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Laser-treated surfaces for ventricular assist devices.\n                    <jats:italic>Impact Statement<\/jats:italic>\n                    . This work has scientific impact since it proposes a biofunctional surface created with laser processing in bioinert titanium.\n                    <jats:italic>Introduction<\/jats:italic>\n                    . Cardiovascular diseases are the world\u2019s leading cause of death. An especially debilitating heart disease is congestive heart failure. Among the possible therapies, heart transplantation and mechanical circulatory assistance are the main treatments for its severe form at a more advanced stage. The development of biomaterials for ventricular assist devices is still being carried out. Although polished titanium is currently employed in several devices, its performance could be improved by enhancing the bioactivity of its surface.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Aiming to improve the titanium without using coatings that can be detached, this work presents the formation of laser-induced periodic surface structures with a topology suitable for cell adhesion and neointimal tissue formation. The surface was modified by femtosecond laser ablation and cell adhesion was evaluated\n                    <jats:italic>in vitro<\/jats:italic>\n                    by using fibroblast cells.\n                    <jats:italic>Results<\/jats:italic>\n                    . The results indicate the formation of the desired topology, since the cells showed the appropriate adhesion compared to the control group. Scanning electron microscopy showed several positive characteristics in the cells shape and their surface distribution. The\n                    <jats:italic>in vitro<\/jats:italic>\n                    results obtained with different topologies point that the proposed LIPSS would provide enhanced cell adhesion and proliferation.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . The laser processes studied can create new interactions in biomaterials already known and improve the performance of biomaterials for use in ventricular assist devices.\n                  <\/jats:p>","DOI":"10.34133\/2022\/9782562","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T19:45:10Z","timestamp":1664826310000},"source":"Crossref","is-referenced-by-count":2,"title":["Laser-Treated Surfaces for VADs: From Inert Titanium to Potential Biofunctional Materials"],"prefix":"10.34133","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-9052","authenticated-orcid":false,"given":"Eduardo","family":"Bock","sequence":"first","affiliation":[{"name":"Laboratory of Bioengineering and Biomaterials, Federal Institute of Technology in Sao Paulo (IFSP), Sao PauloBrazil"},{"name":"Center of Engineering in Circulatory Assistance, Institute Dante Pazzanese of Cardiology (IDPC), Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9221-9493","authenticated-orcid":false,"given":"Wilhelm","family":"Pfleging","sequence":"additional","affiliation":[{"name":"Institute for Applied Materials-Applied Materials Physics, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayane","family":"Tada","sequence":"additional","affiliation":[{"name":"Federal University of Sao Paulo (UNIFESP), Sao Jose dos Campos, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4274-8506","authenticated-orcid":false,"given":"Erenilda","family":"Macedo","sequence":"additional","affiliation":[{"name":"Federal University of Sao Paulo (UNIFESP), Sao Jose dos Campos, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia","family":"Premazzi","sequence":"additional","affiliation":[{"name":"Laboratory of Bioengineering and Biomaterials, Federal Institute of Technology in Sao Paulo (IFSP), Sao PauloBrazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"S\u00e1","sequence":"additional","affiliation":[{"name":"Center of Engineering in Circulatory Assistance, Institute Dante Pazzanese of Cardiology (IDPC), Sao Paulo, Brazil"},{"name":"National Institute for Space Research (INPE), Sao Jose dos Campos, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Solheid","sequence":"additional","affiliation":[{"name":"Institute for Applied Materials-Applied Materials Physics, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heino","family":"Besser","sequence":"additional","affiliation":[{"name":"Institute for Applied Materials-Applied Materials Physics, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron","family":"Andrade","sequence":"additional","affiliation":[{"name":"Center of Engineering in Circulatory Assistance, Institute Dante Pazzanese of Cardiology (IDPC), Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"issue":"11","key":"e_1_3_3_1_2","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/aor.12228","article-title":"Study of a centrifugal blood pump in a mock loop system","volume":"37","author":"Uebelhart B.","year":"2013","unstructured":"B.Uebelhart, B. 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