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Although antibacterial phytochemicals are a promising approach for long-term treatment of resistant bacteria, their low antibacterial activity and poor solubility hinder their practical applications. Here, the natural antibacterial compound sanguinarine (SG) together with gallic acid\u2013ferrous coordination nanoparticles (GA-Fe(II) NPs) was encapsulated in a near-infrared (NIR)-activated thermo-responsive liposome. By virtue of the photothermal effect of GA-Fe(II) NPs, the nanoplatform released SG on demand upon NIR irradiation. Additionally, the heat can boost the Fenton reaction triggered by GA-Fe(II) NPs to generate hydroxyl radicals and perform sterilization. By coupling with photothermal therapy, chemodynamic therapy, and SG-based pharmacotherapy, the platform showed enhanced antibacterial efficiency and an antibiofilm effect toward methicillin-resistant\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            and reduced the risk of developing new bacterial resistance. This antibacterial system displayed excellent antibacterial activity in a methicillin-resistant\n            <jats:italic>S. aureus<\/jats:italic>\n            -caused skin abscess, demonstrating its potential clinical application. Moreover, transcription analysis clarified that the platform achieved a synergistic antibacterial effect by attacking the cell membrane, inducing energy metabolism disorder, inhibiting nucleic acid synthesis, etc. The developed NIR-controlled phytochemical-loaded platform offers new possibilities for killing antibiotic-resistant bacteria and avoiding bacterial resistance, making it contributory in the fields of anti-infective therapy and precision medicine.\n          <\/jats:p>","DOI":"10.34133\/bmr.0159","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T16:44:08Z","timestamp":1740761048000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Phytochemical-Loaded Thermo-responsive Liposome for Synergistic Treatment of Methicillin-Resistant\n            <i>Staphylococcus aureus<\/i>\n            Infection"],"prefix":"10.34133","volume":"29","author":[{"given":"Sidi","family":"Zheng","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, \rNortheast Agricultural University, Harbin 150030, PR China."},{"name":"Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinshu","family":"Zou","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, \rNortheast Agricultural University, Harbin 150030, PR China."},{"name":"Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, \rNortheast Agricultural University, Harbin 150030, PR China."},{"name":"Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilong","family":"Cui","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, \rNortheast Agricultural University, Harbin 150030, PR China."},{"name":"Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, \rNortheast Agricultural University, Harbin 150030, PR China."},{"name":"Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Harbin 150030, PR China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiubo","family":"Li","sequence":"additional","affiliation":[{"name":"Feed Research Institute, \rChinese Academy of Agricultural Sciences, Beijing 100081, PR 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