{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:15:57Z","timestamp":1787030157962,"version":"build-2736575974"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2025-25441283"],"award-info":[{"award-number":["RS-2025-25441283"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2024-00334037"],"award-info":[{"award-number":["RS-2024-00334037"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>Inflammatory skin diseases are chronic conditions characterized by persistent inflammation and disrupted skin barriers, necessitating sustained drug delivery. This study presents a long-acting hybrid dissolving microneedle (DMN) patch incorporating hyaluronic acid (HA)-based microparticle depots (TA@MDepots) for intradermal delivery of triamcinolone acetonide (TA). HA is modified to HA acetate to enhance compatibility with hydrophobic TA, enabling efficient microdepot formulation. These TA@MDepots are integrated into the DMN tip layer using mold-casting, resulting in patches with strong mechanical properties and rapid tip dissolution (&lt;3 min) upon application. In\u00a0vitro and ex\u00a0vivo studies demonstrate effective skin penetration, sustained dermal retention, and prolonged TA release. The hybrid patch shows excellent cytocompatibility and significantly reduces tumor necrosis factor-alpha and interleukin-6 levels in activated macrophages. In\u00a0vivo, the patch outperforms commercial TA ointment in a murine ulcer model by accelerating wound closure, reducing epidermal thickening, and lowering inflammatory cytokine expression, despite a lower TA dosage and fewer applications. Histological analyses confirm skin structure restoration and immune modulation, while systemic toxicity assessments show no adverse effects. This hybrid DMN platform offers a minimally invasive, biocompatible, and patient-friendly strategy for prolonged corticosteroid delivery in chronic inflammatory skin diseases and represents a promising alternative to conventional topical or injectable therapies.<\/jats:p>","DOI":"10.34133\/bmr.0303","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T21:41:28Z","timestamp":1765230088000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Hybrid Dissolving Microneedles Incorporating Hyaluronic Acid Microdepots for Pain-free and Long-acting Corticosteroid Therapy"],"prefix":"10.34133","volume":"30","author":[{"given":"Jae Hwan","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medical Science, \rSoonchunhyang University, Asan 31538, Republic of 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