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Ceramide is a vital intermediate of sphingolipid metabolism, synthesized by\n                    <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                    and salvage pathways, producing multiple types of sphingolipids and their metabolites. Although mutations in gene-encoding enzymes regulating sphingolipid synthesis and metabolism cause distinct diseases, an abnormal sphingolipid metabolism contributes to various pathologic conditions, including kidney diseases. Excessive accumulation of glycosphingolipids and promotion of the ceramide salvage and sphingosine-1-phosphate (S1P) pathways are found in the damaged kidney. Acceleration of the sphingosine kinase\/S1P\/S1P receptor (SphK\/S1P\/S1PR) axis plays a central role in deteriorating kidney functions. The SphK\/S1P\/S1PR signaling impairment is also found during pregnancy complications, such as preeclampsia and intrauterine growth restriction (IUGR). This mini-review discusses the current state of knowledge regarding the role of sphingolipid metabolism on kidney diseases, and the possible involvement of preeclampsia and IUGR conditions.\n                  <\/jats:p>","DOI":"10.34067\/kid.0006322020","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T16:00:38Z","timestamp":1610035238000},"page":"534-541","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Sphingolipids and Kidney Disease: Possible Role of Preeclampsia and Intrauterine Growth Restriction (IUGR)"],"prefix":"10.34067","volume":"2","author":[{"given":"Rodrigo","family":"Yokota","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bhunu","sequence":"additional","affiliation":[{"name":"Department of 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