{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:42:03Z","timestamp":1792399323421,"version":"4.4.0"},"reference-count":233,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"name":"the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2025-I2M-KJ-003"],"award-info":[{"award-number":["2025-I2M-KJ-003"]}]},{"name":"the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2025-I2M-XHZY-016"],"award-info":[{"award-number":["2025-I2M-XHZY-016"]}]},{"name":"the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2025-I2M-GCC-002"],"award-info":[{"award-number":["2025-I2M-GCC-002"]}]},{"name":"the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2023-I2M-2-004"],"award-info":[{"award-number":["2023-I2M-2-004"]}]},{"name":"the National High Level Hospital Clinical Research Funding","award":["2025-LYZX-D-B04"],"award-info":[{"award-number":["2025-LYZX-D-B04"]}]},{"DOI":"10.13039\/501100018609","name":"the National High Level Hospital Clinical Research Funding","doi-asserted-by":"publisher","award":["2025-LYZX-C-B01"],"award-info":[{"award-number":["2025-LYZX-C-B01"]}],"id":[{"id":"10.13039\/501100018609","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the National Key Research and Development Program of China","award":["2023YFC3503200"],"award-info":[{"award-number":["2023YFC3503200"]}]},{"name":"the National Natural Science Foundation of China","award":["8258820001"],"award-info":[{"award-number":["8258820001"]}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Cancer Commun"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>Squamous cell carcinomas (SCCs) develop from the stratified epithelia of the esophagus, head and neck, lung, and skin, providing a tractable model to investigate how altered epithelial fields progress toward invasive cancer. Across SCC subtypes, evolution often begins before overt malignancy, with age- and exposure-associated mutant clones expanding within histologically normal epithelia. As lesions advance, early driver selection becomes coupled to copy number alterations, chromosomal instability, and epigenetic remodeling, whereas later stages are shaped by branching diversification, cellular plasticity, and regionally constrained selection. Despite tissue-specific differences, several recurrent principles emerge, including clonal expansion within mutated normal fields, transition bottlenecks marked by genome-scale instability, and the spatial organization of subclonal architecture and invasive-front states. In this review, we synthesize recent progress in the temporal ordering and spatial patterning of SCC evolution and discuss how genetic alterations, epigenetic remodeling, and tissue ecology jointly drive disease progression. We further highlight the implications for early interception, biomarker development, immune evasion, and evolution-informed prevention and therapy.<\/jats:p>","DOI":"10.34133\/cancomm.0051","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:43:51Z","timestamp":1787240631000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporal Analysis of Molecular Continuity in Pathogenesis of Squamous Cell Carcinoma: From Normal Epithelium to Precancerous Lesions and Carcinoma"],"prefix":"10.34133","volume":"46","author":[{"given":"Lan","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Etiology and Carcinogenesis, National Cancer Center\/National Clinical Research Center\/Cancer Hospital, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."},{"name":"Key Laboratory of Cancer Genomic Biology, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Etiology and Carcinogenesis, National Cancer Center\/National Clinical Research Center\/Cancer Hospital, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."},{"name":"Key Laboratory of Cancer Genomic Biology, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Etiology and Carcinogenesis, National Cancer Center\/National Clinical Research Center\/Cancer Hospital, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."},{"name":"Key Laboratory of Cancer Genomic Biology, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Etiology and Carcinogenesis, National Cancer Center\/National Clinical Research Center\/Cancer Hospital, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."},{"name":"Key Laboratory of Cancer Genomic Biology, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yancheng","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Etiology and Carcinogenesis, National Cancer Center\/National Clinical Research Center\/Cancer Hospital, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."},{"name":"Key Laboratory of Cancer Genomic Biology, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Etiology and Carcinogenesis, National Cancer Center\/National Clinical Research Center\/Cancer Hospital, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."},{"name":"Key Laboratory of Cancer Genomic Biology, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaosen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Etiology and Carcinogenesis, National Cancer Center\/National Clinical Research Center\/Cancer Hospital, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."},{"name":"Key Laboratory of Cancer Genomic Biology, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Etiology and Carcinogenesis, National Cancer Center\/National Clinical Research Center\/Cancer Hospital, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."},{"name":"Key Laboratory of Cancer Genomic Biology, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine, \rNanjing Medical University, Nanjing, Jiangsu, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Etiology and Carcinogenesis, National Cancer Center\/National Clinical Research Center\/Cancer Hospital, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."},{"name":"Key Laboratory of Cancer Genomic Biology, \rChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China."},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine, \rNanjing Medical University, Nanjing, Jiangsu, P. R. China."},{"name":"Chinese Academy of Medical Sciences (CAMS) Oxford Institute, Chinese Academy of Medical Sciences, Beijing, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"issue":"1","key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41392-024-01848-7","article-title":"Tumor initiation and early tumorigenesis: Molecular mechanisms and interventional targets","volume":"9","author":"Zhang S","year":"2024","unstructured":"Zhang S, Xiao X, Yi Y, Wang X, Zhu L, Shen Y, Lin D, Wu C. Tumor initiation and early tumorigenesis: Molecular mechanisms and interventional targets. Signal Transduct Target Ther. 2024;9(1):149.","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.016"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2019.03.003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.04.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.959840"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10762"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1059"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.018"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.102"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108251","article-title":"Game of clones: Battles in the field of carcinogenesis","volume":"237","author":"Rahal Z","year":"2022","unstructured":"Rahal Z, Sinjab A, Wistuba II, Kadara H. Game of clones: Battles in the field of carcinogenesis. Pharmacol Ther. 2022;237: Article 108251.","journal-title":"Pharmacol Ther"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00335-3"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau3879"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0811-x"},{"issue":"5","key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q","article-title":"Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin","volume":"6","author":"Slaughter DP","year":"1953","unstructured":"Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer. 1953;6(5):963\u2013968.","journal-title":"Cancer"},{"issue":"8","key":"e_1_3_2_17_2","first-page":"1727","article-title":"A genetic explanation of Slaughter\u2019s concept of field cancerization: Evidence and clinical implications","volume":"63","author":"Braakhuis BJ","year":"2003","unstructured":"Braakhuis BJ, Tabor MP, Kummer JA, Leemans CR, Brakenhoff RH. A genetic explanation of Slaughter\u2019s concept of field cancerization: Evidence and clinical implications. Cancer Res. 2003;63(8):1727\u20131730.","journal-title":"Cancer Res"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3261"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0114-6"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1616288"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3683"},{"issue":"1","key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1038\/s41467-019-09255-1","article-title":"Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma","volume":"10","author":"Yan T","year":"2019","unstructured":"Yan T, Cui H, Zhou Y, Yang B, Kong P, Zhang Y, Liu Y, Wang B, Cheng Y, Li J, et al. Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma. Nat Commun. 2019;10(1):1670.","journal-title":"Nat Commun"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28150"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12626"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.01.010"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.04.014"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-2649"},{"issue":"2","key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41559-021-01615-9","article-title":"Spatial structure governs the mode of tumour evolution","volume":"6","author":"Noble R","year":"2022","unstructured":"Noble R, Burri D, Le Sueur C, Lemant J, Viossat Y, Kather JN, Beerenwinkel N. Spatial structure governs the mode of tumour evolution. Nat Ecol Evol. 2022;6(2):207\u2013217.","journal-title":"Nat Ecol Evol"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2764"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235122"},{"issue":"7793","key":"e_1_3_2_31_2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41586-020-1969-6","article-title":"Pan-cancer analysis of whole genomes","volume":"578","author":"ICGC\/TCGA Pan-Cancer Analysis of Whole Genomes Consortium","year":"2020","unstructured":"ICGC\/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature. 2020;578(7793):82\u201393.","journal-title":"Nature"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1965-x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08822"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2760"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0165-1"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0584-7"},{"issue":"7793","key":"e_1_3_2_37_2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41586-019-1913-9","article-title":"Patterns of somatic structural variation in human cancer genomes","volume":"578","author":"Li Y","year":"2020","unstructured":"Li Y, Roberts ND, Wala JA, Shapira O, Schumacher SE, Kumar K, Khurana E, Waszak S, Korbel JO, Haber JE, et al. Patterns of somatic structural variation in human cancer genomes. Nature. 2020;578(7793):112\u2013121.","journal-title":"Nature"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03133-3"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.021"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.054"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0576-7"},{"issue":"1","key":"e_1_3_2_42_2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028373","article-title":"The role of aneuploidy in cancer evolution","volume":"7","author":"Sansregret L","year":"2017","unstructured":"Sansregret L, Swanton C. The role of aneuploidy in cancer evolution. Cold Spring Harb Perspect Med. 2017;7(1): Article a028373.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0171-x"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2762"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2203"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12477"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3729"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1943-3"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11881"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgw055"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17676"},{"issue":"1","key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1038\/s41467-018-04002-4","article-title":"Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair","volume":"9","author":"Haradhvala NJ","year":"2018","unstructured":"Haradhvala NJ, Kim J, Maruvka YE, Polak P, Rosebrock D, Livitz D, Hess JM, Leshchiner I, Kamburov A, Mouw KW, et al. Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair. Nat Commun. 2018;9(1):1746.","journal-title":"Nat Commun"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3310"},{"issue":"1","key":"e_1_3_2_54_2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.celrep.2018.03.063","article-title":"Genomic, pathway network, and immunologic features distinguishing squamous carcinomas","volume":"23","author":"Campbell JD","year":"2018","unstructured":"Campbell JD, Yau C, Bowlby R, Liu Y, Brennan K, Fan H, Taylor AM, Wang C, Walter V, Akbani R, et al. Genomic, pathway network, and immunologic features distinguishing squamous carcinomas. Cell Rep. 2018;23(1):194\u2013212.","journal-title":"Cell Rep"},{"issue":"2","key":"e_1_3_2_55_2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ajhg.2015.12.013","article-title":"Whole-genome sequencing reveals diverse models of structural variations in esophageal squamous cell carcinoma","volume":"98","author":"Cheng C","year":"2016","unstructured":"Cheng C, Zhou Y, Li H, Xiong T, Li S, Bi Y, Kong P, Wang F, Cui H, Li Y, et al. Whole-genome sequencing reveals diverse models of structural variations in esophageal squamous cell carcinoma. Am J Hum Genet. 2016;98(2):256\u2013274.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3076"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13176"},{"issue":"5","key":"e_1_3_2_58_2","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1053\/j.gastro.2016.01.035","article-title":"Genomic landscape of esophageal squamous cell carcinoma in a Japanese population","volume":"150","author":"Sawada G","year":"2016","unstructured":"Sawada G, Niida A, Uchi R, Hirata H, Shimamura T, Suzuki Y, Shiraishi Y, Chiba K, Imoto S, Takahashi Y, et al. Genomic landscape of esophageal squamous cell carcinoma in a Japanese population. Gastroenterology. 2016;150(5):1171\u20131182.","journal-title":"Gastroenterology"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.060"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.02.017"},{"issue":"1","key":"e_1_3_2_61_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41525-021-00226-4","article-title":"The landscape of driver mutations in cutaneous squamous cell carcinoma","volume":"6","author":"Chang D","year":"2021","unstructured":"Chang D, Shain AH. The landscape of driver mutations in cutaneous squamous cell carcinoma. NPJ Genom Med. 2021;6(1):61.","journal-title":"NPJ Genom Med"},{"issue":"7536","key":"e_1_3_2_62_2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nature14129","article-title":"Comprehensive genomic characterization of head and neck squamous cell carcinomas","volume":"517","author":"Cancer Genome Atlas Network","year":"2015","unstructured":"Cancer Genome Atlas Network. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015;517(7536):576\u2013582.","journal-title":"Nature"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3971"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.58"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.009"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00302-4"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4409"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2328"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3394"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa6204"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0014-x"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3962"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03965-7"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.05.012"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.12.006"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-026-10157-8"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07663-y"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.027"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22794"},{"issue":"6348","key":"e_1_3_2_81_2","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal2380","article-title":"Epigenetic plasticity and the hallmarks of cancer","volume":"357","author":"Flavahan WA","year":"2017","unstructured":"Flavahan WA, Gaskell E, Bernstein BE. Epigenetic plasticity and the hallmarks of cancer. Science. 