{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:47:52Z","timestamp":1782604072796,"version":"3.54.5"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>\n          Aim: To investigate the efficacy of PET\/CT with 11C-methionine for localizing parathyroid adenomas in patients with suspected primary hyperparathyroidism and inconclusive results of cervical ultrasonography and 99mTc-MIBI-SPECT\/CT. Patients, method: Retrospective analysis of imaging data of 18 patients and correlation with clinical outcome, in particular intraoperative findings and histopathology of excised tissue. Results: 12 of 18 patients received surgery. In 10 patients single parathyroid adenomas were found (diameter: 5\u201320 mm), 2 patients presented parathyroid hyperplasia (5 excised hyperplastic glands (diameter: 2\u201312 mm). PET\/ CT correctly localized all adenomas and 1 of 5 hyperplastic glands. The sensitivity per patient was 91.7% (11 of 12), the sensitivity per lesion 73.3% (11 of 15). All lesions missed by PET\/CT had a size smaller than 9 mm and a volume of less than 0.2 ml. In 6 patients no surgery was performed. Five of them had a negative or atypical PET\/CT. Further follow-up indicated familial hypocalciuric hypercalcemia in 3 of them (thus, PET\/CT true negative), in the remaining 2 patients no validation is available. One patient with 2 highly suggestive lesions rejected surgery so far. Conclusion: PET\/CT with 11C-methionine is a very sensitive method for the detection of parathyroid adenomas, even if they are too small to be visualized by 99mTc-MIBI-SPECT\/CT.<\/jats:p>","DOI":"10.3413\/nukmed-0686-14-07","type":"journal-article","created":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T09:07:03Z","timestamp":1417079223000},"page":"26-30","source":"Crossref","is-referenced-by-count":17,"title":["11C-methionine PET\/CT after in conclusive 99mTc-MIBI-SPECT\/CT for localisation of parathyroid adenomas in primary hyperparathyroidism"],"prefix":"10.3413","volume":"54","author":[{"given":"U.","family":"Braeuning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Pfannenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gallwitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Teichmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mueller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Dittmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Reimold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2017,12,26]]},"reference":[{"key":"10.3413\/Nukmed-0686-14-07-1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.4459"},{"key":"10.3413\/Nukmed-0686-14-07-2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9746-4"},{"key":"10.3413\/Nukmed-0686-14-07-3","first-page":"974","volume":"116","author":"Hellman","year":"1994","journal-title":"Surgery"},{"key":"10.3413\/Nukmed-0686-14-07-4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3168"},{"key":"10.3413\/Nukmed-0686-14-07-5","first-page":"1443","volume":"44","author":"Mariani","year":"2003","journal-title":"J Nucl Med"},{"key":"10.3413\/Nukmed-0686-14-07-6","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-004-1610-1"},{"key":"10.3413\/Nukmed-0686-14-07-7","doi-asserted-by":"publisher","DOI":"10.4103\/2156-7514.102053"},{"key":"10.3413\/Nukmed-0686-14-07-8","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-0008-z"},{"key":"10.3413\/Nukmed-0686-14-07-9","first-page":"24","volume":"34","author":"Sandrock","year":"1993","journal-title":"J Nucl Med"},{"key":"10.3413\/Nukmed-0686-14-07-10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61213-6"},{"key":"10.3413\/Nukmed-0686-14-07-11","first-page":"1766","volume":"37","author":"Sundin","year":"1996","journal-title":"J Nucl Med"},{"key":"10.3413\/Nukmed-0686-14-07-12","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318289b345"}],"container-title":["Nuklearmedizin"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.3413\/Nukmed-0686-14-07.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T15:34:31Z","timestamp":1540395271000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.3413\/Nukmed-0686-14-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":12,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2017,12,26]]},"published-print":{"date-parts":[[2015,1]]}},"URL":"https:\/\/doi.org\/10.3413\/nukmed-0686-14-07","relation":{},"ISSN":["0029-5566","2567-6407"],"issn-type":[{"value":"0029-5566","type":"print"},{"value":"2567-6407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}