{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:04:25Z","timestamp":1787133865982,"version":"build-2736575974"},"reference-count":77,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","funder":[{"name":"University of Alabama at Birmingham (UAB) School of Medicine AMC21"},{"name":"Polycystic Kidney Disease Research Foundation","award":["214g16a"],"award-info":[{"award-number":["214g16a"]}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK115752"],"award-info":[{"award-number":["R01DK115752"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K01DK119375"],"award-info":[{"award-number":["K01DK119375"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Baltimore PKD Center","award":["2P30DK090868"],"award-info":[{"award-number":["2P30DK090868"]}]},{"name":"UAB Hepato\/Renal Fibrocystic Disease Core Center","award":["5P30DK074038"],"award-info":[{"award-number":["5P30DK074038"]}]},{"DOI":"10.13039\/100001298","name":"Presbyterian Health Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001298","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Oklahoma Center for Microbial Pathogenesis and Immunity","award":["1P20GM134973"],"award-info":[{"award-number":["1P20GM134973"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Interstitial inflammation is an important feature of cystic kidney disease. Renal macrophages are the most well-studied inflammatory cell in the kidney, and their involvement in cyst formation has been reported in different animal models and patients with cystic kidney disease. Originally, it was believed that renal macrophages were maintained from a constant supply of bone marrow\u2013derived circulating monocytes, and could be recruited to the kidney in response to local inflammation. However, this idea has been challenged using fate-mapping methods, by showing that at least two distinct developmental origins of macrophages are present in the adult mouse kidney. The first type, infiltrating macrophages, are recruited from circulating monocytes and gradually develop macrophage properties on entering the kidney. The second, resident macrophages, predominantly originate from embryonic precursors, colonize the kidney during its development, and proliferate\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    to maintain their population throughout adulthood. Infiltrating and resident macrophages work together to maintain homeostasis and properly respond to pathologic conditions, such as AKI, cystic kidney disease, or infection. This review will briefly summarize current knowledge of resident macrophages in cystic kidney disease.\n                  <\/jats:p>","DOI":"10.34067\/kid.0006052020","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T14:31:11Z","timestamp":1607697071000},"page":"167-175","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":20,"title":["Resident Macrophages in Cystic Kidney Disease"],"prefix":"10.34067","volume":"2","clinical-trial-number":[{"clinical-trial-number":"nct02115659","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Zhang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt A.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0247-1944","authenticated-orcid":false,"given":"Bradley K.","family":"Yoder","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"B1-20250825","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.semnephrol.2010.03.003","article-title":"Macrophages and immunologic inflammation of the kidney","volume":"30","author":"Duffield","year":"2010","journal-title":"Semin Nephrol"},{"key":"B2-20250825","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3389\/fphys.2019.01016","article-title":"The impact of versatile macrophage functions on acute kidney injury and its outcomes","volume":"10","author":"Baek","year":"2019","journal-title":"Front Physiol"},{"key":"B3-20250825","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.kint.2018.10.041","article-title":"M2 macrophages in kidney disease: Biology, therapies, and perspectives","volume":"95","author":"Chen","year":"2019","journal-title":"Kidney Int"},{"key":"B4-20250825","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fimmu.2014.00514","article-title":"From monocytes to M1\/M2 macrophages: Phenotypical vs. functional differentiation","volume":"5","author":"Italiani","year":"2014","journal-title":"Front Immunol"},{"key":"B5-20250825","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"B6-20250825","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.cell.2014.11.018","article-title":"Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment","volume":"159","author":"Lavin","year":"2014","journal-title":"Cell"},{"key":"B7-20250825","doi-asserted-by":"crossref","first-page":"F640","DOI":"10.1152\/ajprenal.00369.2016","article-title":"Mononuclear phagocyte subpopulations in the mouse