{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:01:39Z","timestamp":1790078499152,"version":"4.0.1"},"reference-count":34,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"name":"the Guangdong Basic and Applied Basic Research Foundation","award":["2023A1515010620 and 2024A1515012478"],"award-info":[{"award-number":["2023A1515010620 and 2024A1515012478"]}]},{"name":"Zhuhai basic and applied basic research project","award":["ZH22017003210009PWC"],"award-info":[{"award-number":["ZH22017003210009PWC"]}]},{"name":"Zhuhai Science and Technology Bureau","award":["2420004000007"],"award-info":[{"award-number":["2420004000007"]}]},{"name":"Guangdong Provincial Bureau of Traditional Chinese Medicine","award":["20251345"],"award-info":[{"award-number":["20251345"]}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    Ferroptosis, a regulated cell death pathway driven by iron-dependent lipid peroxidation, has emerged as a promising strategy for cancer therapy. Nevertheless, the direct delivery of iron can lead to systemic toxicity. In this study, a nonferrous ferroptosis-like strategy employing 2D Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    MXene nanosheets was developed. The Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    nanozyme has been shown to possess peroxidase- and catalase-like activities, capable of decomposing H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    into cytotoxic\u00b7OH and O\n                    <jats:sub>2<\/jats:sub>\n                    , respectively. When exposed to near-infrared II laser irradiation, Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    induced a localized increase in temperature and amplified reactive oxygen species production, resulting in a synergistic effect that led to mitochondrial damage and glutathione peroxidase 4 inactivation. In\u00a0vivo studies demonstrated tumor suppression in triple-negative breast cancer (TNBC) models, accompanied by M1 macrophage polarization and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell activation. This work provides a novel paradigm for nanocatalytic ferroptosis therapy, combining enzymatic activity, photothermal effects, and immunomodulation to overcome TNBC resistance.\n                  <\/jats:p>","DOI":"10.34133\/bmr.0400","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:06:17Z","timestamp":1787861177000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["2D Titanium-Based Nanozyme Induced a Ferroptosis-like Strategy for Triple-Negative Breast Cancer Therapeutics"],"prefix":"10.34133","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8004-6444","authenticated-orcid":false,"given":"Hailing","family":"Yu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Engineering Research Center of Molecular Imaging, Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, \rSun Yat-sen University, No. 52 of Meihuadong Road, Xiangzhou District, Zhuhai, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songying","family":"Pi","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Fifth Affiliated Hospital, \rSun Yat-sen University, No. 52 of Meihuadong Road, Xiangzhou District, Zhuhai, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zebo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Zhuhai Hospital of Integrated Traditional Chinese & Western Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DongHui","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhuhai Hospital of Integrated Traditional Chinese & Western Medicine","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Fifth Affiliated Hospital, \rSun Yat-sen University, No. 52 of Meihuadong Road, Xiangzhou District, Zhuhai, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feile","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Fifth Affiliated Hospital, \rSun Yat-sen University, No. 52 of Meihuadong Road, Xiangzhou District, Zhuhai, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Engineering Research Center of Molecular Imaging, Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, \rSun Yat-sen University, No. 52 of Meihuadong Road, Xiangzhou District, Zhuhai, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Lan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Engineering Research Center of Molecular Imaging, Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, \rSun Yat-sen University, No. 52 of Meihuadong Road, Xiangzhou District, Zhuhai, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Engineering Research Center of Molecular Imaging, Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, The Fifth Affiliated Hospital, \rSun Yat-sen University, No. 52 of Meihuadong Road, Xiangzhou District, Zhuhai, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, \rHarbin Institute of Technology, No. 92 of Xidazhi Street, Nangang District, Harbin, Heilongjiang, 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