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With continuous advances in diagnostic technology and treatment approaches, the survival rates of some cancers have increased. Nevertheless, due to the complexity of the mechanisms underlying tumors, cancer remains a serious public health issue that threatens the health of the population globally. Manganese (Mn) is an essential trace element for the human body. Its regulatory role in tumor biology has received much attention in recent years. Developments in nanotechnology have led to the emergence of Mn-based nanoparticles that have great potential for use in the diagnosis and treatment of cancers. Mn-based nanomaterials can be integrated with conventional techniques, including chemotherapy, radiation therapy, and gene therapy, to augment their therapeutic effectiveness. Further, Mn-based nanomaterials can play a synergistic role in emerging treatment strategies for tumors, such as immunotherapy, photothermal and photodynamic therapy, electromagnetic hyperthermia, sonodynamic therapy, chemodynamic therapy, and intervention therapy. Moreover, Mn-based nanomaterials can enhance both the precision of tumor diagnostics and the capability for combined diagnosis and treatment. This article examines the roles and associated mechanisms of Mn in the field of physiology and tumor biology, with a focus on the application prospects of Mn-based nanomaterials in tumor diagnosis and treatment.<\/jats:p>","DOI":"10.34133\/bmr.0158","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T09:55:39Z","timestamp":1739872539000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":34,"title":["Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy"],"prefix":"10.34133","volume":"29","author":[{"given":"Xiaowen","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Forensic Medicine, \rChina Medical University, Shenyang 110122, China."},{"name":"Liaoning Province Key Laboratory of Forensic Bio-evidence Sciences, Shenyang 110122, China."},{"name":"China Medical University Center of Forensic Investigation, Shenyang 110122, China."},{"name":"First Department of Clinical Medicine, \rChina Medical University, Shenyang 110122, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, \rthe First Hospital of China Medical University, Shenyang 110001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Forensic Medicine, \rChina Medical University, Shenyang 110122, China."},{"name":"Liaoning Province Key Laboratory of Forensic Bio-evidence Sciences, Shenyang 110122, China."},{"name":"China Medical University Center of Forensic Investigation, Shenyang 110122, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingrui","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Forensic Medicine, \rChina Medical University, Shenyang 110122, China."},{"name":"Liaoning Province Key Laboratory of Forensic Bio-evidence Sciences, Shenyang 110122, China."},{"name":"China Medical University Center of Forensic Investigation, Shenyang 110122, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zikai","family":"Jin","sequence":"additional","affiliation":[{"name":"First Department of Clinical Medicine, \rChina Medical University, Shenyang 110122, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ge","sequence":"additional","affiliation":[{"name":"School of Pharmacy, \rQueen\u2019s University Belfast, Belfast BT9 7BL, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Forensic Pathology, School of Forensic Medicine, \rChina Medical University, Shenyang 110122, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxin","family":"An","sequence":"additional","affiliation":[{"name":"Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, \rChina Medical University, Shenyang 110122, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3569-4008","authenticated-orcid":true,"given":"Liang","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Forensic Medicine, \rChina Medical University, Shenyang 110122, China."},{"name":"Liaoning Province Key Laboratory of Forensic Bio-evidence Sciences, Shenyang 110122, China."},{"name":"China Medical University Center of Forensic Investigation, Shenyang 110122, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2018.11.026"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307752"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S376216"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45990"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01096-0"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202101171"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00936-y"},{"key":"e_1_3_4_12_2","first-page":"135","article-title":"Nanomaterials-based photosensitizers and delivery systems for photodynamic cancer therapy","author":"Yu X-T","year":"2022","unstructured":"Yu X-T, Sui S-Y, He Y-X, Yu C-H, Peng Q. 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