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J"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Highlights<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:label>\u2022<\/jats:label>\n                        <jats:p>\n                          Flavonoid\n                          <jats:bold>18ad<\/jats:bold>\n                          was identified as a promising androgen receptor antagonist.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:label>\u2022<\/jats:label>\n                        <jats:p>\n                          MD simulations and MM\/PB(GB)SA suggest the stability of the AR\u2013\n                          <jats:bold>18ad<\/jats:bold>\n                          complex.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:label>\u2022<\/jats:label>\n                        <jats:p>\n                          <jats:bold>18ad<\/jats:bold>\n                          selectively inhibits AR-dependent LNCaP cells over AR-independent PC-3 cells.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:label>\u2022<\/jats:label>\n                        <jats:p>\n                          <jats:bold>18ad<\/jats:bold>\n                          effectively down-regulates the AR\/PSA transcriptional signaling axis.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  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