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Herein, we report an injectable dual-dynamic covalent hydrogel fabricated from phenylboronic-acid-functionalized oxidized sodium alginate and gallic-acid-conjugated chitosan. Crosslinked via reversible Schiff base and boronate ester bonds, the hydrogel exhibits excellent injectability, self-healing capability, and structural stability. Under hyperglycemic conditions, competitive glucose binding modulates the boronate ester equilibrium and induces glucose-responsive release of galloyl-containing species. These glucose-responsive release behaviors contribute to the antioxidant, antibacterial, and immunoregulatory activities of the hydrogel. In\u00a0vitro and in\u00a0vivo results demonstrate that the hydrogel promotes macrophage polarization toward the anti-inflammatory M2 phenotype, alleviates inflammatory responses, enhances angiogenesis, and accelerates skin regeneration. Collectively, the phenylboronic-acid-functionalized oxidized sodium alginate and gallic-acid-conjugated chitosan hydrogel represents a multifunctional glucose-responsive biomaterial with considerable potential for diabetic wound therapy.<\/jats:p>","DOI":"10.34133\/bmr.0405","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:51:24Z","timestamp":1785455484000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["A Glucose-Responsive Hydrogel with Multifunctional Properties for Accelerated Diabetic Wound Healing"],"prefix":"10.34133","volume":"30","author":[{"given":"Zhaoguo","family":"Wang","sequence":"first","affiliation":[{"name":"Center of Oral Implantology, Stomatological Hospital, School of Stomatology, \rSouthern Medical University, Guangzhou 510632, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susu","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, \rShanghai Jiao Tong University, Shanghai 200240, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lai","sequence":"additional","affiliation":[{"name":"Center of Oral Implantology, Stomatological Hospital, School of Stomatology, \rSouthern Medical University, Guangzhou 510632, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Oral Implantology, Stomatological Hospital, School of Stomatology, \rSouthern Medical University, Guangzhou 510632, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, \rInner Mongolia Minzu University, Tongliao 028000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulan","family":"Xu","sequence":"additional","affiliation":[{"name":"Center of Oral Implantology, Stomatological Hospital, School of Stomatology, \rSouthern Medical University, Guangzhou 510632, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v16.i3.100329"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/medsci13030087"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2020.103987"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkae084"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301885"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.120228"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126841"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.122832"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.113096"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.131179"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.139151"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-024-00672-3"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rineng.2024.103900"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/C3PY01202F"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.06.016"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.05.047"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1740559"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112609"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.102569"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142108"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26429"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2021.06.013"},{"issue":"8","key":"e_1_3_4_24_2","first-page":"1155","article-title":"Polysaccharide-based injectable self-healing hydrogels with glucose-responsive drug release","volume":"54","author":"Tan WW","year":"2023","unstructured":"Tan WW, Lei SS, Long T, Xu ZL, Li DF, Mu CD, Ge LM. 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