{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:51:02Z","timestamp":1778809862076,"version":"3.51.4"},"reference-count":24,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":306,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Community","award":["QLK1-CT-2000-00618"],"award-info":[{"award-number":["QLK1-CT-2000-00618"]}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"crossref","award":["PROMETEO-17\/2017"],"award-info":[{"award-number":["PROMETEO-17\/2017"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EVO-fund of Kuopio University Hospital","award":["5254"],"award-info":[{"award-number":["5254"]}]},{"name":"EVO-fund of Kuopio University Hospital","award":["5168"],"award-info":[{"award-number":["5168"]}]},{"name":"EVO-fund of Kuopio University Hospital","award":["5106"],"award-info":[{"award-number":["5106"]}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Juho Vainio Foundation"},{"DOI":"10.13039\/501100013500","name":"Finnish Diabetes Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013500","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","award":["283454"],"award-info":[{"award-number":["283454"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","award":["129330"],"award-info":[{"award-number":["129330"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","award":["128315"],"award-info":[{"award-number":["128315"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100016420","name":"California Walnut Commission","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016420","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sixth Framework Programme","award":["FP6-2005-513946"],"award-info":[{"award-number":["FP6-2005-513946"]}]},{"name":"Stanford Clinical and Translational Science Award"},{"name":"Nutrition Science Initiative","award":["T32HL007034"],"award-info":[{"award-number":["T32HL007034"]}]},{"name":"American Heart Association Scientist Development Award","award":["0730094N"],"award-info":[{"award-number":["0730094N"]}]},{"name":"United States\u2013Israel Binational Science Foundation","award":["2011036"],"award-info":[{"award-number":["2011036"]}]},{"name":"Boston Obesity Nutrition Research Center","award":["DK46200"],"award-info":[{"award-number":["DK46200"]}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK078616"],"award-info":[{"award-number":["DK078616"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK100383"],"award-info":[{"award-number":["DK100383"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK091718"],"award-info":[{"award-number":["DK091718"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["1R01DK091831"],"award-info":[{"award-number":["1R01DK091831"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["HL126024"],"award-info":[{"award-number":["HL126024"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["HL034594"],"award-info":[{"award-number":["HL034594"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["HL071981"],"award-info":[{"award-number":["HL071981"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["1K12GM088033"],"award-info":[{"award-number":["1K12GM088033"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Peking University Start-up Grant","award":["BMU2018YJ002"],"award-info":[{"award-number":["BMU2018YJ002"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2020YFC2003401"],"award-info":[{"award-number":["2020YFC2003401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Health Data Sci"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n            <jats:italic>Objective<\/jats:italic>\n            . The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (\n            <jats:italic>TCF7L2<\/jats:italic>\n            ). We aimed to quantify the interaction of diet\/lifestyle interventions and the genetic effect of\n            <jats:italic>TCF7L2<\/jats:italic>\n            rs7903146 on glycemic traits, body weight, or waist circumference in overweight or obese adults in several randomized controlled trials (RCTs).\n            <jats:italic>Methods<\/jats:italic>\n            . From October 2016 to May 2018, a large collaborative analysis was performed by pooling individual-participant data from 7 RCTs. These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary\/lifestyle-related interventions in overweight or obese adults. Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies.