{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:16:17Z","timestamp":1778141777397,"version":"3.51.4"},"reference-count":50,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2024-00423107"],"award-info":[{"award-number":["RS-2024-00423107"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2020R1A5A8018367"],"award-info":[{"award-number":["2020R1A5A8018367"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2022-NR067329"],"award-info":[{"award-number":["RS-2022-NR067329"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","award":["20012378"],"award-info":[{"award-number":["20012378"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2025-RISE-05-011"],"award-info":[{"award-number":["2025-RISE-05-011"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs","doi-asserted-by":"crossref","award":["RS-2024-00397026"],"award-info":[{"award-number":["RS-2024-00397026"]}],"id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2025-19252970"],"award-info":[{"award-number":["RS-2025-19252970"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    Hydrogel-based tissue adhesives hold promise for diverse biomedical applications, yet achieving strong, durable adhesion to wet, dynamic biological surfaces remains challenging. The catechol-containing amino acid 3,4-dihydroxy-\n                    <jats:sc>l<\/jats:sc>\n                    -phenylalanine (DOPA) is a crucial functional motif in mussel-inspired adhesives and has been extensively investigated for incorporation into various biomaterials. However, conventional approaches of DOPA incorporation and subsequent crosslinking have shown limited potential for clinical translation. We developed a bioinspired strategy involving pH-controlled enzymatic conversion of tyrosine residues in porcine gelatin into DOPA. The resulting catechol-functionalized gelatin was blended with native tyrosine-rich gelatin to form a hybrid adhesive hydrogel, termed DOPA\u2013tyrosine gelatin (DTG) bioglue. DTG was designed to achieve (a) rapid visible-light-driven ruthenium-based crosslinking for structural integrity and (b) enhanced interfacial adhesion via DOPA-mediated interactions with tissue surface. Its shear-thinning and fast-curing properties enable its use as a bioink for both extrusion-based and digital-light-processing 3-dimensional bioprinting. We demonstrated the DTG-assisted tissue\u2013tissue integration for large-area construct assembly, addressing current volumetric fabrication limitations in microextrusion bioprinting. Moreover, it demonstrated superior hemostatic performance in rat liver and vascular injury models. Collectively, DTG bioglue is a promising candidate for next-generation adhesive biomaterial for regenerative medicine and surgical applications.\n                  <\/jats:p>","DOI":"10.34133\/bmr.0360","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:34:17Z","timestamp":1775064857000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Visible-Light-Curable Catechol-Reinforced Gelatin Bioglue for Rapid Hemostasis and Engineered Tissue Assembly"],"prefix":"10.34133","volume":"30","author":[{"given":"Ashfaq","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Convergence Biosystems Engineering, College of Agriculture and Life Sciences, \rChonnam National University, Gwangju, Republic of Korea."},{"name":"Interdisciplinary Program in IT-Bio Convergence System, \rChonnam National University, Gwangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Convergence Biosystems Engineering, College of Agriculture and Life Sciences, \rChonnam National University, Gwangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaylord M.","family":"Pioquinto","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, \rChonnam National University, Gwangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, \rChonnam National University, Gwangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, \rChonnam National University Hospital, Gwangju, Republic of Korea."},{"name":"Medical Research Center, \rChonnam National University Medical School, Hwasun, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessie S.","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, \rKorea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong-Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Advanced Bio and Healthcare Materials Research Division, \rKorea Institute of Materials Science (KIMS), Changwon, Republic of Korea."},{"name":"Advanced Materials Engineering, \rKorea National University of Science and Technology (UST), Daejeon, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3042-8564","authenticated-orcid":true,"given":"Hee-Gyeong","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Convergence Biosystems Engineering, College of Agriculture and Life Sciences, \rChonnam National University, Gwangju, Republic of Korea."},{"name":"Interdisciplinary Program in IT-Bio Convergence System, \rChonnam National University, Gwangju, Republic of Korea."},{"name":"Institute for Biomedical Science, \rChonnam National University Hospital Hwasun, Hwasun, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01677"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah6362"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1710-5"},{"issue":"21","key":"e_1_3_4_5_2","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300192","article-title":"ECM-like adhesive hydrogel for the regeneration of large corneal stromal defects","volume":"12","author":"Wang F","year":"2023","unstructured":"Wang F, Zhang W, Qiao Y, Shi D, Hu L, Cheng J, Wu J, Zhao L, Li D, Shi W, et al. 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