN, and less likely to have LN. Black patients were more likely to have FSGS, DKD, or LN. Hispanic patients were more likely to have DKD. Finally, patients in Florida were more likely to have LN. There was no change in the disease spectrum before and during the COVID-19 pandemic.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our study catalogs the spectrum of biopsy-proven kidney disease across the Cleveland Clinic enterprise. This lays the foundation for glomerular disease clinical trials, and highlights the need for a standardized national kidney biopsy registry to bolster glomerular and kidney disease research in the United States.<\/jats:p>\n <\/jats:sec>","DOI":"10.34067\/kid.0005882022","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T08:55:14Z","timestamp":1666169714000},"page":"2077-2085","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["The Cleveland Clinic Kidney Biopsy Epidemiological Project"],"prefix":"10.34067","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6830-0948","authenticated-orcid":false,"given":"Shane A.","family":"Bobart","sequence":"first","affiliation":[{"name":"Department of Kidney Medicine, Cleveland Clinic Florida, Weston, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilda","family":"Portalatin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic Florida, Weston, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanny","family":"Sawaf","sequence":"additional","affiliation":[{"name":"Department of Kidney Medicine, Cleveland Clinic Ohio, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Shettigar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic Florida, Weston, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Carrion-Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic Florida, Weston, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9148-8894","authenticated-orcid":false,"given":"Hong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Cleveland Clinic Florida, Weston, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-8559","authenticated-orcid":false,"given":"Leal","family":"Herlitz","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Cleveland Clinic Ohio, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surafel K.","family":"Gebreselassie","sequence":"additional","affiliation":[{"name":"Department of Kidney Medicine, Cleveland Clinic Florida, Weston, 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