2017;357(6348): Article eaal2380.","journal-title":"Science"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.044"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.039"},{"issue":"1","key":"e_1_3_2_84_2","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/s41467-023-36558-1","article-title":"Tracking the evolution of esophageal squamous cell carcinoma under dynamic immune selection by multi-omics sequencing","volume":"14","author":"Cui S","year":"2023","unstructured":"Cui S, McGranahan N, Gao J, Chen P, Jiang W, Yang L, Ma L, Liao J, Xie T, Xie C, et al. Tracking the evolution of esophageal squamous cell carcinoma under dynamic immune selection by multi-omics sequencing. Nat Commun. 2023;14(1):892.","journal-title":"Nat Commun"},{"issue":"11","key":"e_1_3_2_85_2","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1493","article-title":"Multi-omics analyses reveal spatial heterogeneity in primary and metastatic oesophageal squamous cell carcinoma","volume":"13","author":"Huang H","year":"2023","unstructured":"Huang H, Li N, Liang Y, Li R, Tong X, Xiao J, Tang H, Jiang D, Xie K, Fang C, et al. Multi-omics analyses reveal spatial heterogeneity in primary and metastatic oesophageal squamous cell carcinoma. Clin Transl Med. 2023;13(11): Article e1493.","journal-title":"Clin Transl Med"},{"issue":"7636","key":"e_1_3_2_86_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature20805","article-title":"Integrated genomic characterization of oesophageal carcinoma","volume":"541","author":"The Cancer Genome Atlas Research Network","year":"2017","unstructured":"The Cancer Genome Atlas Research Network. Integrated genomic characterization of oesophageal carcinoma. Nature. 2017;541(7636):169\u2013175.","journal-title":"Nature"},{"issue":"1","key":"e_1_3_2_87_2","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1186\/s12885-022-10256-5","article-title":"Temporal and spatial characteristics of tumor evolution in a mouse model of oral squamous cell carcinoma","volume":"22","author":"Cao Y","year":"2022","unstructured":"Cao Y, Dong H, Li G, Wei H, Xie C, Tuo Y, Chen N, Yu D. Temporal and spatial characteristics of tumor evolution in a mouse model of oral squamous cell carcinoma. BMC Cancer. 2022;22(1):1209.","journal-title":"BMC Cancer"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03836-1"},{"issue":"5","key":"e_1_3_2_89_2","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwae150","article-title":"Immune-tumor interaction dictates spatially directed evolution of esophageal squamous cell carcinoma","volume":"11","author":"Zhou Y","year":"2024","unstructured":"Zhou Y, Mo S, Cui H, Sun R, Zhang W, Zhuang X, Xu E, Li H, Cheng Y, Meng Y, et al. Immune-tumor interaction dictates spatially directed evolution of esophageal squamous cell carcinoma. Natl Sci Rev. 2024;11(5): Article nwae150.","journal-title":"Natl Sci Rev"},{"issue":"6752","key":"e_1_3_2_90_2","doi-asserted-by":"crossref","DOI":"10.1126\/science.ads9145","article-title":"Aberrant basal cell clonal dynamics shape early lung carcinogenesis","volume":"388","author":"G\u00f3mez-L\u00f3pez S","year":"2025","unstructured":"G\u00f3mez-L\u00f3pez S, Alhendi ASN, Przybilla MJ, Bordeu I, Whiteman ZE, Butler T, Rouhani MJ, Kalinke L, Uddin I, Otter KEJ, et al. Aberrant basal cell clonal dynamics shape early lung carcinogenesis. Science. 2025;388(6752): Article eads9145.","journal-title":"Science"},{"issue":"1","key":"e_1_3_2_91_2","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1038\/s41598-019-39636-x","article-title":"The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer","volume":"9","author":"Gallaher JA","year":"2019","unstructured":"Gallaher JA, Brown JS, Anderson ARA. The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer. Sci Rep. 2019;9(1):2425.","journal-title":"Sci Rep"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0624-3"},{"issue":"1","key":"e_1_3_2_93_2","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1038\/s41467-023-40822-9","article-title":"Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression","volume":"14","author":"Bailey P","year":"2023","unstructured":"Bailey P, Ridgway RA, Cammareri P, Treanor-Taylor M, Bailey U-M, Schoenherr C, Bone M, Schreyer D, Purdie K, Thomson J, et al. Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Nat Commun. 2023;14(1):5211.","journal-title":"Nat Commun"},{"key":"e_1_3_2_94_2","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85270","article-title":"Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma","volume":"12","author":"Zou D-D","year":"2023","unstructured":"Zou D-D, Sun Y-Z, Li X-J, Wu W-J, Xu D, He Y-T, Qi J, Tu Y, Tang Y, Tu Y-H, et al. Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma. eLife. 2023;12: Article e85270.","journal-title":"eLife"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0006-7"},{"issue":"1","key":"e_1_3_2_96_2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13073-024-01422-4","article-title":"Spatial transcriptome profiling identifies DTX3L and BST2 as key biomarkers in esophageal squamous cell carcinoma tumorigenesis","volume":"16","author":"Li R","year":"2024","unstructured":"Li R, Li N, Yang Q, Tong X, Wang W, Li C, Zhao J, Jiang D, Huang H, Fang C, et al. Spatial transcriptome profiling identifies DTX3L and BST2 as key biomarkers in esophageal squamous cell carcinoma tumorigenesis. Genome Med. 2024;16(1):148.","journal-title":"Genome Med"},{"issue":"3","key":"e_1_3_2_97_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0092-8674(00)00139-2","article-title":"MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis","volume":"103","author":"Coussens LM","year":"2000","unstructured":"Coussens LM, Tinkle CL, Hanahan D, Werb Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell. 2000;103(3):481\u2013490.","journal-title":"Cell"},{"issue":"1","key":"e_1_3_2_98_2","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1038\/s41467-018-07767-w","article-title":"Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer","volume":"9","author":"Jia Q","year":"2018","unstructured":"Jia Q, Wu W, Wang Y, Alexander PB, Sun C, Gong Z, Cheng JN, Sun H, Guan Y, Xia X, et al. Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer. Nat Commun. 2018;9(1):5361.","journal-title":"Nat Commun"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1032-7"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1092"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1907-7"},{"issue":"1","key":"e_1_3_2_102_2","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.1038\/s41467-022-33945-y","article-title":"p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition","volume":"13","author":"Murai K","year":"2022","unstructured":"Murai K, Dentro S, Ong SH, Sood R, Fernandez-Antoran D, Herms A, Kostiou V, Abnizova I, Hall BA, Gerstung M, et al. p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition. Nat Commun. 2022;13(1):6206.","journal-title":"Nat Commun"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01891-8"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01280-z"},{"issue":"6","key":"e_1_3_2_105_2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/ncb2963","article-title":"Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change","volume":"16","author":"Alcolea MP","year":"2014","unstructured":"Alcolea MP, Greulich P, Wabik A, Frede J, Simons BD, Jones PH. Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change. Nat Cell Biol. 2014;16(6):615\u2013622.","journal-title":"Nat Cell Biol"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01875-8"},{"issue":"1","key":"e_1_3_2_107_2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/s41467-024-55660-6","article-title":"YAP-driven oral epithelial stem cell malignant reprogramming at single cell resolution","volume":"16","author":"Faraji F","year":"2025","unstructured":"Faraji F, Ramirez SI, Clubb L, Sato K, Burghi V, Hoang TS, Officer A, Anguiano Quiroz PY, Galloway WM, Mikulski Z, et al. YAP-driven oral epithelial stem cell malignant reprogramming at single cell resolution. Nat Commun. 2025;16(1):498.","journal-title":"Nat Commun"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.08.017"},{"issue":"3","key":"e_1_3_2_109_2","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1158\/1078-0432.CCR-22-2210","article-title":"Elucidating the genetic landscape of oral leukoplakia to predict malignant transformation","volume":"29","author":"Wils LJ","year":"2023","unstructured":"Wils LJ, Poell JB, Brink A, Evren I, Brouns ER, de Visscher JGAM, Bloemena E, Brakenhoff RH. Elucidating the genetic landscape of oral leukoplakia to predict malignant transformation. Clin Cancer Res. 2023;29(3):602\u2013613.","journal-title":"Clin Cancer Res"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0333-6"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01010-0"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.11.003"},{"issue":"1","key":"e_1_3_2_113_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41392-025-02309-5","article-title":"Aberrant notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma","volume":"10","author":"Li C","year":"2025","unstructured":"Li C, Wu P, Xie X, Chen X, Chen L, Zhu L, Xuan Z, Liu T, Tan W, Zhang S, et al. Aberrant notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma. Signal Transduct Target Ther. 2025;10(1):233.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"e_1_3_2_114_2","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1038\/s41467-023-37440-w","article-title":"Integrative proteogenomic characterization of early esophageal cancer","volume":"14","author":"Li L","year":"2023","unstructured":"Li L, Jiang D, Zhang Q, Liu H, Xu F, Guo C, Qin Z, Wang H, Feng J, Liu Y, et al. Integrative proteogenomic characterization of early esophageal cancer. Nat Commun. 2023;14(1):1666.","journal-title":"Nat Commun"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00224-3"},{"issue":"16","key":"e_1_3_2_116_2","first-page":"4757","article-title":"Molecular changes associated with oral dysplasia progression and acquisition of immortality: Potential for its reversal by 5-azacytidine","volume":"62","author":"McGregor F","year":"2002","unstructured":"McGregor F, Muntoni A, Fleming J, Brown J, Felix DH, MacDonald DG, Parkinson EK, Harrison PR. Molecular changes associated with oral dysplasia progression and acquisition of immortality: Potential for its reversal by 5-azacytidine. Cancer Res. 2002;62(16):4757\u20134766.","journal-title":"Cancer Res"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.2940130408"},{"issue":"1","key":"e_1_3_2_118_2","doi-asserted-by":"crossref","first-page":"11992","DOI":"10.1038\/s41598-019-48229-7","article-title":"Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy","volume":"9","author":"Veeramachaneni R","year":"2019","unstructured":"Veeramachaneni R, Walker T, Revil T, Weck A, Badescu D, O\u2019Sullivan J, Higgins C, Elliott L, Liloglou T, Risk JM, et al. Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy. Sci Rep. 2019;9(1):11992.","journal-title":"Sci Rep"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3873"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1208130"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1206923"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0537"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.198"},{"issue":"1","key":"e_1_3_2_124_2","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1038\/s41467-025-65687-y","article-title":"Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma","volume":"16","author":"Tandukar B","year":"2025","unstructured":"Tandukar B, Deivendran D, Chen L, Bandari AK, Cruz-Pacheco N, Sharma H, Wang M, Xu A, Chen DB, George CD, et al. Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma. Nat Commun. 2025;16(1):10663.","journal-title":"Nat Commun"},{"issue":"7832","key":"e_1_3_2_125_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41586-020-2698-6","article-title":"Pervasive chromosomal instability and karyotype order in tumour evolution","volume":"587","author":"Watkins TBK","year":"2020","unstructured":"Watkins TBK, Lim EL, Petkovic M, Elizalde S, Birkbak NJ, Wilson GA, Moore DA, Gr\u00f6nroos E, Rowan A, Dewhurst SM, et al. Pervasive chromosomal instability and karyotype order in tumour evolution. Nature. 2020;587(7832):126\u2013132.","journal-title":"Nature"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14143382"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00928-6"},{"issue":"1","key":"e_1_3_2_128_2","doi-asserted-by":"crossref","first-page":"15290","DOI":"10.1038\/ncomms15290","article-title":"Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations","volume":"8","author":"Chang J","year":"2017","unstructured":"Chang J, Tan W, Ling Z, Xi R, Shao M, Chen M, Luo Y, Zhao Y, Liu Y, Huang X, et al. Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations. Nat Commun. 2017;8(1):15290.","journal-title":"Nat Commun"},{"issue":"5","key":"e_1_3_2_129_2","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.ccell.2023.03.001","article-title":"Epithelial cells activate fibroblasts to promote esophageal cancer development","volume":"41","author":"Chen Y","year":"2023","unstructured":"Chen Y, Zhu S, Liu T, Zhang S, Lu J, Fan W, Lin L, Xiang T, Yang J, Zhao X, et al. Epithelial cells activate fibroblasts to promote esophageal cancer development. Cancer Cell. 2023;41(5):903\u2013918.e8.","journal-title":"Cancer Cell"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.02.009"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1411-0"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0323-0"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24271"},{"issue":"1","key":"e_1_3_2_134_2","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1038\/s41467-024-48649-8","article-title":"An improved epigenetic counter to track mitotic age in normal and precancerous tissues","volume":"15","author":"Zhu T","year":"2024","unstructured":"Zhu T, Tong H, Du Z, Beck S, Teschendorff AE. An improved epigenetic counter to track mitotic age in normal and precancerous tissues. Nat Commun. 2024;15(1):4211.","journal-title":"Nat Commun"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083557"},{"issue":"12","key":"e_1_3_2_136_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109722","article-title":"DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity","volume":"36","author":"Du Q","year":"2021","unstructured":"Du Q, Smith GC, Luu PL, Ferguson JM, Armstrong NJ, Caldon CE, Campbell EM, Nair SS, Zotenko E, Gould CM, et al. DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity. Cell Rep. 2021;36(12): Article 109722.","journal-title":"Cell Rep"},{"issue":"1","key":"e_1_3_2_137_2","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1038\/s41467-020-17227-z","article-title":"Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma","volume":"11","author":"Cao W","year":"2020","unstructured":"Cao W, Lee H, Wu W, Zaman A, McCorkle S, Yan M, Chen J, Xing Q, Sinnott-Armstrong N, Xu H, et al. Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma. Nat Commun. 2020;11(1):3675.","journal-title":"Nat Commun"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1645"},{"issue":"2","key":"e_1_3_2_139_2","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s12032-013-0784-4","article-title":"Promoter methylation status of MGMT, hMSH2, and hMLH1 and its relationship to corresponding protein expression and TP53 mutations in human esophageal squamous cell carcinoma","volume":"31","author":"Su Y","year":"2014","unstructured":"Su Y, Yin L, Liu R, Sheng J, Yang M, Wang Y, Pan E, Guo W, Pu Y, Zhang J, et al. Promoter methylation status of MGMT, hMSH2, and hMLH1 and its relationship to corresponding protein expression and TP53 mutations in human esophageal squamous cell carcinoma. Med Oncol. 