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and artificial-intelligence-guided virtual screening (Virus-Like Particle Immunogenicity Modulation [VLPIM]) to pinpoint variants likely to regulate CD4\u207a T cell activation while preserving VLP integrity.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:label>\u2022<\/jats:label>\n                        <jats:p>\n                          <jats:bold>Applications:<\/jats:bold>\n                          Using the native hepatitis B virus capsid-derived VLP (HBc VLP) sequence and characteristics as inputs, VLPIM generated VLP variants that preserved the native virus-like morphology, while in vitro immunogenicity assays confirmed that epitope substitutions could either suppress or enhance CD4\u207a T cell activation.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:label>\u2022<\/jats:label>\n                        <jats:p>\n                          <jats:bold>Conclusion:<\/jats:bold>\n                          VLPIM permits precise immunogenicity modulation of VLPs and other multimers, facilitating their development as targeted drug carriers and next-generation vaccine platforms.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.34133\/csbj.0063","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:18:17Z","timestamp":1774923497000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Rational Immunogenicity Modulation of Virus-Like Particles by VLPIM"],"prefix":"10.34133","volume":"35","author":[{"given":"Chufan","family":"Wang","sequence":"first","affiliation":[{"name":"Research Center for Medicinal Structural Biology, National 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