{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:12:07Z","timestamp":1790727127646,"version":"4.1.0"},"reference-count":50,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":268,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taishan Scholars Program for Young Expert of Shandong Province"},{"DOI":"10.13039\/100012515","name":"Cyrus Tang Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012515","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009108","name":"Shandong University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Research"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n            Sepsis is a life-threatening organ dysfunction characterized by severe systemic inflammatory response to infection. Effective treatment of bacterial sepsis remains a paramount clinical challenge, due to its astonishingly rapid progression and the prevalence of bacterial drug resistance. Here, we present a decoy nanozyme-enabled intervention strategy for multitarget blockade of proinflammatory cascades to treat multi-drug-resistant (MDR) bacterial sepsis. The decoy nanozymes (named MCeC@M\n            <jats:italic>\u03a6<\/jats:italic>\n            ) consist mesoporous silica nanoparticle cores loaded with CeO\n            <jats:sub>2<\/jats:sub>\n            nanocatalyst and Ce6 photosensitizer and biomimetic shells of macrophage membrane. By acting as macrophage decoys, MCeC@M\n            <jats:italic>\u03a6<\/jats:italic>\n            allow targeted photodynamic eradication of MDR bacteria and realize simultaneous endotoxin\/proinflammatory cytokine neutralization. Meanwhile, MCeC@M\n            <jats:italic>\u03a6<\/jats:italic>\n            possess intriguing superoxide dismutase and catalase-like activities as well as hydroxyl radical antioxidant capacity and enable catalytic scavenging of multiple reactive oxygen species (ROS). These unique capabilities make MCeC@M\n            <jats:italic>\u03a6<\/jats:italic>\n            to collaboratively address the issues of bacterial infection, endotoxin\/proinflammatory cytokine secretion, and ROS burst, fully cutting off the path of proinflammatory cascades to reverse the progression of bacterial sepsis.\n            <jats:italic>In vivo<\/jats:italic>\n            experiments demonstrate that MCeC@M\n            <jats:italic>\u03a6<\/jats:italic>\n            considerably attenuate systemic hyperinflammation and rapidly rescue organ damage within 1 day to confer higher survival rates (&gt;75%) to mice with progressive MDR\n            <jats:italic>Escherichia coli<\/jats:italic>\n            bacteremia. The proposed decoy nanozyme-enabled multitarget collaborative intervention strategy offers a powerful modality for bacterial sepsis management and opens up possibilities for the treatment of cytokine storm in the COVID-19 pandemic and immune-mediated inflammation diseases.\n          <\/jats:p>","DOI":"10.34133\/2022\/9767643","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T23:45:09Z","timestamp":1664235909000},"source":"Crossref","is-referenced-by-count":39,"title":["Decoy Nanozymes Enable Multitarget Blockade of Proinflammatory Cascades for the Treatment of Multi-Drug-Resistant Bacterial Sepsis"],"prefix":"10.34133","volume":"2022","author":[{"given":"Xuancheng","family":"Du","sequence":"first","affiliation":[{"name":"Institute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Xi\u2019an Key Laboratory of Immune Related Diseases, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiting","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Pediatric Research, Children\u2019s Hospital of Soochow University, Suzhou 215025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center of Shandong University, Jinan 250012China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, the