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Exogenous delivery of hydrogen sulfide (H\n            <jats:sub>2<\/jats:sub>\n            S) to the injured myocardium can be an effective strategy for treating MIRI due to the multiple physiologic functions of H\n            <jats:sub>2<\/jats:sub>\n            S, including anti-inflammatory, anti-apoptotic, and mitochondrial protective effects. Here, to realize the precise delivery and release of H\n            <jats:sub>2<\/jats:sub>\n            S, we proposed the targeted H\n            <jats:sub>2<\/jats:sub>\n            S-mediated gas therapy with pH-sensitive release property mediated by platelet membranes (PMs). In this study, a biomimetic functional poly(lactic-co-ethanolic acid) nanoparticle (RAPA\/JK-1-PLGA@PM) was fabricated by loading rapamycin (RAPA; mTOR inhibitor) and JK-1 (H\n            <jats:sub>2<\/jats:sub>\n            S donor) and then coated with PM. In\u00a0vitro observations were conducted including pharmaceutical evaluation, H\n            <jats:sub>2<\/jats:sub>\n            S release behaviors, hemolysis analysis, serum stability, cellular uptake, cytotoxicity, inhibition of myocardial apoptosis, and anti-inflammation. In\u00a0vivo examinations were performed including targeting ability, restoration of cardiac function, inhibition of pathological remodeling, and anti-inflammation. RAPA\/JK-1-PLGA@PM was successfully prepared with good size distribution and stability. Utilizing the natural infarct-homing ability of PM, RAPA\/JK-1-PLGA@PM could be effectively targeted to the damaged myocardium. RAPA\/JK-1-PLGA@PM continuously released H\n            <jats:sub>2<\/jats:sub>\n            S triggered by inflammatory microenvironment, which could inhibit cardiomyocyte apoptosis, realize the transition of pro-inflammation, and alleviate myocardial injury demonstrated in hypoxia\/reoxygenation myocardial cell in\u00a0vitro. Precise delivery and release of H\n            <jats:sub>2<\/jats:sub>\n            S attenuated inflammatory response and cardiac damage, promoted cardiac repair, and ameliorated cardiac function proven in MIRI mouse model in\u00a0vivo. This research outlined the novel nanoplatform that combined immunosuppressant agents and H\n            <jats:sub>2<\/jats:sub>\n            S donor with the pH-sensitive release property, offering a promising therapeutic for MIRI treatment that leveraged the synergistic effects of gas therapy.\n          <\/jats:p>","DOI":"10.34133\/bmr.0061","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T16:21:04Z","timestamp":1720628464000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":17,"title":["Targeted H\n            <sub>2<\/sub>\n            S-Mediated Gas Therapy with pH-Sensitive Release Property for Myocardial Ischemia\u2013Reperfusion Injury by Platelet Membrane"],"prefix":"10.34133","volume":"28","author":[{"given":"Lin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, \rThe Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China."},{"name":"Department of Pharmacy, \rShantou University Medical College, Shantou 515041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucen","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \rShantou University Medical College, Shantou 515041, China."},{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \rThe Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China."},{"name":"Department of Pharmacy, \rShantou University Medical College, Shantou 515041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingrong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \rThe Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China."},{"name":"Department of Pharmacy, \rShantou University Medical College, Shantou 515041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \rThe Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China."},{"name":"Department of Pharmacy, \rShantou University Medical College, Shantou 515041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \rThe Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China."},{"name":"Department of Pharmacy, \rShantou University Medical College, Shantou 515041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaofeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \rThe Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \rThe Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Degong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \rShantou University Medical College, Shantou 515041, China."},{"name":"Department of Pharmacy, Department of Dermatology, \rThe First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \rThe Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China."},{"name":"Department of Pharmacy, \rShantou University Medical College, Shantou 515041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"issue":"15","key":"e_1_3_4_2_2","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202105408","article-title":"An injectable dual-function hydrogel protects against myocardial ischemia\/reperfusion injury by modulating ROS\/NO disequilibrium","volume":"9","author":"Hao T","year":"2022","unstructured":"Hao T, Qian M, Zhang Y, Liu Q, Midgley AC, Liu Y, Che Y, Hou J, Zhao Q. 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