kidney","volume":"312","author":"George","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"B8-20250825","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The dendritic cell lineage: Ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting","volume":"31","author":"Merad","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"B9-20250825","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1126\/science.1178331","article-title":"Development of monocytes, macrophages, and dendritic cells","volume":"327","author":"Geissmann","year":"2010","journal-title":"Science"},{"key":"B10-20250825","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1681\/ASN.2019040419","article-title":"The kidney contains ontogenetically distinct dendritic cell and macrophage subtypes throughout development that differ in their inflammatory properties","volume":"31","author":"Salei","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"B11-20250825","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1681\/ASN.2018090931","article-title":"Single-cell RNA sequencing identifies candidate renal resident macrophage gene expression signatures across species","volume":"30","author":"Zimmerman","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"B12-20250825","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.1219179","article-title":"A lineage of myeloid cells independent of Myb and hematopoietic stem cells","volume":"336","author":"Schulz","year":"2012","journal-title":"Science"},{"key":"B13-20250825","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.immuni.2015.03.011","article-title":"C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages","volume":"42","author":"Hoeffel","year":"2015","journal-title":"Immunity"},{"key":"B14-20250825","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3389\/fimmu.2015.00486","article-title":"Ontogeny of tissue-resident macrophages","volume":"6","author":"Hoeffel","year":"2015","journal-title":"Front Immunol"},{"key":"B15-20250825","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.bbadis.2013.02.016","article-title":"Bone marrow-derived cells play a major role in kidney fibrosis via proliferation and differentiation in the infiltrated site","volume":"1832","author":"Jang","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"B16-20250825","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.immuni.2015.07.016","article-title":"Most tissue-resident macrophages except microglia are derived from fetal hematopoietic stem cells","volume":"43","author":"Sheng","year":"2015","journal-title":"Immunity"},{"key":"B17-20250825","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3389\/fphys.2017.00837","article-title":"The origins and functions of tissue-resident macrophages in kidney development","volume":"8","author":"Munro","year":"2017","journal-title":"Front Physiol"},{"key":"B18-20250825","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1038\/s41467-020-16158-z","article-title":"Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins","volume":"11","author":"Liu","year":"2020","journal-title":"Nat Commun"},{"key":"B19-20250825","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.cell.2019.08.009","article-title":"Fate mapping via ms4a3-expression history traces monocyte-derived cells","volume":"178","author":"Liu","year":"2019","journal-title":"Cell"},{"key":"B20-20250825","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1681\/ASN.2018080810","article-title":"Tissue-resident macrophages promote renal cystic disease","volume":"30","author":"Zimmerman","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"B21-20250825","doi-asserted-by":"crossref","first-page":"e125503","DOI":"10.1172\/jci.insight.125503","article-title":"Resident macrophages reprogram toward a developmental state after acute kidney injury","volume":"4","author":"Lever","year":"2019","journal-title":"JCI Insight"},{"key":"B22-20250825","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.cell.2016.06.058","article-title":"Immune monitoring of trans-endothelial transport by kidney-resident macrophages","volume":"166","author":"Stamatiades","year":"2016","journal-title":"Cell"},{"key":"B23-20250825","doi-asserted-by":"crossref","first-page":"e43271","DOI":"10.7554\/eLife.43271","article-title":"Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development","volume":"8","author":"Munro","year":"2019","journal-title":"eLife"},{"key":"B24-20250825","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.cell.2019.02.028","article-title":"Resident macrophages cloak tissue microlesions to prevent neutrophil-driven inflammatory damage","volume":"177","author":"Uderhardt","year":"2019","journal-title":"Cell"},{"key":"B25-20250825","doi-asserted-by":"crossref","first-page":"816460","DOI":"10.1155\/2015\/816460","article-title":"Understanding the mysterious M2 macrophage through activation markers