2014;31(2):784.","journal-title":"Med Oncol"},{"issue":"1","key":"e_1_3_2_140_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ccell.2022.12.004","article-title":"Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma","volume":"41","author":"Liu Z","year":"2023","unstructured":"Liu Z, Zhao Y, Kong P, Liu Y, Huang J, Xu E, Wei W, Li G, Cheng X, Xue L, et al. Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma. Cancer Cell. 2023;41(1):181\u2013195.e9.","journal-title":"Cancer Cell"},{"issue":"1","key":"e_1_3_2_141_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13059-015-0644-y","article-title":"Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin","volume":"16","author":"Vandiver AR","year":"2015","unstructured":"Vandiver AR, Irizarry RA, Hansen KD, Garza LA, Runarsson A, Li X, Chien AL, Wang TS, Leung SG, Kang S, et al. Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin. Genome Biol. 2015;16(1):80.","journal-title":"Genome Biol"},{"issue":"1","key":"e_1_3_2_142_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41467-018-03025-1","article-title":"Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin","volume":"9","author":"Rodr\u00edguez-Paredes M","year":"2018","unstructured":"Rodr\u00edguez-Paredes M, Bormann F, Raddatz G, Gutekunst J, Lucena-Porcel C, K\u00f6hler F, Wurzer E, Schmidt K, Gallinat S, Wenck H, et al. Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin. Nat Commun. 2018;9(1):577.","journal-title":"Nat Commun"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170116"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-0269"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07328-w"},{"issue":"1","key":"e_1_3_2_146_2","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1038\/s41467-018-06081-9","article-title":"Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression","volume":"9","author":"Jiang Y","year":"2018","unstructured":"Jiang Y, Jiang Y-Y, Xie J-J, Mayakonda A, Hazawa M, Chen L, Xiao J-F, Li C-Q, Huang M-L, Ding L-W, et al. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nat Commun. 2018;9(1):3619.","journal-title":"Nat Commun"},{"issue":"1","key":"e_1_3_2_147_2","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.1038\/s41467-025-63754-y","article-title":"TP63 mediates the generation of tumour-specific chromatin loops that underlie MYC activation in radiation-induced tumorigenesis","volume":"16","author":"Liu Q","year":"2025","unstructured":"Liu Q, Jiang S, Xu X, Xu K, Luo Y, Yu Z, Xiang M, Xu Z, Wang L, Zhang S, et al. TP63 mediates the generation of tumour-specific chromatin loops that underlie MYC activation in radiation-induced tumorigenesis. Nat Commun. 2025;16(1):8718.","journal-title":"Nat Commun"},{"issue":"1","key":"e_1_3_2_148_2","doi-asserted-by":"crossref","first-page":"8190","DOI":"10.1038\/s41467-025-63591-z","article-title":"SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape","volume":"16","author":"Wang Z","year":"2025","unstructured":"Wang Z, Dai R, Kang L, Yang H, Chen Z, He J, Shu L, Zhong Y, Zhang Y, Hua Z, et al. SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape. Nat Commun. 2025;16(1):8190.","journal-title":"Nat Commun"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.053"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311818"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06682-5"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2015.1118537"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12456"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.066"},{"issue":"9","key":"e_1_3_2_155_2","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021795118","article-title":"Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation","volume":"118","author":"Rajagopalan KN","year":"2021","unstructured":"Rajagopalan KN, Chen X, Weinberg DN, Chen H, Majewski J, Allis CD, Lu C. Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation. Proc Natl Acad Sci USA. 2021;118(9): Article e2021795118.","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.09.007"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03170-y"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01498-5"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.03.006"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1763-5"},{"key":"e_1_3_2_161_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04116-8"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00350-6"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-016-2690-5"},{"key":"e_1_3_2_164_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2021.01.006"},{"issue":"1","key":"e_1_3_2_165_2","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1038\/s41467-023-39185-y","article-title":"Impaired histone inheritance promotes tumor progression","volume":"14","author":"Tian C","year":"2023","unstructured":"Tian C, Zhou J, Li X, Gao Y, Wen Q, Kang X, Wang N, Yao Y, Jiang J, Song G, et al. Impaired histone inheritance promotes tumor progression. Nat Commun. 2023;14(1):3429.","journal-title":"Nat Commun"},{"issue":"1","key":"e_1_3_2_166_2","doi-asserted-by":"crossref","DOI":"10.1080\/15592294.2025.2466382","article-title":"Normal bronchial field basal cells show persistent methylome-wide impact of tobacco smoking, including in known cancer genes","volume":"20","author":"Khulan B","year":"2025","unstructured":"Khulan B, Ye K, Shi MK, Waldman S, Marsh A, Siddiqui T, Okorozo A, Desai A, Patel D, Dobkin J, et al. Normal bronchial field basal cells show persistent methylome-wide impact of tobacco smoking, including in known cancer genes. Epigenetics. 2025;20(1): Article 2466382.","journal-title":"Epigenetics"},{"issue":"25","key":"e_1_3_2_167_2","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1038\/onc.2010.129","article-title":"Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate","volume":"29","author":"Liu F","year":"2010","unstructured":"Liu F, Killian JK, Yang M, Walker RL, Hong JA, Zhang M, Davis S, Zhang Y, Hussain M, Xi S, et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene. 2010;29(25):3650\u20133664.","journal-title":"Oncogene"},{"issue":"1","key":"e_1_3_2_168_2","doi-asserted-by":"crossref","DOI":"10.1080\/15592294.2023.2214392","article-title":"Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension","volume":"18","author":"Carreras-Gallo N","year":"2023","unstructured":"Carreras-Gallo N, Dwaraka VB, C\u00e1ceres A, Smith R, Mendez TL, Went H, Gonzalez JR. Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension. Epigenetics. 2023;18(1): Article 2214392.","journal-title":"Epigenetics"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2019.07.001"},{"issue":"10","key":"e_1_3_2_170_2","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1002\/ijc.25569","article-title":"Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma","volume":"128","author":"Huang Y","year":"2011","unstructured":"Huang Y, Chang X, Lee J, Cho YG, Zhong X, Park I-S, Liu J-W, Califano JA, Ratovitski EA, Sidransky D, et al. Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma. Int J Cancer. 2011;128(10):2261\u20132273.","journal-title":"Int J Cancer"},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717340115"},{"key":"e_1_3_2_172_2","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1032683","article-title":"Integrated analysis reveals common DNA methylation patterns of alcohol-associated cancers: A pan-cancer analysis","volume":"14","author":"Liu X","year":"2023","unstructured":"Liu X, Chen J, Li J, Zeng Z, Jiang X, Gao Y, Huang Z, Wu Q, Gong Y, Xie C. Integrated analysis reveals common DNA methylation patterns of alcohol-associated cancers: A pan-cancer analysis. Front Genet. 2023;14: Article 1032683.","journal-title":"Front Genet"},{"key":"e_1_3_2_173_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01120-0"},{"issue":"6792","key":"e_1_3_2_174_2","doi-asserted-by":"crossref","DOI":"10.1126\/science.adz6830","article-title":"Distinctive DNA sequence features define epigenetic longevity of inflammatory memory","volume":"391","author":"Cowley CJ","year":"2026","unstructured":"Cowley CJ, Sajjath SM, Soto-Ugaldi LF, Steiger M, Larsen SB, Carroll T, Barrows D, Mattei A, Gonzales KAU, Wang W, et al. Distinctive DNA sequence features define epigenetic longevity of inflammatory memory. Science. 