First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Qu","sequence":"additional","affiliation":[{"name":"Institute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-2908","authenticated-orcid":false,"given":"Weifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0032-1459","authenticated-orcid":false,"given":"Kangsheng","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-3020","authenticated-orcid":false,"given":"Yong-Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan 250100, China"},{"name":"Suzhou Research Institute, Shandong University, Suzhou 215123, China"},{"name":"College of Chemistry, Chemical Engineering and Materials Science, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"issue":"10141","key":"e_1_3_5_1_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi M.","year":"2018","unstructured":"M. Cecconi, L. Evans, M. Levy, and A. Rhodes, \u201cSepsis and septic shock,\u201d Lancet, vol. 392, no. 10141, pp. 75\u201387, 2018","journal-title":"Lancet"},{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01326"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c04759"},{"issue":"5","key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1056\/NEJMp1707170","article-title":"Recognizing sepsis as a global health priority - a WHO resolution","volume":"377","author":"Reinhark K.","year":"2017","unstructured":"K. Reinhark, R. Daniels, N. Kissoon, F. R. Machado, R. D. Schachter, and S. Finfer, \u201cRecognizing sepsis as a global health priority - a WHO resolution,\u201d New England Journal of Medicine, vol. 377, no. 5, pp. 414\u2013417, 2017","journal-title":"New England Journal of Medicine"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0752-4"},{"issue":"1","key":"e_1_3_5_6_2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1039\/C7NR06373C","article-title":"Bacterial species-identifiable magnetic nanosystems for early sepsis diagnosis and extracorporeal photodynamic blood disinfection","volume":"10","author":"Wang J.","year":"2018","unstructured":"J. Wang, H. Wu, Y. Yang, R. Yan, Y. Zhao, Y. Wang, A. Chen, S. Shao, P. Jiang, and Y. Q. Li, \u201cBacterial species-identifiable magnetic nanosystems for early sepsis diagnosis and extracorporeal photodynamic blood disinfection,\u201d Nanoscale, vol. 10, no. 1, pp. 132\u2013141, 2018","journal-title":"Nanoscale"},{"issue":"570","key":"e_1_3_5_7_2","article-title":"Repurposing a neurodegenerative disease drug to treat gram-negative antibiotic-resistant bacterial sepsis","volume":"12","author":"De Oliveira D. M. P.","year":"2020","unstructured":"D. M. P. De Oliveira, L. Bohlmann, T. Conroy, F. E. C. Jen, A. Everest-Dass, K. A. Hansford, R. Bolisetti, I. M. El-Deeb, B. M. Forde, M. D. Phan, and J. A. Lacey, \u201cRepurposing a neurodegenerative disease drug to treat gram-negative antibiotic-resistant bacterial sepsis,\u201d Science Translational Medicine, vol. 12, no. 570, article eabb3791, 2020","journal-title":"Science Translational Medicine"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b05608"},{"issue":"2","key":"e_1_3_5_9_2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1164\/rccm.2009005","article-title":"A randomized phase II trial of granulocyte-macrophage colony-stimulating factor therapy in severe sepsis with respiratory dysfunction","volume":"166","author":"Presneill J. J.","year":"2002","unstructured":"J. J. Presneill, T. Harris, A. G. Stewart, J. F. Cade, and J. W. Wilson, \u201cA randomized phase II trial of granulocyte-macrophage colony-stimulating factor therapy in severe sepsis with respiratory dysfunction,\u201d American Journal of Respiratory Critical Care Medicine, vol. 166, no. 2, pp. 138\u2013143, 2002","journal-title":"American Journal of Respiratory Critical Care Medicine"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/339549"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82224"},{"issue":"1","key":"e_1_3_5_12_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41565-019-0600-1","article-title":"Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis","volume":"15","author":"Hou X.","year":"2020","unstructured":"X. Hou, X. Zhang, W. Zhao, C. Zeng, B. Deng, D. W. McComb, S. du, C. Zhang, W. Li, and Y. Dong, \u201cVitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis,\u201d Nature Nanotechnology, vol. 