{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:41:57Z","timestamp":1782366117142,"version":"3.54.5"},"reference-count":49,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["23QA1412000"],"award-info":[{"award-number":["23QA1412000"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Natural Science Foundation","doi-asserted-by":"crossref","award":["25ZR1401268"],"award-info":[{"award-number":["25ZR1401268"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    Inflammatory bowel disease (IBD) remains a therapeutic challenge due to its ongoing inflammation and the limited availability of effective local therapies. This study developed a biomimetic nanocomposite, layered double hydroxide-molybdenum disulfide (LDH-MoS\n                    <jats:sub>2<\/jats:sub>\n                    [LM]) nanosheets encapsulated with bovine serum albumin (abbreviated as LM@BSA), with the aim of enhancing reactive oxygen species scavenging efficiency and improving colloidal stability while favoring lesion-associated localization and local retention in inflamed colonic tissue. In a dextran sulfate sodium-induced colitis mouse model, oral administration of LM@BSA nanocomposite significantly improved disease outcomes, as shown by reduced colon shortening, less body weight loss, and decreased levels of pro-inflammatory cytokines. Mechanistic analysis demonstrated that the LM@BSA nanocomposite inhibits ferroptosis by protecting mitochondrial structure and increasing glutathione peroxidase 4 expression. Transcriptomic data showed that the LM@BSA nanocomposite helps restore intestinal balance by down-regulating the phosphoinositide 3-kinase\u2013protein kinase B signaling pathway, regulating extracellular matrix remodeling, and supporting immune pathway stability. Moreover, the LM@BSA nanocomposite corrected gut microbiota dysbiosis by increasing the abundance of beneficial\n                    <jats:italic toggle=\"yes\">Bacteroidales<\/jats:italic>\n                    and reducing pro-inflammatory\n                    <jats:italic toggle=\"yes\">Desulfovibrionales<\/jats:italic>\n                    . These findings suggest that the LM@BSA nanocomposite offers a promising and comprehensive multifaceted nanotherapeutic approach for IBD by modulating oxidative stress, ferroptosis, immune dysregulation, and gut microbiota imbalance.\n                  <\/jats:p>","DOI":"10.34133\/bmr.0369","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:57:34Z","timestamp":1777510654000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["Biomimetic Layered Double Hydroxide-Molybdenum Disulfide Encapsulated with Bovine Serum Albumin: A Multifaceted Nanotherapy for Inflammatory Bowel Disease"],"prefix":"10.34133","volume":"30","author":[{"given":"Yijie","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital; National Key Laboratory of Immunity and Inflammation, \rNaval Medical University, Shanghai 200433, P. 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