{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:16:13Z","timestamp":1788423373449,"version":"build-2803163510"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"1","funder":[{"DOI":"10.13039\/501100023181","name":"Agencja Bada\u0144 Medycznych","doi-asserted-by":"publisher","award":["2023\/ABM\/02\/00008"],"award-info":[{"award-number":["2023\/ABM\/02\/00008"]}],"id":[{"id":"10.13039\/501100023181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023181","name":"Agencja Bada\u0144 Medycznych","doi-asserted-by":"publisher","award":["2023\/ABM\/02\/00008"],"award-info":[{"award-number":["2023\/ABM\/02\/00008"]}],"id":[{"id":"10.13039\/501100023181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Highlights<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:label>\u2022<\/jats:label>\n                        <jats:p>Integrated oral microbiome\u2013metabolome profiling in ALMS\/BBS<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:label>\u2022<\/jats:label>\n                        <jats:p>Disease-specific oral microbial restructuring beyond obesity<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:label>\u2022<\/jats:label>\n                        <jats:p>Distinct saliva and GCF microbiome\u2013metabolome networks<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:label>\u2022<\/jats:label>\n                        <jats:p>Organic, amino acid, and carbohydrate metabolism are associated with oral taxa<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:label>\u2022<\/jats:label>\n                        <jats:p>Multi-omics reveals functional host\u2013microbiome interactions<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.34133\/csbj.0211","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:03:50Z","timestamp":1786629830000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Oral Microbiome and Metabolome Profiling Identifies Disease-Associated Multi-Omics Signatures in Alstr\u00f6m and Bardet\u2013Biedl Syndromes"],"prefix":"10.34133","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2879-9710","authenticated-orcid":true,"given":"Patrycja","family":"Mojsak","sequence":"first","affiliation":[{"name":"Clinical Research Centre, \rMedical University of Bialystok, Bialystok, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8959-5757","authenticated-orcid":false,"given":"Ewa","family":"Zmyslowska-Polakowska","sequence":"additional","affiliation":[{"name":"Department of Endodontics, \rMedical University of Lodz, Lodz, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2286-7444","authenticated-orcid":false,"given":"Sandra","family":"Chmielewska","sequence":"additional","affiliation":[{"name":"Clinical Research Centre, \rMedical University of Bialystok, Bialystok, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8862-1767","authenticated-orcid":false,"given":"Krzysztof","family":"So\u0142owiej","sequence":"additional","affiliation":[{"name":"Clinical Research Centre, \rMedical University of Bialystok, Bialystok, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-278X","authenticated-orcid":false,"given":"Tomasz","family":"Ploszaj","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, \rMedical University of Lodz, Lodz, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2760-2397","authenticated-orcid":false,"given":"Sebastian","family":"Skoczylas","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, \rMedical University of Lodz, Lodz, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8779-3907","authenticated-orcid":false,"given":"Julia","family":"Grzybowska-Adamowicz","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, \rMedical University of Lodz, Lodz, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3169-1233","authenticated-orcid":false,"given":"Tomasz","family":"Pienkowski","sequence":"additional","affiliation":[{"name":"Clinical Research Centre, \rMedical University of Bialystok, Bialystok, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-4978","authenticated-orcid":false,"given":"Adam","family":"Kretowski","sequence":"additional","affiliation":[{"name":"Clinical Research Centre, \rMedical University of Bialystok, Bialystok, Poland."