\n            <jats:italic>Results<\/jats:italic>\n            . In the joint analysis, a total of 7 eligible RCTs were included (\n            <jats:inline-formula>\n              <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                <mml:mi>n<\/mml:mi>\n                <mml:mo>=<\/mml:mo>\n                <mml:mn>4,114<\/mml:mn>\n              <\/mml:math>\n            <\/jats:inline-formula>\n            ). Importantly, we observed a significant effect modification of diet\/lifestyle-related interventions on the\n            <jats:italic>TCF7L2<\/jats:italic>\n            variant rs7903146 and changes in fasting glucose. Compared with the control group, diet\/lifestyle interventions were related to lower fasting glucose by -3.06 (95% CI, -5.77 to -0.36) mg\/dL (test for heterogeneity and overall effect:\n            <jats:inline-formula>\n              <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                <mml:msup>\n                  <mml:mrow>\n                    <mml:mi>I<\/mml:mi>\n                  <\/mml:mrow>\n                  <mml:mrow>\n                    <mml:mn>2<\/mml:mn>\n                  <\/mml:mrow>\n                <\/mml:msup>\n                <mml:mo>=<\/mml:mo>\n                <mml:mn>45.1<\/mml:mn>\n                <mml:mi>%<\/mml:mi>\n              <\/mml:math>\n            <\/jats:inline-formula>\n            ,\n            <jats:inline-formula>\n              <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                <mml:mi>p<\/mml:mi>\n                <mml:mo>&lt;<\/mml:mo>\n                <mml:mn>0.05<\/mml:mn>\n              <\/mml:math>\n            <\/jats:inline-formula>\n            ;\n            <jats:inline-formula>\n              <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                <mml:mi>z<\/mml:mi>\n                <mml:mo>=<\/mml:mo>\n                <mml:mn>2.20<\/mml:mn>\n              <\/mml:math>\n            <\/jats:inline-formula>\n            ,\n            <jats:inline-formula>\n              <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                <mml:mi>p<\/mml:mi>\n                <mml:mo>=<\/mml:mo>\n                <mml:mn>0.028<\/mml:mn>\n              <\/mml:math>\n            <\/jats:inline-formula>\n            ) per one copy of the\n            <jats:italic>TCF7L2<\/jats:italic>\n            T risk allele. Furthermore, regardless of genetic risk, diet\/lifestyle interventions were associated with lower waist circumference. However, there was no significant change for diet\/lifestyle interventions in other glycemic control and adiposity traits per one copy of\n            <jats:italic>TCF7L2<\/jats:italic>\n            risk allele.\n            <jats:italic>Conclusions<\/jats:italic>\n            . Our findings suggest that carrying the\n            <jats:italic>TCF7L2<\/jats:italic>\n            T risk allele may have a modestly greater benefit for specific diet\/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.\n          <\/jats:p>","DOI":"10.34133\/2021\/9897048","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T23:45:09Z","timestamp":1635983109000},"source":"Crossref","is-referenced-by-count":5,"title":["Interaction of Diet\/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide"],"prefix":"10.34133","volume":"2021","author":[{"given":"Tao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health, Peking University, China"},{"name":"Department of Global Health, School of Public Health, Peking University, China"},{"name":"Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education, China"},{"name":"Global Health Institute Peking University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhuang","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health, Peking University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoriko","family":"Heianza","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianjianyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health, Peking University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health, Peking University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics, School of Public Health, Peking University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-1294","authenticated-orcid":false,"given":"Emilio","family":"Ros","sequence":"additional","affiliation":[{"name":"Department of Endocrinology &amp; Nutrition, Institut d\u2019Investigacions Biom\u00e8diques August Pi Sunyer, Hospital