2026;391(6792): Article eadz6830.","journal-title":"Science"},{"issue":"1","key":"e_1_3_2_175_2","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1038\/s41467-026-71996-7","article-title":"Histone methylation defines c-Jun\/Sox2\/Hif1\u03b1 axis that controls stemness and tumor progression in squamous cell carcinoma","volume":"17","author":"Mehta D","year":"2026","unstructured":"Mehta D, Paradkar A, Rekhi B, Nayak P, Mohanty B, Chaudhari P, Gera P, Rane S, Chaturvedi P, Waghmare SK. Histone methylation defines c-Jun\/Sox2\/Hif1\u03b1 axis that controls stemness and tumor progression in squamous cell carcinoma. Nat Commun. 2026;17(1):5753.","journal-title":"Nat Commun"},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-020-0265-5"},{"issue":"8","key":"e_1_3_2_177_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108769","article-title":"Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma","volume":"34","author":"Farhangdoost N","year":"2021","unstructured":"Farhangdoost N, Horth C, Hu B, Bareke E, Chen X, Li Y, Coradin M, Garcia BA, Lu C, Majewski J. Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma. Cell Rep. 2021;34(8): Article 108769.","journal-title":"Cell Rep"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.11.015"},{"key":"e_1_3_2_179_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00859-2"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-2446"},{"issue":"1","key":"e_1_3_2_181_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13148-020-0819-6","article-title":"Methylation silencing of TGF-\u03b2 receptor type II is involved in malignant transformation of esophageal squamous cell carcinoma","volume":"12","author":"Ma Y","year":"2020","unstructured":"Ma Y, He S, Gao A, Zhang Y, Zhu Q, Wang P, Yang B, Yin H, Li Y, Song J, et al. Methylation silencing of TGF-\u03b2 receptor type II is involved in malignant transformation of esophageal squamous cell carcinoma. Clin Epigenetics. 2020;12(1):25.","journal-title":"Clin Epigenetics"},{"key":"e_1_3_2_182_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06303-1"},{"issue":"9","key":"e_1_3_2_183_2","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1038\/s41591-021-01448-w","article-title":"Limited evolution of the actionable metastatic cancer genome under therapeutic pressure","volume":"27","author":"Haar J","year":"2021","unstructured":"van de Haar J, Hoes LR, Roepman P, Lolkema MP, Verheul HMW, Gelderblom H, de Langen AJ, Smit EF, Cuppen E, Wessels LFA, et al. Limited evolution of the actionable metastatic cancer genome under therapeutic pressure. Nat Med. 2021;27(9):1553\u20131563.","journal-title":"Nat Med"},{"issue":"1","key":"e_1_3_2_184_2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41467-017-00650-0","article-title":"Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing","volume":"8","author":"Chen X-X","year":"2017","unstructured":"Chen X-X, Zhong Q, Liu Y, Yan S-M, Chen Z-H, Jin S-Z, Xia T-L, Li R-Y, Zhou A-J, Su Z, et al. Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing. Nat Commun. 2017;8(1):524.","journal-title":"Nat Commun"},{"key":"e_1_3_2_185_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12601"},{"key":"e_1_3_2_186_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1330-0"},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.03.033"},{"issue":"9","key":"e_1_3_2_188_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.xcrm.2023.101168","article-title":"Absence of Lugol staining indicates initiation of esophageal squamous cell carcinoma: A combined genomic and epidemiologic study","volume":"4","author":"Liu Z","year":"2023","unstructured":"Liu Z, Liu M, Liu Y, Zhou R, Abliz A, Yuan W, Guo C, Zhang L, He W, Zheng H, et al. Absence of Lugol staining indicates initiation of esophageal squamous cell carcinoma: A combined genomic and epidemiologic study. Cell Rep Med. 2023;4(9): Article 101168.","journal-title":"Cell Rep Med"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-023-00660-9"},{"issue":"1","key":"e_1_3_2_190_2","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.1038\/s41467-023-41141-9","article-title":"Functionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinoma","volume":"14","author":"Sch\u00fctz S","year":"2023","unstructured":"Sch\u00fctz S, Sol\u00e9-Boldo L, Lucena-Porcel C, Hoffmann J, Brobeil A, Lonsdorf AS, Rodr\u00edguez-Paredes M, Lyko F. Functionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinoma. Nat Commun. 2023;14(1):5413.","journal-title":"Nat Commun"},{"issue":"19","key":"e_1_3_2_191_2","doi-asserted-by":"crossref","DOI":"10.1172\/JCI157649","article-title":"TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma","volume":"132","author":"Hu S","year":"2022","unstructured":"Hu S, Lu H, Xie W, Wang D, Shan Z, Xing X, Wang X-M, Fang J, Dong W, Dai W, et al. TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma. J Clin Invest. 2022;132(19): Article e157649.","journal-title":"J Clin Invest"},{"issue":"1","key":"e_1_3_2_192_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41421-023-00532-4","article-title":"Single-cell and spatial dissection of precancerous lesions underlying the initiation process of oral squamous cell carcinoma","volume":"9","author":"Sun L","year":"2023","unstructured":"Sun L, Kang X, Wang C, Wang R, Yang G, Jiang W, Wu Q, Wang Y, Wu Y, Gao J, et al. Single-cell and spatial dissection of precancerous lesions underlying the initiation process of oral squamous cell carcinoma. Cell Discov. 2023;9(1):28.","journal-title":"Cell Discov"},{"issue":"1","key":"e_1_3_2_193_2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41392-023-01710-2","article-title":"Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression","volume":"8","author":"Chen L","year":"2023","unstructured":"Chen L, Zhu S, Liu T, Zhao X, Xiang T, Hu X, Wu C, Lin D. Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression. Signal Transduct Target Ther. 2023;8(1):453.","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_3_2_194_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01570-0"},{"key":"e_1_3_2_195_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103459","article-title":"Dissecting the single-cell transcriptome network underlying esophagus non-malignant tissues and esophageal squamous cell carcinoma","volume":"69","author":"Chen Z","year":"2021","unstructured":"Chen Z, Zhao M, Liang J, Hu Z, Huang Y, Li M, Pang Y, Lu T, Sui Q, Zhan C, et al. Dissecting the single-cell transcriptome network underlying esophagus non-malignant tissues and esophageal squamous cell carcinoma. EBioMedicine. 2021;69: Article 103459.","journal-title":"EBioMedicine"},{"issue":"12","key":"e_1_3_2_196_2","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202306515","article-title":"Spatial transcriptomic and metabolomic landscapes of oral submucous fibrosis-derived oral squamous cell carcinoma and its tumor microenvironment","volume":"11","author":"Zhi Y","year":"2024","unstructured":"Zhi Y, Wang Q, Zi M, Zhang S, Ge J, Liu K, Lu L, Fan C, Yan Q, Shi L, et al. Spatial transcriptomic and metabolomic landscapes of oral submucous fibrosis-derived oral squamous cell carcinoma and its tumor microenvironment. Adv Sci. 2024;11(12): Article e2306515.","journal-title":"Adv Sci"},{"issue":"4","key":"e_1_3_2_197_2","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add8977","article-title":"Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression","volume":"9","author":"Liu C","year":"2023","unstructured":"Liu C, Zhang M, Yan X, Ni Y, Gong Y, Wang C, Zhang X, Wan L, Yang H, Ge C, et al. Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression. Sci Adv. 2023;9(4): Article eadd8977.","journal-title":"Sci Adv"},{"issue":"1","key":"e_1_3_2_198_2","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41467-023-36691-x","article-title":"Single-cell transcriptome profiling of the stepwise progression of head and neck cancer","volume":"14","author":"Choi J-H","year":"2023","unstructured":"Choi J-H, Lee B-S, Jang JY, Lee YS, Kim HJ, Roh J, Shin YS, Woo HG, Kim C-H. Single-cell transcriptome profiling of the stepwise progression of head and neck cancer. Nat Commun. 