15, no. 1, pp. 41\u201346, 2020","journal-title":"Nature Nanotechnology"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.25436"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR02706A"},{"key":"e_1_3_5_15_2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s10020-018-0029-2","article-title":"B-1a cells protect mice from sepsis-induced acute lung injury","volume":"24","author":"Aziz M.","year":"2018","unstructured":"M. Aziz, Y. Ode, M. Zhou, M. Ochani, N. E. Holodick, T. L. Rothstein, and P. Wang, \u201cB-1a cells protect mice from sepsis-induced acute lung injury,\u201d Molecular Medicine, vol. 24, p. 26, 2018","journal-title":"Molecular Medicine"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.02.006"},{"issue":"13","key":"e_1_3_5_17_2","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1002\/anie.201912182","article-title":"An enzyme-mimicking single-atom catalyst as an efficient multiple reactive oxygen and nitrogen species scavenger for sepsis management","volume":"59","author":"Cao F.","year":"2020","unstructured":"F. Cao, L. Zhang, Y. You, L. Zheng, J. Ren, and X. Qu, \u201cAn enzyme-mimicking single-atom catalyst as an efficient multiple reactive oxygen and nitrogen species scavenger for sepsis management,\u201d Angewandte Chemie-International Edition, vol. 59, no. 13, pp. 5108\u20135115, 2020","journal-title":"Angewandte Chemie-International Edition"},{"issue":"23","key":"e_1_3_5_18_2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3000678","article-title":"Targeting Robo4-dependent slit signaling to survive the cytokine storm in sepsis and influenza","volume":"2","author":"London N. R.","year":"2010","unstructured":"N. R. London, W. Zhu, F. A. Bozza, M. C. P. Smith, D. M. Greif, L. K. Sorensen, L. Chen, Y. Kaminoh, A. C. Chan, S. F. Passi, C. W. Day, D. L. Barnard, G. A. Zimmerman, M. A. Krasnow, and D. Y. Li, \u201cTargeting Robo4-dependent slit signaling to survive the cytokine storm in sepsis and influenza,\u201d Science Translational Medicine, vol. 2, no. 23, 2010","journal-title":"Science Translational Medicine"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00672"},{"key":"e_1_3_5_20_2","doi-asserted-by":"crossref","first-page":"101269","DOI":"10.1016\/j.nantod.2021.101269","article-title":"Nanozymes: a clear definition with fuzzy edges","volume":"40","author":"Wei H.","year":"2021","unstructured":"H. Wei, L. Gao, K. Fan, J. Liu, J. He, X. Qu, S. Dong, E. Wang, and X. Yan, \u201cNanozymes: a clear definition with fuzzy edges,\u201d Nano Today, vol. 40, p. 101269, 2021","journal-title":"Nano Today"},{"issue":"7","key":"e_1_3_5_21_2","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1021\/accountsmr.1c00074","article-title":"Nanozymes inspired by natural enzymes","volume":"2","author":"Zhang R.","year":"2021","unstructured":"R. Zhang, X. Yan, and K. Fan, \u201cNanozymes inspired by natural enzymes,\u201d Accounts of Materials Research, vol. 2, no. 7, pp. 534\u2013547, 2021","journal-title":"Accounts of Materials Research"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210005"},{"key":"e_1_3_5_23_2","doi-asserted-by":"crossref","first-page":"101317","DOI":"10.1016\/j.nantod.2021.101317","article-title":"Unveiling the active sites on ferrihydrite with apparent catalase-like activity for potentiating radiotherapy","volume":"41","author":"Zhang R.","year":"2021","unstructured":"R. Zhang, L. Chen, Q. Liang, J. Xi, H. Zhao, Y. Jin, X. Gao, X. Yan, L. Gao, and K. Fan, \u201cUnveiling the active sites on ferrihydrite with apparent catalase-like activity for potentiating radiotherapy,\u201d Nano Today, vol. 41, p. 101317, 2021","journal-title":"Nano Today"},{"key":"e_1_3_5_24_2","article-title":"Bioinspired copper single-atom nanozyme as a superoxide dismutase-like antioxidant for sepsis treatment","volume":"2","author":"Yang J.","year":"2022","unstructured":"J. Yang, R. Zhang, H. Zhao, H. Qi, J. Li, J. F. Li, X. Zhou, A. Wang, K. Fan, X. Yan, and T. Zhang, \u201cBioinspired copper single-atom nanozyme as a superoxide dismutase-like antioxidant for sepsis