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Myoelectric control provides an intuitive human\u2013robot interface by translating muscle activity into assistive commands. However, its practical application is still challenged by signal annotation, multijoint coordination, and cross-task generalization. This study proposes a 3-level intelligent framework for multijoint upper-limb assistance based on electromyography (EMG) to support the daily living activities of older adults. At the physiological level, situation-aware labeling protocols matched to different EMG conditions are proposed to reduce annotation ambiguity and improve robustness to signal changes. At the functional level, focusing on elemental joint activities, a deep backbone model is designed to infer both single-joint movements and coordinated multijoint patterns with an accuracy of 95.34%. At the behavioral level, the model is further distilled to support complex ADL tasks with human\u2013robot interactions while continually incorporating new knowledge without catastrophic forgetting. The framework is implemented in real time on an EMG-controlled multijoint robotic system, providing smooth and coordinated assistance in daily activities. Overall, the proposed framework provides a systematic solution for EMG-based multijoint coordination, encompassing the entire pathway from physiological signal processing to functional intent decoding and behavioral adaptation during daily activities. It offers a technical approach to coordinated upper-limb assistance and lays a broader foundation for the design of practical and adaptive assistive systems, contributing to improved autonomy for older adults and supporting the broader societal goal of healthy aging.<\/jats:p>","DOI":"10.34133\/cbsystems.0638","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T22:37:25Z","timestamp":1781476645000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Artificial-Intelligence-Driven Electromyography Adaptation for Elderly Assistance at Physiological, Functional, and Behavioral Levels"],"prefix":"10.34133","volume":"7","author":[{"given":"Jiaqi","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, \rCity University of Hong Kong, Hong Kong 999077, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \rCity University of Hong Kong, Hong Kong 999077, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \rCity University of Hong Kong, Hong Kong 999077, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijia","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \rCity University of Hong Kong, Hong Kong 999077, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \rCity University of Hong Kong, Hong Kong 999077, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin Pak Yu","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \rCity University of Hong Kong, Hong Kong 999077, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \rCity University of Hong Kong, Hong Kong 999077, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \rCity University of Hong Kong, Hong Kong 999077, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, \rCity University of Hong Kong, Hong Kong 999077, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clio Yuen Man","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Social Work &amp; 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