2023;14(1):1055.","journal-title":"Nat Commun"},{"issue":"1","key":"e_1_3_2_199_2","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1038\/s41467-024-46912-6","article-title":"Single cell deciphering of progression trajectories of the tumor ecosystem in head and neck cancer","volume":"15","author":"Liu ZL","year":"2024","unstructured":"Liu ZL, Meng XY, Bao RJ, Shen MY, Sun JJ, Chen WD, Liu F, He Y. Single cell deciphering of progression trajectories of the tumor ecosystem in head and neck cancer. Nat Commun. 2024;15(1):2595.","journal-title":"Nat Commun"},{"key":"e_1_3_2_200_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203486"},{"issue":"1","key":"e_1_3_2_201_2","doi-asserted-by":"crossref","first-page":"8609","DOI":"10.1038\/s41467-024-52981-4","article-title":"Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma","volume":"15","author":"Ge J","year":"2024","unstructured":"Ge J, Meng Y, Guo J, Chen P, Wang J, Shi L, Wang D, Qu H, Wu P, Fan C, et al. Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma. Nat Commun. 2024;15(1):8609.","journal-title":"Nat Commun"},{"issue":"1","key":"e_1_3_2_202_2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12943-019-1123-y","article-title":"A novel IFN\u03b1-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma","volume":"19","author":"Ma H","year":"2020","unstructured":"Ma H, Chang H, Yang W, Lu Y, Hu J, Jin S. A novel IFN\u03b1-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma. Mol Cancer. 2020;19(1):4.","journal-title":"Mol Cancer"},{"issue":"1","key":"e_1_3_2_203_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12943-024-02191-9","article-title":"Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response","volume":"24","author":"Jenkins BH","year":"2025","unstructured":"Jenkins BH, Tracy I, Rodrigues MFSD, Smith MJL, Martinez BR, Edmond M, Mahadevan S, Rao A, Zong H, Liu K, et al. Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response. Mol Cancer. 2025;24(1):3.","journal-title":"Mol Cancer"},{"issue":"1","key":"e_1_3_2_204_2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41698-024-00606-w","article-title":"Acquired resistance to immunotherapy and chemoradiation in MYC amplified head and neck cancer","volume":"8","author":"Cyberski TF","year":"2024","unstructured":"Cyberski TF, Singh A, Korzinkin M, Mishra V, Pun F, Shen L, Wing C, Cheng X, Baird B, Miao Y, et al. Acquired resistance to immunotherapy and chemoradiation in MYC amplified head and neck cancer. NPJ Precis Oncol. 2024;8(1):114.","journal-title":"NPJ Precis Oncol"},{"key":"e_1_3_2_205_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0340-z"},{"issue":"4","key":"e_1_3_2_206_2","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20240758","article-title":"The MLL3\/GRHL2 complex regulates malignant transformation and anti-tumor immunity in squamous cancer","volume":"222","author":"Nam C","year":"2025","unstructured":"Nam C, Huang G, Zheng Y, Zhao H, Pan Y, Hu B, Wenger T, Van HT, Xu L-Y, Li E-M, et al. The MLL3\/GRHL2 complex regulates malignant transformation and anti-tumor immunity in squamous cancer. J Exp Med. 2025;222(4): Article e20240758.","journal-title":"J Exp Med"},{"issue":"12","key":"e_1_3_2_207_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166552","article-title":"Novel epigenetic therapeutic strategies and targets in cancer","volume":"1868","author":"Babar Q","year":"2022","unstructured":"Babar Q, Saeed A, Tabish TA, Pricl S, Townley H, Thorat N. Novel epigenetic therapeutic strategies and targets in cancer. Biochim Biophys Acta Mol Basis Dis. 2022;1868(12): Article 166552.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"e_1_3_2_208_2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12943-024-01993-1","article-title":"DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinoma","volume":"23","author":"Liu Y","year":"2024","unstructured":"Liu Y, Sun Y, Yang J, Wu D, Yu S, Liu J, Hu T, Luo J, Zhou H. DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinoma. Mol Cancer. 2024;23(1):104.","journal-title":"Mol Cancer"},{"key":"e_1_3_2_209_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215899","article-title":"DNMT and EZH2 inhibitors synergize to activate therapeutic targets in hepatocellular carcinoma","volume":"548","author":"Zhang L","year":"2022","unstructured":"Zhang L, Li H-T, Shereda R, Lu Q, Weisenberger DJ, O\u2019Connell C, Machida K, An W, Lenz H-J, El-Khoueiry A, et al. DNMT and EZH2 inhibitors synergize to activate therapeutic targets in hepatocellular carcinoma. Cancer Lett. 2022;548: Article 215899.","journal-title":"Cancer Lett"},{"issue":"10","key":"e_1_3_2_210_2","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1158\/1078-0432.CCR-04-2135","article-title":"Approval summary: Azacitidine for treatment of myelodysplastic syndrome subtypes","volume":"11","author":"Kaminskas E","year":"2005","unstructured":"Kaminskas E, Farrell A, Abraham S, Baird A, Hsieh LS, Lee SL, Leighton JK, Patel H, Rahman A, Sridhara R, et al. Approval summary: Azacitidine for treatment of myelodysplastic syndrome subtypes. Clin Cancer Res. 2005;11(10):3604\u20133608.","journal-title":"Clin Cancer Res"},{"key":"e_1_3_2_211_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-024-02655-1"},{"key":"e_1_3_2_212_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.lungcan.2019.12.005","article-title":"Next-generation sequencing informs diagnosis and identifies unexpected therapeutic targets in lung squamous cell carcinomas","volume":"140","author":"Sands JM","year":"2020","unstructured":"Sands JM, Nguyen T, Shivdasani P, Sacher AG, Cheng ML, Alden RS, J\u00e4nne PA, Kuo FC, Oxnard GR, Sholl LM. Next-generation sequencing informs diagnosis and identifies unexpected therapeutic targets in lung squamous cell carcinomas. Lung Cancer. 2020;140:35\u201341.","journal-title":"Lung Cancer"},{"issue":"14","key":"e_1_3_2_213_2","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1097\/CM9.0000000000002832","article-title":"Genome-wide methylation profiling identified methylated KCNA3 and OTOP2 as promising diagnostic markers for esophageal squamous cell carcinoma","volume":"137","author":"Bian Y","year":"2024","unstructured":"Bian Y, Gao Y, Lu C, Tian B, Xin L, Lin H, Zhang Y, Zhang X, Zhou S, Wan K, et al. Genome-wide methylation profiling identified methylated KCNA3 and OTOP2 as promising diagnostic markers for esophageal squamous cell carcinoma. Chin Med J. 2024;137(14):1724\u20131735.","journal-title":"Chin Med J"},{"issue":"2","key":"e_1_3_2_214_2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1053\/j.gastro.2017.08.023","article-title":"Epidemiology of esophageal squamous cell carcinoma","volume":"154","author":"Abnet CC","year":"2018","unstructured":"Abnet CC, Arnold M, Wei W-Q. Epidemiology of esophageal squamous cell carcinoma. Gastroenterology. 2018;154(2):360\u2013373.","journal-title":"Gastroenterology"},{"key":"e_1_3_2_215_2","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-074962","article-title":"Advances in diagnosis and management of cancer of the esophagus","volume":"385","author":"Deboever N","year":"2024","unstructured":"Deboever N, Jones CM, Yamashita K, Ajani JA, Hofstetter WL. Advances in diagnosis and management of cancer of the esophagus. BMJ. 2024;385: Article e074962.","journal-title":"BMJ"},{"issue":"14","key":"e_1_3_2_216_2","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1200\/JCO.23.01284","article-title":"Effectiveness of endoscopic screening on esophageal cancer incidence and mortality: A 9-year report of the endoscopic screening for esophageal cancer in China (ESECC) randomized trial","volume":"42","author":"Liu M","year":"2024","unstructured":"Liu M, Yang W, Guo C, Liu Z, Li F, Liu A, Yang H, Shen L, Wu Q, Duan L, et al. Effectiveness of endoscopic screening on esophageal cancer incidence and mortality: A 9-year report of the endoscopic screening for esophageal cancer in China (ESECC) randomized trial. J Clin Oncol. 