{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:18:20Z","timestamp":1788250700342,"version":"build-2803163510"},"reference-count":46,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"name":"the Basic and Applied Basic Research Fund-Natural Science Foundation of Guangdong Province","award":["No. 2023A1515011483"],"award-info":[{"award-number":["No. 2023A1515011483"]}]},{"name":"the Innovation Team Project-Scientific Research Project of Ordinary Universities in Guangdong Province, China","award":["No. 2023KCXTD019"],"award-info":[{"award-number":["No. 2023KCXTD019"]}]},{"name":"the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences","award":["CI2023D003"],"award-info":[{"award-number":["CI2023D003"]}]},{"name":"A Comprehensive Evaluation Standard and Early Diagnosis Model for Abnormal Subhealth Status of Glucose and Lipid Metabolism","award":["No. 2023YFC3606202"],"award-info":[{"award-number":["No. 2023YFC3606202"]}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    Balancing short-term antibacterial needs with long-term anti-inflammatory effects remains a major challenge in wound healing. Multifunctional bioactive materials capable of both efficient antibacterial action and inflammation modulation represent a promising solution. However, the majority of traditional antibacterial biomaterials possess only a single antibacterial effect, and their synthesis and preparation are intricate, which might restrict their clinical transformation. Chlorogenic acid is a natural compound endowed with anti-inflammatory properties. However, it is beset by certain inherent drawbacks, including poor water solubility and limited bioavailability. To overcome these difficulties, we have fabricated multifunctional nanoparticles (chlorogenic acid\u2013iron nanoparticles, CA-Fe NPs) through the co-assembly of chlorogenic acid and iron ions in a straightforward manner. We found that CA-Fe NPs exhibit excellent photothermal conversion performance in\u00a0vitro. Upon near-infrared (NIR) irradiation, they exhibit potent broad-spectrum antimicrobial activity against\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    . The CA-Fe NPs markedly reduced H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    -induced reactive oxygen species levels and apoptosis in epithelial cells and suppressed lipopolysaccharide-induced M1 macrophage polarization in RAW 264.7 cells. Transmission electron microscopy results revealed enhanced bacterial membrane disruption by CA-Fe NPs under NIR irradiation, causing pronounced protein leakage. Transcriptomic analysis indicates that CA-Fe NPs combined with NIR disrupt the tricarboxylic acid cycle, cell-wall organization, and other metabolic processes. In\u00a0vivo, within a methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    -infected skin wound model, CA-Fe NPs maintained photothermal efficacy, effectively reduced serum levels of interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha, and accelerated wound healing. These findings suggest that CA-Fe NPs are multifunctional materials with broad-spectrum bactericidal ability, antioxidant, anti-inflammatory, and wound-healing-promotion properties. These nanoparticles possess promising prospects for biomedical applications.\n                  <\/jats:p>","DOI":"10.34133\/bmr.0387","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:48:07Z","timestamp":1781801287000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional Metal Polyphenol Nanoparticles Based on Photothermal Therapy for Bacterial Eradication and Wound Healing"],"prefix":"10.34133","volume":"30","author":[{"given":"Haitao","family":"Yuan","sequence":"first","affiliation":[{"name":"Center for Drug Research and Development, Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations, \rGuangdong Pharmaceutical University, Guangzhou 510006, P.R. China."},{"name":"Department of Clinical Laboratory, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, \rShenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, \rShenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, P.R. China."},{"name":"Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, \rSouthern Medical University, Guangzhou 510515, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zou","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, \rSouthern Medical University, Guangzhou 510515, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, \rShenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunmeng","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, \rShenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhe","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Drug Research and Development, Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations, \rGuangdong Pharmaceutical University, Guangzhou 510006, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, \rShenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, \rShenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, \rShenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyue","family":"He","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, \rSouthern Medical University, Guangzhou 510515, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Centing","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Drug Research and Development, Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations, \rGuangdong Pharmaceutical University, Guangzhou 510006, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, \rShenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Clinical Medicine, Medical School, \rKunming University of Science and Technology, Kunming, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, \rShenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, P.R. 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.7748\/ns.2022.e11889"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-021-00932-7"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.glmedi.2024.100081"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30471-7"},{"key":"e_1_3_4_7_2","unstructured":"O\u2019Neill J. Tackling drug-resistant infections globally: Final report and recommendations. 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