{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:50:32Z","timestamp":1791449432317,"version":"4.3.3"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201644"],"award-info":[{"award-number":["81201644"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572858"],"award-info":[{"award-number":["81572858"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302319"],"award-info":[{"award-number":["82302319"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    Microwave ablation (MWA) holds great promise for hepatocellular carcinoma but is often limited by incomplete tumor eradication and recurrence. Here, we report a tumor-killing nanoimmunoreactor driven by endogenous immune cues that synergizes with MWA to eliminate residual tumors and activate systemic antitumor immunity. The 17-AAG\u2013MnO\n                    <jats:sub>2<\/jats:sub>\n                    PEG nanoimmunoreactor consists of a self-responsive PEGylated MnO\n                    <jats:sub>2<\/jats:sub>\n                    platform loaded with the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG), which is designed to respond to the oxidative tumor microenvironment. 17-AAG disrupts tumor cell thermotolerance, enhancing sensitivity to microwave-induced thermal stress, thereby improving ablation efficacy and inducing immunogenic cell death. PEGylation facilitates tumor-targeted accumulation, while the degradable MnO\n                    <jats:sub>2<\/jats:sub>\n                    responds to hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) and tumor debris generated after MWA, enabling sustained local drug release. The combination treatment promotes dendritic cell maturation and T cell infiltration, effectively suppresses residual tumor regrowth, reduces the risk of metastasis, and establishes durable immune memory. By leveraging post-ablation tumor debris and microenvironmental cues, this strategy couples local tumor ablation with systemic antitumor immunity, providing a mechanistically distinct paradigm for durable cancer therapy.\n                  <\/jats:p>","DOI":"10.34133\/bmr.0421","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:41:31Z","timestamp":1790019691000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Vulnerability and Immunogenic Cell Death under Microwave Ablation for Synergistic Treatment of Hepatocellular Carcinoma"],"prefix":"10.34133","volume":"30","author":[{"given":"Zide","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, \rSouthern Medical University, Guangdong 510080, China."},{"name":"School of Medicine, \rSouth China University of Technology, Guangdong 510006, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, \rSichuan University, Chengdu 610041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufu","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, \rSichuan University, Chengdu 610041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengni","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, \rEast China Normal University, Shanghai 200241, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqing","family":"Huang","sequence":"additional","affiliation":[{"name":"The Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Cancer, Liver Cancer Research Center, \rTianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4437-3581","authenticated-orcid":true,"given":"Kefei","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery, West China Hospital, \rSichuan University, Chengdu 610041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24604-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c10714"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406975"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0992-4"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1808"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115070"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/D4TB00403E"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.01.009"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00484-9"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202313389"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01797-9"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01046-3"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202311622"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202402981"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24112-w"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303299"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202413181"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202403118"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.114553"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2020.7597"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403764"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45668-3"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2018.07.005"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202209245"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00008.2020"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202101572"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2021.03.065"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2026.115592"}],"container-title":["Biomaterials 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