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(2008): Molecular and cellular basis of microvascular perfusion deficits induced by <i>Clostridium perfringens<\/i> and <i>Clostridium septicum<\/i>. PLoS Pathog. <b>4<\/b>, e1000045.","DOI":"10.1371\/journal.ppat.1000045"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10)\u3000Honda, S., Sato, K., Totsuka, N., Fujiyama, S., Fujimoto, M., Miyake, K., Nakahashi-Oda, C., Tahara-Hanaoka, S., Shibuya, K., Shibuya, A. (2016): Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fc\u03b1\/\u03bcR-coupled TLR4 signalling. Nat. Commun. <b>7<\/b>, 11498.","DOI":"10.1038\/ncomms11498"},{"key":"11","unstructured":"11)\u3000Lacombe, C., Mayeux, P. (1998): Biology of erythropoietin. Haematologica <b>83<\/b>, 724\u2013732."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12)\u3000Lieschke, G.J., Grail, D., Hodgson, G., Metcalf, D., Stanley, E., Cheers, C., Fowler, K.J., Basu, S., Zhan, Y.F., Dunn, A.R. 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