Cl\u00ednic, Barcelona, Spain"},{"name":"CIBER Fisiopatologia de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liana C.","family":"Del Gobbo","sequence":"additional","affiliation":[{"name":"Stanford Prevention Research Center, Stanford University, Stanford CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-7459","authenticated-orcid":false,"given":"Jordi","family":"Salas-Salvad\u00f3","sequence":"additional","affiliation":[{"name":"CIBER Fisiopatologia de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain"},{"name":"Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-9808","authenticated-orcid":false,"given":"Miguel A.","family":"Mart\u00ednez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA"},{"name":"CIBER Fisiopatologia de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain"},{"name":"University of Navarra, Department of Preventive Medicine and Public Health, Medical School &amp; IDISNA, Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Polak","sequence":"additional","affiliation":[{"name":"Department for the Study of Obesity and Diabetes, Third Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3394-7749","authenticated-orcid":false,"given":"Markku","family":"Laakso","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Astrup","sequence":"additional","affiliation":[{"name":"University of Copenhagen, Department of Nutrition, Exercise and Sports, Faculty of Science, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Langin","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm), UMR1048, Institute of Metabolic and Cardiovascular Diseases, University of Toulouse and Paul Sabatier University, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorg","family":"Hager","sequence":"additional","affiliation":[{"name":"Nestl\u00e9 Institute of Health Sciences, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6763-4265","authenticated-orcid":false,"given":"Gabby","family":"Hul","sequence":"additional","affiliation":[{"name":"Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben","family":"Hansen","sequence":"additional","affiliation":[{"name":"Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluf","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Michel","family":"Oppert","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institute of Cardiometabolism and Nutrition (ICAN), Department of Nutrition, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim H. M.","family":"Saris","sequence":"additional","affiliation":[{"name":"Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Arner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit for Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Cof\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Endocrinology &amp; Nutrition, Institut d\u2019Investigacions Biom\u00e8diques August Pi Sunyer, Hospital Cl\u00ednic, Barcelona, Spain"},{"name":"CIBER Fisiopatologia de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6367-4406","authenticated-orcid":false,"given":"Sujatha","family":"Rajaram","sequence":"additional","affiliation":[{"name":"School of Public Health, Loma Linda University, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaakko","family":"Tuomilehto","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease Prevention, Finnish National Institute for Health and Welfare, HelsinkiFinland"},{"name":"Department of Public Health, University of Helsinki, Helsinki, Finland"},{"name":"Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaana","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease Prevention, Finnish National Institute for Health and Welfare, HelsinkiFinland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3414-6983","authenticated-orcid":false,"given":"Vanessa D.","family":"de Mello","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Stancacova","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Uusitupa","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Svendstrup","sequence":"additional","affiliation":[{"name":"Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Danish Diabetes Academy Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4821-430X","authenticated-orcid":false,"given":"Thorkild I. A.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7596-1530","authenticated-orcid":false,"given":"Christopher D.