treatment,\u201d Exploration, vol. 2, article 20210267, 2022","journal-title":"Exploration"},{"issue":"9","key":"e_1_3_5_25_2","doi-asserted-by":"crossref","first-page":"2007130","DOI":"10.1002\/adfm.202007130","article-title":"A nanozyme-based artificial peroxisome ameliorates hyperuricemia and ischemic stroke","volume":"31","author":"Xi J.","year":"2021","unstructured":"J. Xi, R. Zhang, L. Wang, W. Xu, Q. Liang, J. Li, J. Jiang, Y. Yang, X. Yan, K. Fan, and L. Gao, \u201cA nanozyme-based artificial peroxisome ameliorates hyperuricemia and ischemic stroke,\u201d Advanced Functional Materials, vol. 31, no. 9, p. 2007130, 2021","journal-title":"Advanced Functional Materials"},{"issue":"38","key":"e_1_3_5_26_2","doi-asserted-by":"crossref","first-page":"11399","DOI":"10.1002\/anie.201704904","article-title":"Ceria\u2013zirconia nanoparticles as an enhanced multi-antioxidant for sepsis treatment","volume":"56","author":"Soh M.","year":"2017","unstructured":"M. Soh, D. Kang, H. Jeong, D. Kim, D. Y. Kim, W. Yang, C. Song, S. Baik, I. Y. Choi, S. K. Ki, H. J. Kwon, T. Kim, C. K. Kim, S. H. Lee, and T. Hyeon, \u201cCeria\u2013zirconia nanoparticles as an enhanced multi-antioxidant for sepsis treatment,\u201d Angewandte Chemie-International Edition, vol. 56, no. 38, pp. 11399\u201311403, 2017","journal-title":"Angewandte Chemie-International Edition"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9MH00339H"},{"issue":"14","key":"e_1_3_5_28_2","article-title":"Combating biofilm associated infection in vivo: integration of quorum sensing inhibition and photodynamic treatment based on multidrug delivered hollow carbon nitride sphere","volume":"29","author":"Sun Y.","year":"2019","unstructured":"Y. Sun, H. Qin, Z. Yan, C. Zhao, J. Ren, and X. Qu, \u201cCombating biofilm associated infection in vivo: integration of quorum sensing inhibition and photodynamic treatment based on multidrug delivered hollow carbon nitride sphere,\u201d Advanced Functional Materials, vol. 29, no. 14, article 1808222, 2019","journal-title":"Advanced Functional Materials"},{"issue":"23","key":"e_1_3_5_29_2","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1039\/D0CC08340B","article-title":"Elimination of macrophage-entrapped antibiotic-resistant bacteria by a targeted metal\u2013organic framework-based nanoplatform","volume":"57","author":"Liu X.","year":"2021","unstructured":"X. Liu, Q. Deng, L. Zhang, Y. Sang, K. Dong, J. Ren, and X. Qu, \u201cElimination of macrophage-entrapped antibiotic-resistant bacteria by a targeted metal\u2013organic framework-based nanoplatform,\u201d Chemical Communications, vol. 57, no. 23, pp. 2903\u20132906, 2021","journal-title":"Chemical Communications"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4368"},{"key":"e_1_3_5_31_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.intimp.2016.04.041","article-title":"Targeting cytokines as a treatment for patients with sepsis: a lost cause or a strategy still worthy of pursuit?","volume":"36","author":"Brown K. A.","year":"2016","unstructured":"K. A. Brown, G. A. Brown, S. M. Lewis, R. Beale, and D. F. Treacher, \u201cTargeting cytokines as a treatment for patients with sepsis: a lost cause or a strategy still worthy of pursuit?,\u201d International Immunopharmacology, vol. 36, pp. 291\u2013299, 2016","journal-title":"International Immunopharmacology"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b07625"},{"issue":"5","key":"e_1_3_5_33_2","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.1021\/acsnano.7b00041","article-title":"Bacteria-activated theranostic nanoprobes against methicillin-resistant Staphylococcus aureus infection","volume":"11","author":"Zhao Z.","year":"2017","unstructured":"Z. Zhao, R. Yan, X. Yi, J. Li, J. Rao, Z. Guo, Y. Yang, W. Li, Y. Q. Li, and C. Chen, \u201cBacteria-activated theranostic nanoprobes against methicillin-resistant Staphylococcus aureus infection,\u201d ACS Nano, vol. 11, no. 5, pp. 4428\u20134438, 2017","journal-title":"ACS Nano"},{"key":"e_1_3_5_34_2","article-title":"Biofilm