{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:40:51Z","timestamp":1792572051593,"version":"4.5.0"},"reference-count":46,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22207066"],"award-info":[{"award-number":["22207066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QB141"],"award-info":[{"award-number":["ZR2024QB141"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Traditional Chinese Medicine Science and Technology Project of Shandong Province","award":["Q-2022142"],"award-info":[{"award-number":["Q-2022142"]}]},{"name":"Project for Scientific Research Innovation Team of Young Scholars in Colleges and Universities of Shandong Province","award":["2022KJ196"],"award-info":[{"award-number":["2022KJ196"]}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Biomater Res"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    Bacterial infections compromise wound healing and represent a growing threat in the era of rising antibiotic resistance. Herein, we developed a multifunctional platform (CN@La@B) that combines bacterial capture, membrane sensitization, visible-light-triggered antibacterial activity, and anti-inflammatory effects. The CN@La@B was prepared by immobilizing dendritic mesoporous lanthanide hydroxide [La(OH)\n                    <jats:sub>3<\/jats:sub>\n                    ] nanoparticles (La NPs) onto graphite carbon nitride (g-C\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    ) nanosheets to form a topologically structured La(OH)\n                    <jats:sub>3<\/jats:sub>\n                    @g-C\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    (CN@La) heterostructure, followed by loading of the anti-inflammatory agent berberine. The spiky topological La NPs attached to bacterial surfaces, thereby promoting phospholipid dephosphorylation and enhancing membrane permeability. Under visible-light irradiation, electrons from g-C\n                    <jats:sub>3<\/jats:sub>\n                    N\n                    <jats:sub>4<\/jats:sub>\n                    nanosheets were photoexcited to the conduction band and subsequently transferred to La NPs, enabling electron\u2013hole separation and reactive oxygen species generation to eradicate bacteria. Meanwhile, berberine loaded onto the CN@La@B platform helped regulate the wound immune microenvironment. Collectively, both in\u00a0vitro and in\u00a0vivo evaluations demonstrated that the CN@La@B killed bacteria and disrupted biofilms, while also modulating inflammation, speeding up wound closure, and supporting tissue regeneration. These findings suggest that CN@La@B is a promising multifunctional platform for infected wound treatment, based on a \u201cflypaper-mimicked\u201d antibacterial strategy that integrates bacterial capture, membrane sensitization, reactive oxygen species generation, and immunomodulation.\n                  <\/jats:p>","DOI":"10.34133\/bmr.0436","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:33:23Z","timestamp":1791552803000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Visible-Light-Enhanced Lanthanide Heterostructure with Synergistic Antibacterial and Anti-inflammatory Activity to Accelerate Wound Healing"],"prefix":"10.34133","volume":"30","author":[{"given":"Ying","family":"Qu","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital, School of Public Health, Medical Science and Technology Innovation Center, \rShandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital, School of Public Health, Medical Science and Technology Innovation Center, \rShandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Song","sequence":"additional","affiliation":[{"name":"School of Polymer Science and Engineering, \rQingdao University of Science and Technology, Qingdao 266042, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital, School of Public Health, Medical Science and Technology Innovation Center, \rShandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital, School of Public Health, Medical Science and Technology Innovation Center, \rShandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejian","family":"Wu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital, School of Public Health, Medical Science and Technology Innovation Center, \rShandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Han","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital, School of Public Health, Medical Science and Technology Innovation Center, \rShandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, College of Animal Science and Technology, \rChina Agricultural University, Beijing 100193, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4449-354X","authenticated-orcid":true,"given":"Huilin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shandong Medical and Pharmaceutical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-1089","authenticated-orcid":true,"given":"Cong","family":"Song","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital, School of Public Health, Medical Science and Technology Innovation Center, \rShandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3778-2415","authenticated-orcid":true,"given":"Runxiao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital, School of Public Health, Medical Science and Technology Innovation Center, \rShandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202507797"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.72911"},{"issue":"1","key":"e_1_3_4_4_2","article-title":"Beyond antibiotics: Engineered metal nanozymes for resistance-evading antibacterial therapy","volume":"24","author":"Wang Y","year":"2026","unstructured":"Wang Y, Wu C, Sun X, Ye T, Liu C, Liu A, Wu X, Pang X. 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