{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:17:59Z","timestamp":1788164279463,"version":"build-2803163510"},"reference-count":49,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00337706"],"award-info":[{"award-number":["RS-2024-00337706"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-02216206"],"award-info":[{"award-number":["RS-2025-02216206"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2020-NR049568"],"award-info":[{"award-number":["RS-2020-NR049568"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2022-NR067329"],"award-info":[{"award-number":["RS-2022-NR067329"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014189","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry","doi-asserted-by":"publisher","award":["RS-2024-00397026"],"award-info":[{"award-number":["RS-2024-00397026"]}],"id":[{"id":"10.13039\/501100014189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014189","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry","doi-asserted-by":"publisher","award":["RS-2026-25519399"],"award-info":[{"award-number":["RS-2026-25519399"]}],"id":[{"id":"10.13039\/501100014189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023443","name":"Commercializations Promotion Agency for R and D Outcomes","doi-asserted-by":"publisher","award":["RS-2025-25430866"],"award-info":[{"award-number":["RS-2025-25430866"]}],"id":[{"id":"10.13039\/501100023443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    Biomedical membranes are among the most widely used biomaterials in clinical regenerative medicine due to their ease of application, biocompatibility, and versatility across multiple tissues. However, conventional membranes have been limited to passive roles serving as physical barriers or wound coverings without an intrinsic capability to initiate or orchestrate true tissue regeneration. Here, we report the design, development, and clinical validation of an active tissue-regenerative biomedical membrane patch, aiming to advance biomedical membranes from passive protection toward active human tissue regeneration. In this study, we developed a multifunctional, collagen-coated polylactic-\n                    <jats:italic toggle=\"yes\">co<\/jats:italic>\n                    -glycolic acid nanotopographical scaffold (Col-NS) that mimics the native extracellular matrix to enhance soft- and hard-tissue regeneration. In a clinical trial for laser-induced human skin injury, Col-NS substantially improved healing outcomes, achieving accelerated wound contraction, dermal volume restoration, reduced surface roughness, and decreased transepidermal water loss relative to standard care. In human dental procedures, including alveolar ridge preservation and guided bone regeneration, Col-NS enabled robust bone formation, stable implant osseointegration, and complication-free recovery. These findings demonstrate the translational feasibility of an extracellular-matrix-mimetic nanoengineered scaffold across soft- and hard-tissue applications and support its potential as a clinically relevant platform for regenerative medicine. This work may contribute to broadening the clinical role of biomedical patches from passive coverings toward active regenerative platforms.\n                  <\/jats:p>","DOI":"10.34133\/bmr.0414","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T18:52:27Z","timestamp":1786474347000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Regenerative Nano-scaffolds for Tissue Engineering: From Bench to Clinical Translation"],"prefix":"10.34133","volume":"30","author":[{"given":"Woochan","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Convergence Biosystems Engineering, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Department of Rural and Biosystems Engineering, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Interdisciplinary Program in IT-Bio Convergence System, \rChonnam National University, Gwangju 61186, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangbae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biosystems Engineering, \rSeoul National University, Seoul 08826, Republic of Korea."},{"name":"Integrated Major in Global Smart Farm, College of Agriculture and Life Sciences, \rSeoul National University, Seoul 08826, Republic of Korea."},{"name":"Research Institute for Agriculture and Life Sciences, \rSeoul National University, Seoul 08826, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Beom","sequence":"additional","affiliation":[{"name":"Institute of Nano-Stem Cells Therapeutics, \rNANOBIOSYSTEM Co., Ltd., Gwangju 61003, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selin","family":"Choi","sequence":"additional","affiliation":[{"name":"Institute of Nano-Stem Cells Therapeutics, \rNANOBIOSYSTEM Co., Ltd., Gwangju 61003, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Won","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Nano-Stem Cells Therapeutics, \rNANOBIOSYSTEM Co., Ltd., Gwangju 61003, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dream","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Convergence Biosystems Engineering, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Department of Rural and Biosystems Engineering, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Interdisciplinary Program in IT-Bio Convergence System, \rChonnam National University, Gwangju 61186, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinyull","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Convergence Biosystems Engineering, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Department of Rural and Biosystems Engineering, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Interdisciplinary Program in IT-Bio Convergence System, \rChonnam National University, Gwangju 61186, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshita","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Convergence Biosystems Engineering, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Department of Rural and Biosystems Engineering, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Interdisciplinary Program in IT-Bio Convergence System, \rChonnam National University, Gwangju 61186, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaeyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Convergence Biosystems Engineering, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Department of Rural and Biosystems Engineering, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Interdisciplinary Program in IT-Bio Convergence System, \rChonnam National University, Gwangju 61186, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Pyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry, \rChosun University, Gwangju 61452, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-8215","authenticated-orcid":true,"given":"Jangho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Convergence Biosystems Engineering, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Department of Rural and Biosystems Engineering, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Interdisciplinary Program in IT-Bio Convergence System, \rChonnam National University, Gwangju 61186, Republic of Korea."},{"name":"Institute of Nano-Stem Cells Therapeutics, \rNANOBIOSYSTEM Co., Ltd., Gwangju 61003, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200802977"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230078"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.617141"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c00045"},{"key":"e_1_3_4_6_2","first-page":"460","article-title":"Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing","volume":"10","author":"He S","year":"2022","unstructured":"He S, Walimbe T, Chen H, Gao K, Kumar P, Wei Y, Hao D, Liu R, Farmer DL, Lam KS. 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