microenvironment-responsive nanotheranostics for dual-mode imaging and hypoxia-relief-enhanced photodynamic therapy of bacterial infections","volume":"2020","author":"Xiu W.","year":"2020","unstructured":"W. Xiu, S. Gan, Q. Wen, Q. Qiu, S. Dai, H. Dong, Q. Li, L. Yuwen, L. Weng, Z. Teng, and Y. Mou, \u201cBiofilm microenvironment-responsive nanotheranostics for dual-mode imaging and hypoxia-relief-enhanced photodynamic therapy of bacterial infections,\u201d Research, vol. 2020, article 9426453, \u201315, 2020","journal-title":"Research"},{"issue":"48","key":"e_1_3_5_35_2","article-title":"Coating of a novel antimicrobial nanoparticle with a macrophage membrane for the selective entry into infected macrophages and killing of intracellular staphylococci","volume":"30","author":"Li Y.","year":"2020","unstructured":"Y. Li, Y. Liu, Y. Ren, L. Su, A. Li, Y. An, V. Rotello, Z. Zhang, Y. Wang, Y. Liu, and S. Liu, \u201cCoating of a novel antimicrobial nanoparticle with a macrophage membrane for the selective entry into infected macrophages and killing of intracellular staphylococci,\u201d Advanced Functional Materials, vol. 30, no. 48, article 2004942, 2020","journal-title":"Advanced Functional Materials"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c01654"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714267114"},{"issue":"12","key":"e_1_3_5_38_2","doi-asserted-by":"crossref","first-page":"12096","DOI":"10.1021\/acsnano.8b05292","article-title":"Cell-membrane immunotherapy based on natural killer cell membrane coated nanoparticles for the effective inhibition of primary and abscopal tumor growth","volume":"12","author":"Deng G.","year":"2018","unstructured":"G. Deng, Z. Sun, S. Li, X. Peng, W. Li, L. Zhou, Y. Ma, P. Gong, and L. Cai, \u201cCell-membrane immunotherapy based on natural killer cell membrane coated nanoparticles for the effective inhibition of primary and abscopal tumor growth,\u201d ACS Nano, vol. 12, no. 12, pp. 12096\u201312108, 2018","journal-title":"ACS Nano"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2014352117"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.01.064"},{"key":"e_1_3_5_41_2","article-title":"MOF-encapsulated nanozyme enhanced siRNA combo: control neural stem cell differentiation and ameliorate cognitive impairments in Alzheimer's disease model","volume":"255","author":"Yu D.","year":"2020","unstructured":"D. Yu, M. Ma, Z. Liu, Z. Pi, X. du, J. Ren, and X. Qu, \u201cMOF-encapsulated nanozyme enhanced siRNA combo: control neural stem cell differentiation and ameliorate cognitive impairments in Alzheimer's disease model,\u201d Biomaterials, vol. 255, article 120160, 2020","journal-title":"Biomaterials"},{"issue":"3","key":"e_1_3_5_42_2","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1021\/acsnano.8b08785","article-title":"Synergistic oxygen generation and reactive oxygen species scavenging by manganese ferrite\/ceria co-decorated nanoparticles for rheumatoid arthritis treatment","volume":"13","author":"Kim J.","year":"2019","unstructured":"J. Kim, H. Y. Kim, S. Y. Song, S. H. Go, H. S. Sohn, S. Baik, M. Soh, K. Kim, D. Kim, H. C. Kim, N. Lee, B. S. Kim, and T. Hyeon, \u201cSynergistic oxygen generation and reactive oxygen species scavenging by manganese ferrite\/ceria co-decorated nanoparticles for rheumatoid arthritis treatment,\u201d ACS Nano, vol. 13, no. 3, pp. 3206\u20133217, 2019","journal-title":"ACS Nano"},{"issue":"1","key":"e_1_3_5_43_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12951-021-01215-6","article-title":"pH-switchable nanozyme cascade catalysis: a strategy for spatial-temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer","volume":"20","author":"Du X.","year":"2022","unstructured":"X. Du, B. Jia, W. Wang, C. Zhang, X. Liu, Y. Qu, M. Zhao, W. Li, Y. Yang, and Y. Q. Li, \u201cpH-switchable nanozyme cascade catalysis: a strategy for spatial-temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer,\u201d Journal of Nanobiotechnology, vol. 20, no. 1, p. 12, 2022","journal-title":"Journal of