},{"name":"Department of Endocrinology, Diabetology and Internal Medicine, \rMedical University of Bialystok, Bialystok, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-4469","authenticated-orcid":false,"given":"Agnieszka","family":"Zmyslowska","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, \rMedical University of Lodz, Lodz, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3729-0518","authenticated-orcid":false,"given":"Michal","family":"Ciborowski","sequence":"additional","affiliation":[{"name":"Clinical Research Centre, \rMedical University of Bialystok, Bialystok, Poland."},{"name":"Department of Medical Biochemistry, \rMedical University of Bialystok, Bialystok, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"issue":"3","key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2174\/138920211795677912","article-title":"Alstr\u00f6m syndrome: Genetics and clinical overview","volume":"12","author":"Marshall JD","year":"2011","unstructured":"Marshall JD, Maffei P, Collin GB, Naggert JK. Alstr\u00f6m syndrome: Genetics and clinical overview. Curr Genomics. 2011;12(3):225\u2013235.","journal-title":"Curr Genomics"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1016\/j.csbj.2025.10.040","article-title":"Multi-matrix metabolomics in rare monogenic diabetes syndromes: Analysis of oral fluids and serum in carriers of pathogenic variants in the","volume":"27","author":"Zmys\u0142owska-Polakowska E","year":"2025","unstructured":"Zmys\u0142owska-Polakowska E, Mojsak P, Skoczylas S, So\u0142owiej K, Chmielewska S, Grzybowska-Adamowicz J, Palatynska-Ulatowska A, Lukomska-Szymanska M, Kretowski A, Zmys\u0142owska A, et al. Multi-matrix metabolomics in rare monogenic diabetes syndromes: Analysis of oral fluids and serum in carriers of pathogenic variants in the. Comput Struct Biotechnol J. 2025;27:4880\u20134889.","journal-title":"Comput Struct Biotechnol J"},{"issue":"4","key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.5582\/irdr.2021.01113","article-title":"A review of Alstr\u00f6m syndrome: A rare monogenic ciliopathy","volume":"10","author":"Choudhury AR","year":"2021","unstructured":"Choudhury AR, Munonye I, Sanu KP, Islam N, Gadaga C. A review of Alstr\u00f6m syndrome: A rare monogenic ciliopathy. Intractable Rare Dis Res. 2021;10(4):257\u2013262.","journal-title":"Intractable Rare Dis Res"},{"issue":"2","key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/cge.13768","article-title":"High prevalence of Bardet-Biedl syndrome in La R\u00e9union Island is due to a founder variant in ARL6\/BBS3","volume":"98","author":"Gouronc A","year":"2020","unstructured":"Gouronc A, Zilliox V, Jacquemont ML, Darcel F, Leuvrey AS, Nourisson E, Antin M, Alessandri JL, Doray B, Gueguen P, et al. High prevalence of Bardet-Biedl syndrome in La R\u00e9union Island is due to a founder variant in ARL6\/BBS3. Clin Genet. 2020;98(2):166\u2013171.","journal-title":"Clin Genet"},{"issue":"1","key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12937-023-00856-7","article-title":"The role of the oral microbiome in obesity and metabolic disease: Potential systemic implications and effects on taste perception","volume":"22","author":"Schamarek I","year":"2023","unstructured":"Schamarek I, Anders L, Chakaroun RM, Kovacs P, Rohde-Zimmermann K. The role of the oral microbiome in obesity and metabolic disease: Potential systemic implications and effects on taste perception. Nutr J. 2023;22(1):28.","journal-title":"Nutr J"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1630828","article-title":"Oral microbiome contributions to metabolic syndrome pathogenesis","volume":"16","author":"Yue Z","year":"2025","unstructured":"Yue Z, Fan Y, Shan G, Chen X. Oral microbiome contributions to metabolic syndrome pathogenesis. Front Microbiol. 