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Recently, nanovesicles derived from tonsil mesenchymal stem cells (TMSC-NVs) were investigated for their potential to reverse cellular senescence. However, the molecular mechanisms through which TMSC-NVs prevent senescence remain unclear. In the present study, we focused on Cluster of Differentiation 146 (CD146), a surface marker used to identify specific MSC subgroups and examined the anti-senescence effects of CD146-positive TMSC-NVs (CD146\n                    <jats:sup>+<\/jats:sup>\n                    TMSC-NVs). To evaluate the antisenescence effects of the CD146\n                    <jats:sup>+<\/jats:sup>\n                    TMSC-NVs, passage-associated cellular senescence in\u00a0vitro human dermal fibroblast model, ultraviolet-B-induced photoaging ex\u00a0vivo model, and intrinsic aging in\u00a0vivo mice model were assessed. Microarray analysis, immunofluorescence staining, and miRNA profiling demonstrated the anti-senescence mechanism of CD146\n                    <jats:sup>+<\/jats:sup>\n                    TMSC-NVs through modulation of the p53 pathway, thereby effectively suppressing cellular senescence and matrix metalloproteinase activity and improving extracellular matrix remodeling. These results indicate the anti-senescence effects of CD146\n                    <jats:sup>+<\/jats:sup>\n                    TMSC-NVs for therapeutic approach.\n                  <\/jats:p>","DOI":"10.34133\/bmr.0371","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:30:07Z","timestamp":1778002207000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Anti-senescence Effects of Nanovesicles Derived from Cluster of Differentiation-146-Positive Tonsil Mesenchymal Stem Cells via Modulation of the Tumor Protein 53 Pathway"],"prefix":"10.34133","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5530-2161","authenticated-orcid":false,"given":"Dohyun","family":"Kim","sequence":"first","affiliation":[{"name":"PLCOskin Co., Ltd","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Bae","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Medicine, \rYonsei University Graduate School, Seoul 07322, Republic of Korea."},{"name":"Department of Plastic and Reconstructive Surgery, Dankook University Hospital, \rDankook University College of Medicine, Cheonan, Chungnam 31116, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu-Sik","family":"Shim","sequence":"additional","affiliation":[{"name":"PLCOskin Co., Ltd","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Su","family":"Park","sequence":"additional","affiliation":[{"name":"PLCOskin Co., Ltd","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Kee","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Systems Biotechnology, \rChung-Ang University, Anseong, Gyeonggi 17546, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), \rDankook University, Cheonan, Chungnam 31116, Republic of Korea."},{"name":"Department of Biomaterials Science, College of Dentistry, \rDankook University, Cheonan, Chungnam 31116, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Hui","family":"Park","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), \rDankook University, Cheonan, Chungnam 31116, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang-Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration Engineering (ITREN), \rDankook University, Cheonan, Chungnam 31116, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Research Institute of Women\u2019s Health, Brain Korea 21 Project, \rSookmyung Women\u2019s University, Seoul 04310, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinseo","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Biological Science, \rSookmyung Women\u2019s University, Seoul 04310, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Bok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Research Institute of Women\u2019s Health, Brain Korea 21 Project, \rSookmyung Women\u2019s University, Seoul 04310, Republic of Korea."},{"name":"Department of Biological Science, \rSookmyung Women\u2019s University, Seoul 04310, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6638-4110","authenticated-orcid":true,"given":"Wooyeol","family":"Baek","sequence":"additional","affiliation":[{"name":"PLCOskin Co., Ltd","place":["Republic of Korea"]},{"name":"Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Severance Hospital, \rYonsei University College of Medicine, Seoul 07322, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"issue":"1","key":"e_1_3_4_2_2","first-page":"29","article-title":"Global aging and intergenerational equity","volume":"1","author":"Wisensale SK","year":"2003","unstructured":"Wisensale SK. 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