{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T17:04:18Z","timestamp":1765213458408,"version":"3.46.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There is sparse data about the change in HRQoL with the temporal progression of CKD. In this study, we assessed the association between change in CKD stages, overall and domain-specific QoL and determined the factors that were associated with this change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data was sourced from a multi-centre study that included 1,290 adult patients aged 18 years and over across 6 centres in Australia. EQ-5D-3L was collected at baseline, 2 and 4 years. Changes in CKD stages were treated as a time-varying exposure; generalized estimating equations were used to model the changes in HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>With reference to patients with CKD (G3-5), patients treated with dialysis had a reduction of 0.06 (-0.09 to -0.04) in overall HRQoL scores over the 4-years and experienced higher odds of reporting lower HRQoL across all domains: mobility (1.91 [1.53 \u2013 2.38]), self-care (2.30 [1.67 \u2013 3.16]), usual activity (2.70 [ 2.18 \u2013 3.38]), pain (1.19 [ 0.97 \u2013 1.46]) and anxiety (1.40 [1.12 \u2013 1.75]). Transplant recipients showed no significant decline in overall HRQoL (p = 0.13) but had increased odds of reduced mobility (1.74 [ 1.40 \u2013 2.18]) and usual activity (1.35 [1.07 \u2013 1.71]). Female sex, smoking, prevalent diabetes mellitus, lower educational attainment and Middle Eastern ethnicity were associated with lower HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients on maintenance dialysis, but not transplant recipients, experienced a significant decline in overall HRQoL (0.06) over the 4 years compared to patients with CKD (G3-5). These utility-based HRQOL estimates are essential for future economic evaluations in kidney trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0000001009","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T17:00:40Z","timestamp":1765213240000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Assessment of Health-Related Quality of Life in Adult with CKD"],"prefix":"10.34067","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9414-675X","authenticated-orcid":false,"given":"Owen","family":"Ng","sequence":"first","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children\u2019s Hospital at Westmead, NSW, Australia 2145"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-2516","authenticated-orcid":false,"given":"Armando","family":"Teixeira-Pinto","sequence":"additional","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children\u2019s Hospital at Westmead, NSW, Australia 2145"},{"name":"Sydney School of Public Health, University of Sydney, NSW, Australia, 2006"}]},{"given":"Anh","family":"Kieu","sequence":"additional","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children\u2019s Hospital at Westmead, NSW, Australia 2145"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-5825","authenticated-orcid":false,"given":"Anita","family":"van Zwieten","sequence":"additional","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children\u2019s Hospital at Westmead, NSW, Australia 2145"},{"name":"Sydney School of Public Health, University of Sydney, NSW, Australia, 2006"}]},{"given":"Anoushka","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children\u2019s Hospital at Westmead, NSW, Australia 2145"},{"name":"Leeder Centre for Health Policy, Economics and Data, Sydney School of Public Health, University of Sydney, NSW, Australia, 2006"}]},{"given":"Kirsten","family":"Howard","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, University of Sydney, NSW, Australia, 2006"},{"name":"Leeder Centre for Health Policy, Economics and Data, Sydney School of Public Health, University of Sydney, NSW, Australia, 2006"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-3572","authenticated-orcid":false,"given":"Wai H.","family":"Lim","sequence":"additional","affiliation":[{"name":"School of Medical and Health Science, Edith Cowan University, Western Australia, Australia"}]},{"given":"Jeremy R.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Renal and Transplant Medicine, Westmead Hospital, NSW, Australia, 2145"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8299-2650","authenticated-orcid":false,"given":"Simon D.","family":"Roger","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Gosford Hospital, Gosford, Australia"}]},{"given":"Michael J.","family":"Bourke","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Westmead Hospital, Westmead, University of Sydney, Australia"}]},{"given":"Shaundeep","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Concord Repatriation General Hospital, Concord, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0527-898X","authenticated-orcid":false,"given":"Steven J.","family":"Chadban","sequence":"additional","affiliation":[{"name":"Dpartment of Renal Medicine, Royal Prince Alfred Hospital, and Charles Perkins Centre, University of Sydney, NSW, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-6495","authenticated-orcid":false,"given":"Carol A.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northern Clinical School, Kolling Institute of Medical Research, NSW, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8973-9538","authenticated-orcid":false,"given":"Allison","family":"Jaure","sequence":"additional","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children\u2019s Hospital at Westmead, NSW, Australia 2145"},{"name":"Sydney School of Public Health, University of Sydney, NSW, Australia, 2006"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2548-4035","authenticated-orcid":false,"given":"Jonathan C.","family":"Craig","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5271-2603","authenticated-orcid":false,"given":"Jean","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, University of Sydney"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-7269","authenticated-orcid":false,"given":"Germaine","family":"Wong","sequence":"additional","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children\u2019s Hospital at Westmead, NSW, Australia 2145"},{"name":"Sydney School of Public Health, University of Sydney, NSW, Australia, 2006"},{"name":"Department of Renal and Transplant Medicine, Westmead Hospital, NSW, Australia, 2145"}]}],"member":"276","published-online":{"date-parts":[[2025,12,8]]},"container-title":["Kidney360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.34067\/KID.0000001009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T17:00:40Z","timestamp":1765213240000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.34067\/KID.0000001009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.34067\/kid.0000001009","relation":{},"ISSN":["2641-7650"],"issn-type":[{"value":"2641-7650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"2025-05-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}