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It can be placed closer to the sample for providing angle-varied illumination with higher optical flux and smaller angular increment. With the freeform illuminators, we develop a calibration process using a low-cost Raspberry-Pi image sensor coated with a monolayer of blood cells. By tracking the positional shift of the blood-cell diffraction patterns at 2 distinct regions of the coded sensor, we can infer the 3D positions of the light source elements in a way similar to the stereo vision reconstruction approach. To demonstrate the applications for computational microscopy, we validate the freeform illuminators for Fourier ptychographic microscopy, 3D tomographic imaging, and on-chip microscopy. We also present a longitudinal study by tracking the growth of live bacterial cultures over a large field of view. The reported freeform illuminators and the related calibration process offer flexibilities and extended scope for imaging innovations in computational microscopy.<\/jats:p>","DOI":"10.34133\/icomputing.0015","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T14:50:07Z","timestamp":1672930207000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Freeform Illuminator for Computational Microscopy"],"prefix":"10.34133","volume":"2","author":[{"given":"Pengming","family":"Song","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA."},{"name":"Advanced Optoelectronic Imaging and Device Laboratory, Hangzhou Institute of Technology, Xidian University, Hangzhou 311200, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Electronic Science and Engineering, Nanjing University, Nanjing 210023, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.micron.2017.11.006","article-title":"Oblique illumination in microscopy: A quantitative evaluation","volume":"105","author":"Sanchez C","year":"2018","unstructured":"Sanchez C, Crist\u00f3bal G, Bueno G, Blanco S, Borrego-Ramos M, Olenici A, Pedraza A, Ruiz-Santaquiteria J. 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