{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T08:45:50Z","timestamp":1785746750307,"version":"3.56.0"},"reference-count":49,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82574589"],"award-info":[{"award-number":["82574589"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Administration of Traditional Chinese Medicine Young Qihuang Scholar Project","award":["2023KJ136"],"award-info":[{"award-number":["2023KJ136"]}]},{"name":"Science & Technology Development Fund of Tianjin Education Commission for Higher Education","award":["2024ZD003"],"award-info":[{"award-number":["2024ZD003"]}]},{"name":"The Science & Technology Development Fund of Tianjin Education Commission for Higher Education","award":["2025ZD045"],"award-info":[{"award-number":["2025ZD045"]}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    Triple-negative breast cancer (TNBC) presents formidable treatment barriers due to dysfunctional vasculature and an immunosuppressive microenvironment. To address these challenges, we engineered a bioinspired near-infrared (NIR)-responsive copper\u2013polyphenol nanoplatform, SCP, to implement a NIR-triggered \u201cbridge-and-attack\u201d therapeutic strategy. This nanoassembly was constructed through the coordination of salvianolic acid B (SAB) with copper ions and further stabilized by a polydopamine (PDA) shell. Upon NIR irradiation, SAB and Cu\n                    <jats:sup>2+<\/jats:sup>\n                    were co-released from SCP, enabling simultaneous vascular remodeling and tumor cell killing. The released SAB promoted vascular normalization, increasing pericyte coverage to 51.6% and alleviating tumor hypoxia, thereby facilitating intratumoral penetration and immune-cell infiltration. Meanwhile, released Cu\n                    <jats:sup>2+<\/jats:sup>\n                    , together with PDA-mediated photothermal activation, induced cuproptosis and immunogenic cell death (ICD). This combined remodeling of the tumor microenvironment enhanced CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration and achieved a tumor inhibition rate of 88.5% in 4T1 tumor-bearing mice with favorable systemic biosafety. Overall, this interfacial nanomaterial design integrates vascular normalization, photothermal-enhanced cuproptosis, and immunotherapy, providing a promising materials-based strategy for TNBC treatment.\n                  <\/jats:p>","DOI":"10.34133\/bmr.0398","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:25:03Z","timestamp":1784157903000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Near-Infrared-Triggered \u201cBridge-and-Attack\u201d Strategy via a Bioinspired Copper\u2013Polyphenol Nanoarchitectonics Platform for Vascular Normalization-Enhanced Cuproptosis-Immunotherapy of Triple-Negative Breast Cancer"],"prefix":"10.34133","volume":"30","author":[{"given":"Xinru","family":"Shen","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, \rTianjin University of Traditional Chinese Medicine, Tianjin 301617, China."},{"name":"State Key Laboratory 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