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Stanford Prevention Research Center, Stanford University, Stanford CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9063-9785","authenticated-orcid":false,"given":"Joan","family":"Sabat\u00e9","sequence":"additional","affiliation":[{"name":"School of Public Health, Loma Linda University, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Corella","sequence":"additional","affiliation":[{"name":"CIBER Fisiopatologia de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain"},{"name":"Department of Preventive Medicine, University of Valencia, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Alfredo","family":"Martinez","sequence":"additional","affiliation":[{"name":"CIBER Fisiopatologia de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain"},{"name":"Department of Nutrition Food Science and Physiology, University of Navarra, IDISNA, Pamplona and IMDEA, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA"},{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"issue":"10","key":"e_1_3_6_1_2","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrendo.2016.105","article-title":"Diabetes mellitus statistics on prevalence and mortality: facts and fallacies","volume":"12","author":"Zimmet P.","year":"2016","unstructured":"P.Zimmet, K. G.Alberti, D. J.Magliano, and P. H.Bennett, \u201cDiabetes mellitus statistics on prevalence and mortality: facts and fallacies,\u201d Nature Reviews. Endocrinology, vol. 12, no. 10, pp. 616\u2013622, 2016","journal-title":"Nature Reviews. Endocrinology"},{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062418"},{"issue":"4","key":"e_1_3_6_3_2","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3945\/ajcn.2008.27058","article-title":"TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women","volume":"89","author":"Cornelis M. C.","year":"2009","unstructured":"M. C.Cornelis, L.Qi, P.Kraft, and F. B.Hu, \u201cTCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women,\u201d The American Journal of Clinical Nutrition, vol. 89, no. 4, pp. 1256\u20131262, 2009","journal-title":"The American Journal of Clinical Nutrition"},{"issue":"5","key":"e_1_3_6_4_2","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3945\/ajcn.112.038125","article-title":"TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention","volume":"96","author":"Mattei J.","year":"2012","unstructured":"J.Mattei, Q.Qi, F. B.Hu, F. M.Sacks, and L.Qi, \u201cTCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention,\u201d The American Journal of Clinical Nutrition, vol. 96, no. 5, pp. 1129\u20131136, 2012","journal-title":"The American Journal of Clinical Nutrition"},{"issue":"1","key":"e_1_3_6_5_2","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1038\/s41467-018-04951-w","article-title":"Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes","volume":"9","author":"eQTLGen Consortium","year":"2018","unstructured":"eQTLGen Consortium, A.Xue, Y.Wu, Z.Zhu, F.Zhang, K. E.Kemper, Z.Zheng, L.Yengo, L. R.Lloyd-Jones, J.Sidorenko, Y.Wu, A. F.McRae, P. M.Visscher, J.Zeng, and J.Yang, \u201cGenome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes,\u201d Nature Communications, vol. 9, no. 1, p. 2941, 2018","journal-title":"Nature Communications"},{"issue":"3","key":"e_1_3_6_6_2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ng1732","article-title":"Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes","volume":"38","author":"Grant S. F.","year":"2006","unstructured":"S. F.Grant, G.Thorleifsson, I.Reynisdottir, R.Benediktsson, A.Manolescu, J.Sainz, A.Helgason, H.Stefansson, V.Emilsson, A.Helgadottir, U.Styrkarsdottir, K. P.Magnusson, G. B.Walters, E.Palsdottir, T.Jonsdottir, T.Gudmundsdottir, A.Gylfason, J.Saemundsdottir, R. L.Wilensky, M. P.Reilly, D. J.Rader, Y.Bagger, C.Christiansen, V.Gudnason, G.Sigurdsson, U.Thorsteinsdottir, J. R.Gulcher, A.Kong, and K.Stefansson, \u201cVariant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes,\u201d Nature Genetics, vol. 38, no. 3, pp. 320\u2013323, 2006","journal-title":"Nature Genetics"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2015-1146"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.77"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1050"},{"issue":"3","key":"e_1_3_6_10_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jnutbio.2010.11.020","article-title":"Dietary saturated fat, gender and genetic variation at the _TCF7L2_ locus predict the development of metabolic syndrome","volume":"23","author":"Phillips