{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:48:37Z","timestamp":1775918917634,"version":"3.50.1"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2023,3,23]]},"abstract":"<jats:p>Post-procedural bleeding is the main complication of percutaneous kidney biopsy (PKB). Therefore, aspirin is routinely withheld in patients undergoing PKB to reduce the bleeding risk. The authors aimed to examine the association between aspirin use and bleeding during PKB. This systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The article search was performed on the MEDLINE and SCOPUS using queries specific to each database. Article inclusion was limited to primary studies. The meta-analysis compared the risk of major bleeding events between the aspirin-exposed <jats:italic toggle=\"yes\">versus<\/jats:italic> nonexposed group. Pooled effect estimate was examined using random-effects presented as odds ratio (OR) with 95% confidence intervals (CI). Heterogeneity was assessed through Cochrane I<jats:sup>2<\/jats:sup> test statistics. Sensitivity and subgroup analyses were also performed according to kidney type. Ten studies were included in the review and four studies were included in the meta-analysis, reviewing a total of 34067 PKB. Definitions for significant aspirin exposure were inconsistent between studies, limiting comparisons. Studies with broader definitions for aspirin exposure mostly showed no correlation between aspirin use and post-biopsy bleeding. Studies with strict definitions for aspirin exposure found an increased risk for haemorrhagic events in the aspirin-exposed group. No significant differences were found between aspirin-exposed and the comparison group regarding major bleeding events [OR 1.72; 95% CI 0.50\u20135.89, I<jats:sup>2<\/jats:sup> = 84%]. High-quality evidence on the effect of aspirin on the bleeding risk is limited. Our meta-analysis did not show a significantly increased risk for major bleeding complications in aspirin-exposed patients. Further studies are needed to define a more comprehensive approach for clinical practice.<\/jats:p>","DOI":"10.34067\/kid.0000000000000091","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T13:00:34Z","timestamp":1679576434000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Effects of aspirin on kidney biopsy bleeding complications \u2013 a systematic review and meta-analysis (PROSPERO 2021 CRD42021261005)"],"prefix":"10.34067","author":[{"given":"Miguel","family":"Relvas","sequence":"first","affiliation":[{"name":"Nephrology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal."}]},{"given":"Joana","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Portugal."}]},{"given":"In\u00eas","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Portugal."}]},{"given":"Hugo","family":"Diniz","sequence":"additional","affiliation":[{"name":"Nephrology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal."}]},{"given":"Lu\u00eds","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Nephrology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal."},{"name":"UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal"}]},{"given":"Lu\u00eds","family":"Coentr\u00e3o","sequence":"additional","affiliation":[{"name":"Nephrology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal."},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Portugal."},{"name":"Nephrology & Infectious Diseases R&D, i3S - Institute for Research & Innovation in Health, Porto, Portugal."}]}],"member":"276","reference":[{"issue":"2","key":"B1-20240826","doi-asserted-by":"crossref","first-page":"354","DOI":"10.2215\/CJN.05750515","article-title":"The native kidney biopsy: update and evidence for best practice","volume":"11","author":"Hogan","year":"2016","journal-title":"Clin J Am Soc Nephrol."},{"issue":"12","key":"B2-20240826","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/j.1365-2362.2007.01885.x","article-title":"Risk management of renal biopsy: 1387 cases over 30 years in a single centre","volume":"37","author":"Stratta","year":"2007","journal-title":"Eur J Clin Invest."},{"issue":"3","key":"B3-20240826","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4103\/0971-4065.147374","article-title":"Percutaneous native kidney biopsy in patients receiving antiplatelet agents\u2014is it necessary to stop them 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(Lond)."},{"issue":"9","key":"B39-20240826","first-page":"698","article-title":"Using the automated biopsy gun with real-time ultrasound for native renal biopsy","volume":"4","author":"Ori","year":"2002","journal-title":"Isr Med Assoc J."},{"issue":"3","key":"B40-20240826","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/ndt\/gfac177","article-title":"The risks associated with percutaneous native kidney biopsies: a prospective study","volume":"38","author":"Andrulli","year":"2022","journal-title":"Nephrol Dial Transplant."},{"issue":"5","key":"B41-20240826","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2796.2005.01477.x","article-title":"Low-dose aspirin for secondary cardiovascular prevention\u2014cardiovascular risks after its perioperative withdrawal versus bleeding risks with its continuation\u2014review and meta-analysis","volume":"257","author":"Burger","year":"2005","journal-title":"J Intern 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