and effector mechanisms","volume":"2015","author":"R\u0151szer","year":"2015","journal-title":"Mediators Inflamm"},{"key":"B26-20250825","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1681\/ASN.2018010074","article-title":"Interactions between macrophages and cyst-lining epithelial cells promote kidney cyst growth in Pkd1-deficient mice","volume":"29","author":"Yang","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"B27-20250825","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1073\/pnas.0912228107","article-title":"Macrophage Wnt7b is critical for kidney repair and regeneration","volume":"107","author":"Lin","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B28-20250825","first-page":"183","article-title":"Macrophages in kidney injury, inflammation, and fibrosis","volume":"30","author":"Cao","year":"2015","journal-title":"Physiology (Bethesda)"},{"key":"B29-20250825","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/ki.2012.207","article-title":"Macrophage\/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia\/reperfusion injury in mice","volume":"82","author":"Ferenbach","year":"2012","journal-title":"Kidney Int"},{"key":"B30-20250825","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/ki.1993.79","article-title":"Autosomal-dominant polycystic kidney disease in the rat","volume":"43","author":"Cowley","year":"1993","journal-title":"Kidney Int"},{"key":"B31-20250825","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1681\/ASN.V10122534","article-title":"Clinical and pathologic findings in two new allelic murine models of polycystic kidney disease","volume":"10","author":"Vogler","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"B32-20250825","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1046\/j.1523-1755.2001.00065.x","article-title":"Increased renal expression of monocyte chemoattractant protein-1 and osteopontin in ADPKD in rats","volume":"60","author":"Cowley","year":"2001","journal-title":"Kidney Int"},{"key":"B33-20250825","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000101828","article-title":"Temporal relationship between renal cyst development, hypertension and cardiac hypertrophy in a new rat model of autosomal recessive polycystic kidney disease","volume":"30","author":"Phillips","year":"2007","journal-title":"Kidney Blood Press Res"},{"key":"B34-20250825","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1681\/ASN.2011010084","article-title":"Macrophages promote cyst growth in polycystic kidney disease","volume":"22","author":"Karihaloo","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"B35-20250825","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/ki.2012.446","article-title":"Macrophages promote polycystic kidney disease progression","volume":"83","author":"Swenson-Fields","year":"2013","journal-title":"Kidney Int"},{"key":"B36-20250825","doi-asserted-by":"crossref","first-page":"e98615","DOI":"10.15252\/embj.201798615","article-title":"Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney","volume":"37","author":"Viau","year":"2018","journal-title":"EMBO J"},{"key":"B37-20250825","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1681\/ASN.2018050518","article-title":"Mcp1 promotes macrophage-dependent cyst expansion in autosomal dominant polycystic kidney disease","volume":"29","author":"Cassini","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"B38-20250825","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1172\/JCI80467","article-title":"Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease","volume":"125","author":"Chen","year":"2015","journal-title":"J Clin Invest"},{"key":"B39-20250825","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.krcp.2012.07.002","article-title":"Mammalian target of rapamycin inhibition in polycystic kidney disease: From bench to bedside","volume":"31","author":"Kim","year":"2012","journal-title":"Kidney Res Clin Pract"},{"key":"B40-20250825","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.semnephrol.2008.03.003","article-title":"Vasopressin antagonists in polycystic kidney disease","volume":"28","author":"Torres","year":"2008","journal-title":"Semin Nephrol"},{"key":"B41-20250825","doi-asserted-by":"crossref","first-page":"G677","DOI":"10.1152\/ajpgi.00381.2017","article-title":"Primary cilia disruption differentially affects the infiltrating and resident macrophage compartment in the liver","volume":"314","author":"Zimmerman","year":"2018","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B42-20250825","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000369149","article-title":"Effects of MCP-1 inhibition by bindarit therapy in a rat model of polycystic kidney disease","volume":"129","author":"Zoja","year":"2015","journal-title":"Nephron"},{"key":"B43-20250825","doi-asserted-by":"crossref","first-page":"F343","DOI":"10.1152\/ajprenal.00240.2018","article-title":"MCP-1 