C. M.","year":"2012","unstructured":"C. M.Phillips, L.Goumidi, S.Bertrais, M. R.Field, R.McManus, S.Hercberg, D.Lairon, R.Planells, and H. M.Roche, \u201cDietary saturated fat, gender and genetic variation at the _TCF7L2_ locus predict the development of metabolic syndrome,\u201d The Journal of Nutritional Biochemistry, vol. 23, no. 3, pp. 239\u2013244, 2012","journal-title":"The Journal of Nutritional Biochemistry"},{"issue":"6","key":"e_1_3_6_11_2","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.3945\/ajcn.111.014670","article-title":"Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain","volume":"95","author":"Fisher E.","year":"2012","unstructured":"E.Fisher, K.Meidtner, L.\u00c4ngquist, C.Holst, R. D.Hansen, J.Halkj\u0153r, G.Masala, J. N.\u00d8stergaard, K.Overvad, D.Palli, K. S.Vimaleswaran, A.Tj\u00f8nneland, D. L.van der A, N. J.Wareham, T. I. A.S\u00f8rensen, R. J. F.Loos, and H.Boeing, \u201cInfluence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain,\u201d American Journal of Clinical Nutrition, vol. 95, no. 6, pp. 1468\u20131476, 2012","journal-title":"American Journal of Clinical Nutrition"},{"issue":"6","key":"e_1_3_6_12_2","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1007\/s00125-007-0656-6","article-title":"Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion","volume":"50","author":"Wang J.","year":"2007","unstructured":"J.Wang, J.Kuusisto, M.V\u00e4nttinen, T.Kuulasmaa, J.Lindstr\u00f6m, J.Tuomilehto, M.Uusitupa, and M.Laakso, \u201cVariants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion,\u201d Diabetologia, vol. 50, no. 6, pp. 1192\u20131200, 2007","journal-title":"Diabetologia"},{"issue":"11","key":"e_1_3_6_13_2","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.2337\/dc13-0955","article-title":"Mediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: a randomized controlled trial in a high-cardiovascular-risk population","volume":"36","author":"Corella D.","year":"2013","unstructured":"D.Corella, P.Carrasco, J. V.Sorli, R.Estruch, J.Rico-Sanz, M. A.Martinez-Gonzalez, J.Salas-Salvado, M. I.Covas, O.Coltell, F.Aros, J.Lapetra, L.Serra-Majem, V.Ruiz-Gutierrez, J.Warnberg, M.Fiol, X.Pinto, C.Ortega-Azorin, M. A.Munoz, J. A.Martinez, E.Gomez-Gracia, J. I.Gonzalez, E.Ros, and J. M.Ordovas, \u201cMediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: a randomized controlled trial in a high-cardiovascular-risk population,\u201d Diabetes Care, vol. 36, no. 11, pp. 3803\u20133811, 2013","journal-title":"Diabetes Care"},{"issue":"7","key":"e_1_3_6_14_2","doi-asserted-by":"crossref","first-page":"e21518","DOI":"10.1371\/journal.pone.0021518","article-title":"TCF7L2 polymorphism, weight loss and proinsulin: insulin ratio in the Diabetes Prevention Program","volume":"6","author":"McCaffery J. M.","year":"2011","unstructured":"J. M.McCaffery, K. A.Jablonski, P. W.Franks, S.Dagogo-Jack, R. R.Wing, W. C.Knowler, L.Delahanty, D.Dabelea, R.Hamman, A. R.Shuldiner, J. C.Florez, and for the Diabetes Prevention Program Research Group, \u201cTCF7L2 polymorphism, weight loss and proinsulin: insulin ratio in the Diabetes Prevention Program,\u201d PLoS One, vol. 6, no. 7, p. e21518, 2011","journal-title":"PLoS One"},{"issue":"05","key":"e_1_3_6_15_2","doi-asserted-by":"crossref","first-page":"c221","DOI":"10.1136\/bmj.c221","article-title":"Meta-analysis of individual participant data: rationale, conduct, and reporting","volume":"340","author":"Riley R. D.","year":"2010","unstructured":"R. D.Riley, P. C.Lambert, and G.Abo-Zaid, \u201cMeta-analysis of individual participant data: rationale, conduct, and reporting,\u201d BMJ, vol. 340, no. feb05 1, p. c221, 2010","journal-title":"BMJ"},{"key":"e_1_3_6_16_2","doi-asserted-by":"crossref","first-page":"i4707","DOI":"10.1136\/bmj.i4707","article-title":"FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials","volume":"354","author":"Livingstone K. M.","year":"2016","unstructured":"K. M.Livingstone, C.Celis-Morales, G. D.Papandonatos, B.Erar, J. C.Florez, K. A.Jablonski, C.Razquin, A.Marti, Y.Heianza, T.Huang, F. M.Sacks, M.Svendstrup, X.Sui, T. S.Church, T.J\u00e4\u00e4skel\u00e4inen, J.Lindstr\u00f6m, J.Tuomilehto, M.Uusitupa, T.Rankinen, W. H. M.Saris, T.Hansen, O.Pedersen, A.Astrup, T. I. A.S\u00f8rensen, L.Qi, G. A.Bray, M. A.Martinez-Gonzalez, J. A.Martinez, P. W.Franks, J. M.McCaffery, J.Lara, and J. C.Mathers, \u201cFTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials,\u201d