{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:07:26Z","timestamp":1790071646544,"version":"4.0.1"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"name":"Science and Technology Project of Wenzhou","award":["Y2023045"],"award-info":[{"award-number":["Y2023045"]}]},{"name":"Medical and Health Science & Technology Program Project of ZheJiang","award":["2024KY1631"],"award-info":[{"award-number":["2024KY1631"]}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    The demand for effective therapeutics addressing osteosarcoma necessitates multifunctional solutions integrating both antineoplastic and osteogenic properties. This study presents a novel approach involving a 3-dimensional (3D)-printed polycaprolactone (PCL) scaffold integrated with piezoelectric iron (II) tungstate (FeWO\n                    <jats:sub>4<\/jats:sub>\n                    ) nanorods (NRs), designed to concurrently combat osteosarcoma and foster bone regeneration. Through the amalgamation of FeWO\n                    <jats:sub>4<\/jats:sub>\n                    NRs\u2019 piezoelectric catalytic characteristics and PCL scaffold\u2019s structural attributes, the composite scaffolds exhibit dual functionality: inducing oxidative stress in tumor cells via ultrasound-triggered piezo-sonoydnamic effects while facilitating stem cell attachment and proliferation without ultrasound. The physicochemical attributes and catalytic efficacy of the composite scaffolds are meticulously investigated. Both in\u00a0vitro and in\u00a0vivo tests confirm the strong ultrasound-triggered antitumor and ultrasound-free bone-forming effects of the PCL@FeWO\n                    <jats:sub>4<\/jats:sub>\n                    composite scaffold. This study introduces a novel class of piezoelectric nanomaterial-functionalized 3D-printing scaffolds, presenting new avenues for ultrasound-triggered osteosarcoma therapy and ultrasound-free bone regeneration.\n                  <\/jats:p>","DOI":"10.34133\/bmr.0420","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:37:36Z","timestamp":1788979056000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Piezoelectric Iron (II) Tungstate-Integrated Three-Dimensional-Printed Polycaprolactone Scaffolds for Ultrasound-Triggered Osteosarcoma Therapy and Ultrasound-Free Bone Repair"],"prefix":"10.34133","volume":"30","author":[{"given":"Jiongming","family":"You","sequence":"first","affiliation":[{"name":"Department of Orthopedic, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou 325000, Zhejiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biaotong","family":"Huang","sequence":"additional","affiliation":[{"name":"Wenzhou Institute, \rShanghai University, Wenzhou 325000, Zhejiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinsheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou 325000, Zhejiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3014-8888","authenticated-orcid":false,"given":"Xinxing","family":"Sun","sequence":"additional","affiliation":[{"name":"Wenzhou Institute, \rShanghai University, Wenzhou 325000, Zhejiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-4490","authenticated-orcid":false,"given":"Na","family":"Liang","sequence":"additional","affiliation":[{"name":"Wenzhou Institute, \rShanghai University, Wenzhou 325000, Zhejiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Wenzhou Institute, \rShanghai University, Wenzhou 325000, Zhejiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5144-4889","authenticated-orcid":true,"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou 325000, Zhejiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100318"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/20417314231170371"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c20145"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-022-01191-w"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB00931E"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1515\/ntrev-2023-0572"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/D4TB00214H"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2023.110641"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901511"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705611"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2023.108342"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202208128"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c01968"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2024.109530"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101860"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.129509"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2022.05.225"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfin.2023.102882"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.03.189"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2023.136275"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2022.133705"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100719"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101884"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep08124"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2019.104083"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03325-x"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC00385F"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202215295"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.111295"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c01553"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2012.08.007"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2014.01.004"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5CP04046A"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-023-5543-z"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2013.05.017"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.128408"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100150"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2024.102060"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2023.09.001"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.110643"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202477"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2021.10.070"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB00687A"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.11.064"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300038"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202309042"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202942"}],"container-title":["Biomaterials Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.34133\/bmr.0420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:25:03Z","timestamp":1790069103000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.34133\/bmr.0420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":47,"alternative-id":["10.34133\/bmr.0420"],"URL":"https:\/\/doi.org\/10.34133\/bmr.0420","relation":{},"ISSN":["2055-7124"],"issn-type":[{"value":"2055-7124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"assertion":[{"value":"2026-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"0420"}}