Nanobiotechnology"},{"key":"e_1_3_5_44_2","article-title":"A versatile nanocomposite based on nanoceria for antibacterial enhancement and protection from aPDT-aggravated inflammation via modulation of macrophage polarization","volume":"268","author":"Sun Y.","year":"2021","unstructured":"Y. Sun, X. Sun, X. Li, W. Li, C. Li, Y. Zhou, L. Wang, and B. Dong, \u201cA versatile nanocomposite based on nanoceria for antibacterial enhancement and protection from aPDT-aggravated inflammation via modulation of macrophage polarization,\u201d Biomaterials, vol. 268, article 120614, 2021","journal-title":"Biomaterials"},{"issue":"42","key":"e_1_3_5_45_2","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.1002\/adfm.201502728","article-title":"Light-up probe for targeted and activatable photodynamic therapy with real- time in situ reporting of sensitizer activation and therapeutic responses","volume":"25","author":"Yuan Y.","year":"2015","unstructured":"Y. Yuan, C. J. Zhang, R. T. K. Kwok, S. Xu, R. Zhang, J. Wu, B. Z. Tang, and B. Liu, \u201cLight-up probe for targeted and activatable photodynamic therapy with real- time in situ reporting of sensitizer activation and therapeutic responses,\u201d Advanced Functional Materials, vol. 25, no. 42, pp. 6586\u20136595, 2015","journal-title":"Advanced Functional Materials"},{"issue":"43","key":"e_1_3_5_46_2","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201803618","article-title":"Bioresponsive nanoparticles targeted to infectious microenvironments for sepsis management","volume":"30","author":"Zhang C. Y.","year":"2018","unstructured":"C. Y. Zhang, J. Gao, and Z. Wang, \u201cBioresponsive nanoparticles targeted to infectious microenvironments for sepsis management,\u201d Advanced Materials, vol. 30, no. 43, article 1803618, 2018","journal-title":"Advanced Materials"},{"key":"e_1_3_5_47_2","article-title":"Bacterial template synthesis of multifunctional nanospindles for glutathione detection and enhanced cancer-specific chemo-chemodynamic therapy","volume":"2020","author":"Bao Y. W.","year":"2020","unstructured":"Y. W. Bao, X. W. Hua, J. Zeng, and F. G. Wu, \u201cBacterial template synthesis of multifunctional nanospindles for glutathione detection and enhanced cancer-specific chemo-chemodynamic therapy,\u201d Research, vol. 2020, article 9301215, \u201315, 2020","journal-title":"Research"},{"issue":"10229","key":"e_1_3_5_48_2","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta P.","year":"2020","unstructured":"P. Mehta, D. F. McAuley, M. Brown, E. Sanchez, R. S. Tattersall, J. J. Manson, and HLH Across Speciality Collaboration, UK, \u201cCOVID-19: consider cytokine storm syndromes and immunosuppression,\u201d Lancet, vol. 395, no. 10229, pp. 1033\u20131034, 2020","journal-title":"Lancet"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00435-x"},{"issue":"25","key":"e_1_3_5_50_2","article-title":"Biomimetic nanomedicine coupled with neoadjuvant chemotherapy to suppress breast cancer metastasis via tumor microenvironment remodeling","volume":"31","author":"Liu H.","year":"2021","unstructured":"H. Liu, J. Wang, M. Wang, Y. Wang, S. Shi, X. Hu, Q. Zhang, D. Fan, and P. Xu, \u201cBiomimetic nanomedicine coupled with neoadjuvant chemotherapy to suppress breast cancer metastasis via tumor microenvironment remodeling,\u201d Advanced Functional Materials, vol. 31, no. 25, article 2100262, 2021","journal-title":"Advanced Functional Materials"}],"container-title":["Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.spj.sciencemag.org\/research\/2022\/9767643.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.34133\/2022\/9767643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T15:56:01Z","timestamp":1704815761000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.34133\/2022\/9767643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":50,"alternative-id":["10.34133\/2022\/9767643"],"URL":"https:\/\/doi.org\/10.34133\/2022\/9767643","relation":{},"ISSN":["2639-5274"],"issn-type":[{"value":"2639-5274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"2022\/9767643"}}