promotes detrimental cardiac physiology, pulmonary edema, and death in the cpk model of polycystic kidney disease","volume":"317","author":"Salah","year":"2019","journal-title":"Am J Physiol Renal Physiol"},{"key":"B45-20250825","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/nep.12045","article-title":"Role of interstitial inflammation in the pathogenesis of polycystic kidney disease","volume":"18","author":"Ta","year":"2013","journal-title":"Nephrology (Carlton)"},{"key":"B46-20250825","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/978-3-319-51436-9_12","article-title":"Inflammation and fibrosis in polycystic kidney disease","volume":"60","author":"Song","year":"2017","journal-title":"Results Probl Cell Differ"},{"key":"B47-20250825","doi-asserted-by":"crossref","first-page":"109647","DOI":"10.1016\/j.cellsig.2020.109647","article-title":"Role of chemokines, innate and adaptive immunity","volume":"73","author":"Zimmerman","year":"2020","journal-title":"Cell Signal"},{"key":"B48-20250825","doi-asserted-by":"crossref","first-page":"e133785","DOI":"10.1172\/jci.insight.133785","article-title":"Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression","volume":"5","author":"Lakhia","year":"2020","journal-title":"JCI Insight"},{"key":"B49-20250825","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.aat5031","article-title":"Spatiotemporal immune zonation of the human kidney","volume":"365","author":"Stewart","year":"2019","journal-title":"Science"},{"key":"B50-20250825","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/sj.ki.5002627","article-title":"Overexpression of innate immune response genes in a model of recessive polycystic kidney disease","volume":"73","author":"Mrug","year":"2008","journal-title":"Kidney Int"},{"key":"B51-20250825","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1681\/ASN.2012020154","article-title":"Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption","volume":"24","author":"Sharma","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"B52-20250825","doi-asserted-by":"crossref","first-page":"16078","DOI":"10.1073\/pnas.0502000102","article-title":"Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580","volume":"102","author":"Conway","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B53-20250825","doi-asserted-by":"crossref","first-page":"179","DOI":"10.34067\/KID.0001052019","article-title":"Interferon regulatory factor\u20105 in resident macrophage promotes polycystic kidney disease","volume":"1","author":"Zimmerman","year":"2020","journal-title":"Kidney360"},{"key":"B54-20250825","doi-asserted-by":"crossref","first-page":"245804","DOI":"10.1155\/2013\/245804","article-title":"IRF5 is a specific marker of inflammatory macrophages in vivo","volume":"2013","author":"Weiss","year":"2013","journal-title":"Mediators Inflamm"},{"key":"B55-20250825","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1172\/JCI72272","article-title":"Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease","volume":"124","author":"Harris","year":"2014","journal-title":"J Clin Invest"},{"key":"B56-20250825","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/labinvest.2015.153","article-title":"Wnt\/\u03b2-catenin signaling in kidney injury and repair: A double-edged sword","volume":"96","author":"Zhou","year":"2016","journal-title":"Lab Invest"},{"key":"B57-20250825","doi-asserted-by":"crossref","first-page":"a008078","DOI":"10.1101\/cshperspect.a008078","article-title":"Wnt signaling and injury repair","volume":"4","author":"Whyte","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B58-20250825","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1681\/ASN.2014121188","article-title":"Paracrine Wnt1 drives interstitial fibrosis without inflammation by tubulointerstitial cross-talk","volume":"27","author":"Maarouf","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B59-20250825","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2353\/ajpath.2009.090227","article-title":"Pkd2 dosage influences cellular repair responses following ischemia-reperfusion injury","volume":"175","author":"Prasad","year":"2009","journal-title":"Am J Pathol"},{"key":"B60-20250825","doi-asserted-by":"crossref","first-page":"830","DOI":"10.2353\/ajpath.2007.060455","article-title":"Involvement of hypoxia-inducible transcription factors in polycystic kidney disease","volume":"170","author":"Bernhardt","year":"2007","journal-title":"Am J Pathol"},{"key":"B61-20250825","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.kint.2018.06.025","article-title":"CD8+ T cells modulate autosomal dominant polycystic kidney disease progression","volume":"94","author":"Kleczko","year":"2018","journal-title":"Kidney Int"},{"key":"B62-20250825","doi-asserted-by":"crossref","first-page":"e13951","DOI":"10.14814\/phy2.13951","article-title":"Urinary