{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:13:48Z","timestamp":1790540028858,"version":"4.1.0"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2022,3,31]]},"abstract":"<jats:p>\n                    The role of aldosterone in regulating K\n                    <jats:sup>+<\/jats:sup>\n                    excretion in the distal nephron is well established in kidney physiology. In addition to effects on the kidney, aldosterone modulates K\n                    <jats:sup>+<\/jats:sup>\n                    and Na\n                    <jats:sup>+<\/jats:sup>\n                    transport in salivary fluid, sweat, airway epithelia, and colonic fluid. More controversial and less well defined is the role of aldosterone in determining the internal distribution of K\n                    <jats:sup>+<\/jats:sup>\n                    across cell membranes in nontransporting epithelia.\n                    <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                    studies have been limited by the difficulty in accurately measuring overall K\n                    <jats:sup>+<\/jats:sup>\n                    balance and factoring in both variability and secondary changes in acid-base balance, systemic hemodynamics, and other K\n                    <jats:sup>+<\/jats:sup>\n                    -regulatory factors such as hormones and adrenergic activity. Despite these limitations, the aggregate data support a contributory role of aldosterone along with insulin and catecholamines in the normal physiologic regulation of internal K\n                    <jats:sup>+<\/jats:sup>\n                    distribution. The authors speculate differences in tissue sensitivity to aldosterone may also contribute to differential tissue response of cardiac and skeletal muscle to conditions of total body K\n                    <jats:sup>+<\/jats:sup>\n                    depletion.\n                  <\/jats:p>","DOI":"10.34067\/kid.0006762021","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T17:50:14Z","timestamp":1642182614000},"page":"561-568","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":42,"title":["Extrarenal Effects of Aldosterone on Potassium Homeostasis"],"prefix":"10.34067","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7322-4692","authenticated-orcid":false,"given":"Biff F.","family":"Palmer","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Clegg","sequence":"additional","affiliation":[{"name":"Texas Tech Health Sciences Center, El Paso, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"B1-20250825","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.mayocp.2019.05.019","article-title":"Potassium binders for hyperkalemia in chronic kidney disease-diet, renin-angiotensin-aldosterone system inhibitor therapy, and hemodialysis","volume":"95","author":"Palmer","year":"2020","journal-title":"Mayo Clin Proc"},{"key":"B2-20250825","first-page":"F257","article-title":"Extrarenal potassium homeostasis","volume":"240","author":"Bia","year":"1981","journal-title":"Am J Physiol"},{"key":"B3-20250825","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/ki.1986.160","article-title":"Extrarenal potassium homeostasis","volume":"30","author":"Brown","year":"1986","journal-title":"Kidney Int"},{"key":"B4-20250825","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.2215\/CJN.04540511","article-title":"A critically swift response: Insulin-stimulated potassium and glucose transport in skeletal muscle","volume":"6","author":"Ho","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"B5-20250825","doi-asserted-by":"crossref","first-page":"C541","DOI":"10.1152\/ajpcell.2000.279.3.C541","article-title":"Mechanisms of sodium pump regulation","volume":"279","author":"Therien","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"B6-20250825","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.2215\/CJN.00750111","article-title":"Comparison of insulin action on glucose versus potassium uptake in humans","volume":"6","author":"Nguyen","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"B7-20250825","first-page":"809","article-title":"Evidence for a role of endogenous insulin and glucagon in the regulation of potassium homeostasis","volume":"81","author":"Santeusanio","year":"1973","journal-title":"J Lab Clin Med"},{"key":"B8-20250825","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0026-0495(74)90102-4","article-title":"Necessity for insulin in transfer of excess infused K to intracellular fluid","volume":"23","author":"Hiatt","year":"1974","journal-title":"Metabolism"},{"key":"B9-20250825","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1172\/JCI108958","article-title":"Influence of basal insulin and glucagon secretion on potassium and sodium metabolism. 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