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Because cell division is paced by progression through the cell cycle, cell-cycle control is the fundamental axis linking intracellular regulation to population-level dynamics. Quantitatively capturing how cell-cycle regulation affects population dynamics is thus central to understanding tissue homeostasis, tumor expansion, immune responses, and the performance of cell-based bioprocesses\u2014from tissue engineering and regenerative applications to the manufacturing of vaccines and recombinant therapeutics. In this view, a broad spectrum of mathematical models has been proposed to describe cell population dynamics, ranging from phenomenological growth laws that treat net proliferation as a black box to structured descriptions that resolve single-cell heterogeneity and link population change to cell-cycle progression. In this review, we survey deterministic frameworks for modeling cell-cycle-informed population dynamics, highlighting how modeling choices map onto accessible experimental readouts and biomedical and biotechnological questions. In doing so, we aim to provide a theoretical roadmap for readers new to the field who seek to translate intracellular cell-cycle regulation into empirically grounded population-level models. We organize models along 2 conceptual dimensions: the representation of cell-to-cell heterogeneity through increasing levels of population structure and the level of mechanistic specification of cell division through cell-cycle regulation. In particular, we discuss practical approaches to couple cell-cycle regulation to population-level dynamics\u2014from coarse-grained to explicit multiscale couplings\u2014and how external perturbations enter such couplings. We conclude by outlining open challenges toward cell-cycle-aware population models that match mechanistic resolution with experimental identifiability.<\/jats:p>","DOI":"10.34133\/csbj.0192","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:35:23Z","timestamp":1784543723000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Cell Population Dynamics Informed by Cell-Cycle Regulation: A Deterministic Modeling Toolkit"],"prefix":"10.34133","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8747-533X","authenticated-orcid":true,"given":"Elsi","family":"Ferro","sequence":"first","affiliation":[{"name":"CRS4 (Center for Advanced Studies, Research and Development in Sardinia), Pula","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-513X","authenticated-orcid":false,"given":"Antonio","family":"Laus","sequence":"additional","affiliation":[{"name":"CRS4 (Center for Advanced Studies, Research and Development in Sardinia), Pula","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0020-0013","authenticated-orcid":false,"given":"Rossano","family":"Atzeni","sequence":"additional","affiliation":[{"name":"CRS4 (Center for Advanced Studies, Research and Development in Sardinia), Pula","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-8621","authenticated-orcid":false,"given":"Maria","family":"Valentini","sequence":"additional","affiliation":[{"name":"CRS4 (Center for Advanced Studies, Research and Development in Sardinia), Pula","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4246-6963","authenticated-orcid":false,"given":"Enrico","family":"Pieroni","sequence":"additional","affiliation":[{"name":"CRS4 (Center for Advanced Studies, Research and Development in Sardinia), Pula","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Pisu","sequence":"additional","affiliation":[{"name":"CRS4 (Center for Advanced Studies, Research and Development in Sardinia), Pula","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"issue":"1","key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/PL00000780","article-title":"Regulation of G1 phase progression by growth factors and the extracellular matrix","volume":"58","author":"Hulleman E","year":"2001","unstructured":"Hulleman E, Boonstra J. 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