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To address this complicated pathological condition, a porphyrin-doped cobalt-magnesium bimetallic quercetin-based sonosensitive nanozyme (CoMg-Que) was engineered to integrate antibacterial therapy, redox modulation, and tissue regenerative functions within a single platform. Upon ultrasound (US) irradiation, CoMg-Que was activated and efficiently generated reactive oxygen species (ROS) for sonodynamic antibacterial treatment. Following termination of US stimulation, its inherent superoxide dismutase- and catalase-like activities further removed excessive ROS, thereby relieving inflammatory responses and re-establishing redox homeostasis. In\u00a0vitro experiments demonstrated that CoMg-Que effectively eliminated methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (MRSA) and exhibited favorable immunomodulatory, pro-angiogenic, and osteogenic properties. In an MRSA-infected rat calvarial defect model, CoMg-Que achieved an antibacterial efficiency of 95.24% and markedly enhanced bone regeneration, with the bone volume fraction reaching 26.76%. These findings indicate that CoMg-Que may serve as a promising multifunctional platform for infectious bone defect treatment through coordinated antibacterial, immunoregulatory, and regenerative activities.\n                  <\/jats:p>","DOI":"10.34133\/bmr.0396","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:19:14Z","timestamp":1782857954000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["Sonodynamic CoMg-Quercetin Nanozyme for Antibacterial Therapy and Multifunctional Bone Regeneration in Infectious Bone Defects"],"prefix":"10.34133","volume":"30","author":[{"given":"Yurong","family":"Xu","sequence":"first","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology","place":["China"]},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Yan","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology","place":["China"]},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology","place":["China"]},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenying","family":"Cui","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology","place":["China"]},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology","place":["China"]},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology","place":["China"]},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuping","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology","place":["China"]},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9410-733X","authenticated-orcid":true,"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology","place":["China"]},{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03295-0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123588"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300303"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c12343"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.160962"},{"issue":"1","key":"e_1_3_4_7_2","first-page":"144","article-title":"Beyond antibiotics: Photo\/sonodynamic approaches for bacterial theranostics","volume":"12","author":"Pang X","year":"2020","unstructured":"Pang X, Li D, Zhu J, Cheng J, Liu G. 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