T cells correlate with rate of renal function loss in autosomal dominant polycystic kidney disease","volume":"7","author":"Zimmerman","year":"2019","journal-title":"Physiol Rep"},{"key":"B63-20250825","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/cmi.12580","article-title":"Macrophages: Sentinels and regulators of the immune system","volume":"18","author":"Franken","year":"2016","journal-title":"Cell Microbiol"},{"key":"B65-20250825","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.immuni.2017.10.006","article-title":"Tissue-resident macrophages are locally programmed for silent clearance of apoptotic cells","volume":"47","author":"Roberts","year":"2017","journal-title":"Immunity"},{"key":"B66-20250825","doi-asserted-by":"crossref","first-page":"13948","DOI":"10.1038\/s41598-018-31887-4","article-title":"Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney","volume":"8","author":"Puranik","year":"2018","journal-title":"Sci Rep"},{"key":"B67-20250825","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1681\/ASN.2014020195","article-title":"Vascular-resident CD169-positive monocytes and macrophages control neutrophil accumulation in the kidney with ischemia-reperfusion injury","volume":"26","author":"Karasawa","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"B68-20250825","doi-asserted-by":"crossref","first-page":"F141","DOI":"10.1152\/ajprenal.00465.2016","article-title":"Inflammatory cytokines regulate renal sodium transporters: How, where, and why?","volume":"313","author":"Norlander","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"B69-20250825","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.cmet.2015.11.013","article-title":"Interleukin-1 receptor activation potentiates salt reabsorption in angiotensin II-induced hypertension via the NKCC2 Co-transporter in the nephron","volume":"23","author":"Zhang","year":"2016","journal-title":"Cell Metab"},{"key":"B70-20250825","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1091\/mbc.e12-06-0424","article-title":"Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia","volume":"23","author":"Veit","year":"2012","journal-title":"Mol Biol Cell"},{"key":"B71-20250825","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1172\/JCI83931","article-title":"Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection","volume":"126","author":"Peteranderl","year":"2016","journal-title":"J Clin Invest"},{"key":"B72-20250825","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1681\/ASN.2014090856","article-title":"Vascular endothelial growth factor C for polycystic kidney diseases","volume":"27","author":"Huang","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"B73-20250825","doi-asserted-by":"crossref","first-page":"e48183","DOI":"10.7554\/eLife.48183","article-title":"Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease","volume":"8","author":"Jafree","year":"2019","journal-title":"eLife"},{"key":"B74-20250825","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1093\/hmg\/ddr338","article-title":"Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways","volume":"20","author":"Takakura","year":"2011","journal-title":"Hum Mol Genet"},{"key":"B75-20250825","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.chembiol.2005.09.009","article-title":"Studies on calcium dependence reveal multiple modes of action for triptolide","volume":"12","author":"Leuenroth","year":"2005","journal-title":"Chem Biol"},{"key":"B76-20250825","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1681\/ASN.2008030259","article-title":"Triptolide reduces cystogenesis in a model of ADPKD","volume":"19","author":"Leuenroth","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"B77-20250825","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.3390\/ijms19071953","article-title":"Targeting macrophages as a potential therapeutic intervention: Impact on inflammatory diseases and cancer","volume":"19","author":"Ponzoni","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B78-20250825","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"key":"B79-20250825","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.cell.2017.03.050","article-title":"Macrophages facilitate electrical conduction in the heart","volume":"169","author":"Hulsmans","year":"2017","journal-title":"Cell"}],"container-title":["Kidney360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0006052020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:02:08Z","timestamp":1786478528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0006052020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.34067\/kid.0006052020","relation":{},"ISSN":["2641-7650"],"issn-type":[{"value":"2641-7650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-10-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}