BMJ, vol. 354, p. i4707, 2016","journal-title":"BMJ"},{"issue":"11","key":"e_1_3_6_17_2","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins J. P.","year":"2002","unstructured":"J. P.Higgins, and S. G.Thompson, \u201cQuantifying heterogeneity in a meta-analysis,\u201d Statistics in Medicine, vol. 21, no. 11, pp. 1539\u20131558, 2002","journal-title":"Statistics in Medicine"},{"issue":"2","key":"e_1_3_6_18_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jrsm.12","article-title":"A basic introduction to fixed-effect and random-effects models for meta-analysis","volume":"1","author":"Borenstein M.","year":"2010","unstructured":"M.Borenstein, L. V.Hedges, J. P.Higgins, and H. R.Rothstein, \u201cA basic introduction to fixed-effect and random-effects models for meta-analysis,\u201d Research Synthesis Methods, vol. 1, no. 2, pp. 97\u2013111, 2010","journal-title":"Research Synthesis Methods"},{"issue":"6","key":"e_1_3_6_19_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2188\/jea.15.235","article-title":"Systematic evaluation and comparison of statistical tests for publication bias","volume":"15","author":"Hayashino Y.","year":"2005","unstructured":"Y.Hayashino, Y.Noguchi, and T.Fukui, \u201cSystematic evaluation and comparison of statistical tests for publication bias,\u201d Journal of Epidemiology, vol. 15, no. 6, pp. 235\u2013243, 2005","journal-title":"Journal of Epidemiology"},{"issue":"7109","key":"e_1_3_6_20_2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger M.","year":"1997","unstructured":"M.Egger, G.Davey Smith, M.Schneider, and C.Minder, \u201cBias in meta-analysis detected by a simple, graphical test,\u201d BMJ, vol. 315, no. 7109, pp. 629\u2013634, 1997","journal-title":"BMJ"},{"issue":"7","key":"e_1_3_6_21_2","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.cell.2012.10.053","article-title":"Diabetes risk gene and Wnt effector _Tcf7l2_ \/TCF4 controls hepatic response to perinatal and adult metabolic demand","volume":"151","author":"Boj S. F.","year":"2012","unstructured":"S. F.Boj, J. H.van Es, M.Huch, V. S. W.Li, A.Jos\u00e9, P.Hatzis, M.Mokry, A.Haegebarth, M.van den Born, P.Chambon, P.Voshol, Y.Dor, E.Cuppen, C.Fillat, and H.Clevers, \u201cDiabetes risk gene and Wnt effector _Tcf7l2_ \/TCF4 controls hepatic response to perinatal and adult metabolic demand,\u201d Cell, vol. 151, no. 7, pp. 1595\u20131607, 2012","journal-title":"Cell"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2011.12.012"},{"issue":"1","key":"e_1_3_6_23_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1677\/JOE-10-0044","article-title":"Insulin treatment and high-fat diet feeding reduces the expression of three Tcf genes in rodent pancreas","volume":"207","author":"Columbus J.","year":"2010","unstructured":"J.Columbus, Y. T.Chiang, W. J.Shao, N. N.Zhang, D. Y.Wang, H. Y.Gaisano, Q.Wang, D. M.Irwin, and T.Jin, \u201cInsulin treatment and high-fat diet feeding reduces the expression of three Tcf genes in rodent pancreas,\u201d The Journal of Endocrinology, vol. 207, no. 1, pp. 77\u201386, 2010","journal-title":"The Journal of Endocrinology"},{"issue":"2","key":"e_1_3_6_24_2","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3945\/ajcn.2009.27947","article-title":"TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet","volume":"91","author":"Grau K.","year":"2010","unstructured":"K.Grau, S.Cauchi, C.Holst, A.Astrup, J. A.Martinez, W. H. M.Saris, E. E.Blaak, J. M.Oppert, P.Arner, S.R\u00f6ssner, I. A.Macdonald, E.Klimcakova, D.Langin, O.Pedersen, P.Froguel, and T. I. A.S\u00f8rensen, \u201cTCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet,\u201d American Journal of Clinical Nutrition, vol. 91, no. 2, pp. 472\u2013479, 2010","journal-title":"American Journal of Clinical Nutrition"}],"container-title":["Health Data Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.spj.sciencemag.org\/hds\/2021\/9897048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.34133\/2021\/9897048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T14:06:42Z","timestamp":1704809202000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.34133\/2021\/9897048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":24,"alternative-id":["10.34133\/2021\/9897048"],"URL":"https:\/\/doi.org\/10.34133\/2021\/9897048","relation":{},"ISSN":["2765-8783"],"issn-type":[{"value":"2765-8783","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"9897048"}}