2024;42(14):1655\u20131664.","journal-title":"J Clin Oncol"},{"issue":"6586","key":"e_1_3_2_217_2","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay9040","article-title":"Early detection of cancer","volume":"375","author":"Crosby D","year":"2022","unstructured":"Crosby D, Bhatia S, Brindle KM, Coussens LM, Dive C, Emberton M, Esener S, Fitzgerald RC, Gambhir SS, Kuhn P, et al. Early detection of cancer. Science. 2022;375(6586): Article eaay9040.","journal-title":"Science"},{"issue":"1","key":"e_1_3_2_218_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13045-024-01565-2","article-title":"Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: A double-blinded, multicenter, prospective study","volume":"17","author":"Bian Y","year":"2024","unstructured":"Bian Y, Gao Y, Lin H, Sun C, Wang W, Sun S, Li X, Feng Z, Ren J, Chen H, et al. Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: A double-blinded, multicenter, prospective study. J Hematol Oncol. 2024;17(1):47.","journal-title":"J Hematol Oncol"},{"issue":"10","key":"e_1_3_2_219_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2024.102127","article-title":"Early diagnostic markers for esophageal squamous cell carcinoma: Copy number alteration gene identification and cfDNA detection","volume":"104","author":"Chen J","year":"2024","unstructured":"Chen J, Liu X, Zhang Z, Su R, Geng Y, Guo Y, Zhang Y, Su M. Early diagnostic markers for esophageal squamous cell carcinoma: Copy number alteration gene identification and cfDNA detection. Lab Investig. 2024;104(10): Article 102127.","journal-title":"Lab Investig"},{"issue":"1","key":"e_1_3_2_220_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12916-025-04066-2","article-title":"Machine learning technique-based four-autoantibody test for early detection of esophageal squamous cell carcinoma: A multicenter, retrospective study with a nested case-control study","volume":"23","author":"Xu Y-W","year":"2025","unstructured":"Xu Y-W, Peng Y-H, Liu C-T, Chen H, Chu L-Y, Chen H-L, Wu Z-Y, Wei W-Q, Xu L-Y, Wu F-C, et al. Machine learning technique-based four-autoantibody test for early detection of esophageal squamous cell carcinoma: A multicenter, retrospective study with a nested case-control study. BMC Med. 2025;23(1):235.","journal-title":"BMC Med"},{"key":"e_1_3_2_221_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2021.08.016"},{"issue":"7","key":"e_1_3_2_222_2","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1038\/s41591-023-02407-3","article-title":"Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer","volume":"29","author":"Serrano-Villar S","year":"2023","unstructured":"Serrano-Villar S, Tincati C, Raju SC, S\u00e1enz JS, Moreno E, Bargiela R, Cabello-Ubeda A, Sendagorta E, Kurz A, Perez Molina JA, et al. Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer. Nat Med. 2023;29(7):1738\u20131749.","journal-title":"Nat Med"},{"key":"e_1_3_2_223_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.06.021"},{"key":"e_1_3_2_224_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12542"},{"key":"e_1_3_2_225_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(24)00153-5"},{"issue":"5","key":"e_1_3_2_226_2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S2468-1253(23)00004-3","article-title":"Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: A nationwide, multicohort, prospective study","volume":"8","author":"Gao Y","year":"2023","unstructured":"Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou A-J, Huang S, Wang J-H, Feng Y-D, Yao S-H, et al. Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: A nationwide, multicohort, prospective study. Lancet Gastroenterol Hepatol. 2023;8(5):432\u2013445.","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"8","key":"e_1_3_2_227_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.xcrm.2024.101664","article-title":"Leveraging cfDNA fragmentomic features in a stacked ensemble model for early detection of esophageal squamous cell carcinoma","volume":"5","author":"Jiao Z","year":"2024","unstructured":"Jiao Z, Zhang X, Xuan Y, Shi X, Zhang Z, Yu A, Li N, Yang S, He X, Zhao G, et al. Leveraging cfDNA fragmentomic features in a stacked ensemble model for early detection of esophageal squamous cell carcinoma. Cell Rep Med. 2024;5(8): Article 101664.","journal-title":"Cell Rep Med"},{"issue":"1","key":"e_1_3_2_228_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S2468-1253(23)00276-5","article-title":"Effect of an artificial intelligence-assisted system on endoscopic diagnosis of superficial oesophageal squamous cell carcinoma and precancerous lesions: A multicentre, tandem, double-blind, randomised controlled trial","volume":"9","author":"Yuan X-L","year":"2024","unstructured":"Yuan X-L, Liu W, Lin Y-X, Deng Q-Y, Gao Y-P, Wan L, Zhang B, Zhang T, Zhang W-H, Bi X-G, et al. Effect of an artificial intelligence-assisted system on endoscopic diagnosis of superficial oesophageal squamous cell carcinoma and precancerous lesions: A multicentre, tandem, double-blind, randomised controlled trial. Lancet Gastroenterol Hepatol. 2024;9(1):34\u201344.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"e_1_3_2_229_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-023-00583-5"},{"issue":"7639","key":"e_1_3_2_230_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature21056","article-title":"Dermatologist-level classification of skin cancer with deep neural networks","volume":"542","author":"Esteva A","year":"2017","unstructured":"Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, Thrun S. Dermatologist-level classification of skin cancer with deep neural networks. Nature. 2017;542(7639):115\u2013118.","journal-title":"Nature"},{"issue":"1","key":"e_1_3_2_231_2","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1038\/s41467-024-47886-1","article-title":"Multimodal analysis of cfDNA methylomes for early detecting esophageal squamous cell carcinoma and precancerous lesions","volume":"15","author":"Liu J","year":"2024","unstructured":"Liu J, Dai L, Wang Q, Li C, Liu Z, Gong T, Xu H, Jia Z, Sun W, Wang X, et al. Multimodal analysis of cfDNA methylomes for early detecting esophageal squamous cell carcinoma and precancerous lesions. Nat Commun. 2024;15(1):3700.","journal-title":"Nat Commun"},{"issue":"1","key":"e_1_3_2_232_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41392-025-02342-4","article-title":"Signaling pathways and targeted interventions for precancers","volume":"11","author":"Yang J","year":"2026","unstructured":"Yang J, Wang S, Li X, Xu H, Sun T, Hu T, Luo J, Zhou H. Signaling pathways and targeted interventions for precancers. Signal Transduct Target Ther. 2026;11(1):9.","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_3_2_233_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2025.102611","article-title":"Precancerous microenvironment: A signalling perspective","volume":"98","author":"Qin X","year":"2026","unstructured":"Qin X. Precancerous microenvironment: A signalling perspective. Curr Opin Cell Biol. 2026;98: Article 102611.","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"e_1_3_2_234_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41420-024-01842-6","article-title":"NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma","volume":"10","author":"Topchu I","year":"2024","unstructured":"Topchu I, Bychkov I, Gursel D, Makhov P, Boumber Y. NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma. Cell Death Discov. 2024;10(1):75.","journal-title":"Cell Death Discov"}],"container-title":["Cancer Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.34133\/cancomm.0051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:02:07Z","timestamp":1792396927000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.34133\/cancomm.0051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":233,"alternative-id":["10.34133\/cancomm.0051"],"URL":"https:\/\/doi.org\/10.34133\/cancomm.0051","relation":{},"ISSN":["2523-3548"],"issn-type":[{"value":"2523-3548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"assertion":[{"value":"2026-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-25","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"0051"}}