2025;16: Article 1630828.","journal-title":"Front Microbiol"},{"issue":"7","key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1111\/odi.15220","article-title":"Integrated analysis of oral microbiome and metabolome in T2DM patients with varying glycemic status","volume":"31","author":"Diao J","year":"2025","unstructured":"Diao J, Zhang Y, Zhang X, Jia S, Lei Y, Ma B, Li X, Zheng S, Yuan C. Integrated analysis of oral microbiome and metabolome in T2DM patients with varying glycemic status. Oral Dis. 2025;31(7):2308\u20132322.","journal-title":"Oral Dis"},{"issue":"11","key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.3390\/microorganisms13112442","article-title":"Evaluation of the oral microbiome in patients with Alstr\u00f6m and Bardet-Biedl syndromes and their heterozygous family members","volume":"13","author":"Zmys\u0142owska-Polakowska E","year":"2025","unstructured":"Zmys\u0142owska-Polakowska E, P\u0142oszaj T, Skoczylas S, Grzybowska-Adamowicz J, Palaty\u0144ska-Ulatowska A, \u0141ukomska-Szyma\u0144ska M, Zmys\u0142owska A. Evaluation of the oral microbiome in patients with Alstr\u00f6m and Bardet-Biedl syndromes and their heterozygous family members. Microorganisms. 2025;13(11):2442.","journal-title":"Microorganisms"},{"issue":"2","key":"e_1_3_4_10_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116819","article-title":"Integrative multi-omics analysis reveals oral microbiome-metabolome signatures of obesity","volume":"45","author":"Shibl AA","year":"2026","unstructured":"Shibl AA, Denekew TW, Ahmad AR, Abdelrazig S, Leonor CE, Utenova L, Zhang G, AbdelBaqi M, Malla Y, Arshad M, et al. Integrative multi-omics analysis reveals oral microbiome-metabolome signatures of obesity. Cell Rep. 2026;45(2): Article 116819.","journal-title":"Cell Rep"},{"issue":"3","key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/jre.12432","article-title":"Association of oral microbiome with type 2 diabetes risk","volume":"52","author":"Long J","year":"2017","unstructured":"Long J, Cai Q, Steinwandel M, Hargreaves MK, Bordenstein SR, Blot WJ, Zheng W, Shu XO. Association of oral microbiome with type 2 diabetes risk. J Periodontal Res. 2017;52(3):636\u2013643.","journal-title":"J Periodontal Res"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108278","article-title":"Identification of hyperglycemia-associated microbiota alterations in saliva and gingival sulcus","volume":"682","author":"Wei Y-S","year":"2020","unstructured":"Wei Y-S, Hsiao Y-C, Su G-W, Chang Y-R, Lin H-P, Wang Y-S, Tsai Y-T, Liao E-C, Chen H-Y, Chou H-C, et al. Identification of hyperglycemia-associated microbiota alterations in saliva and gingival sulcus. Arch Biochem Biophys. 2020;682: Article 108278.","journal-title":"Arch Biochem Biophys"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.2147\/DMSO.S477494","article-title":"Alterations in the gut microbiota composition in obesity with and without type 2 diabetes: A pilot study","volume":"17","author":"Wang X","year":"2024","unstructured":"Wang X, Guo Q, Liu Z, Wang Y, Cao C, Jin L, Li C, Xiao J, Zhao W. Alterations in the gut microbiota composition in obesity with and without type 2 diabetes: A pilot study. Diabetes Metab Syndr Obes. 2024;17:3965\u20133974.","journal-title":"Diabetes Metab Syndr Obes"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-00904-4"},{"issue":"1","key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s00018-025-05889-1","article-title":"Microbial dysbiosis in oral cavity determines obesity status in adolescents","volume":"82","author":"Malik MZ","year":"2025","unstructured":"Malik MZ, Nizam R, Jacob S, Al Alqaderi H, Al-Mulla F, Alqaderi H. Microbial dysbiosis in oral cavity determines obesity status in adolescents. Cell Mol Life Sci. 2025;82(1):354.","journal-title":"Cell Mol Life Sci"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0089-x"},{"issue":"25","key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1016\/j.jacc.2016.09.972","article-title":"The emerging role of metabolomics in the diagnosis and prognosis of cardiovascular disease","volume":"68","author":"Ussher JR","year":"2016","unstructured":"Ussher JR, Elmariah S, Gerszten RE, Dyck JR. The emerging role of metabolomics in the diagnosis and prognosis of cardiovascular disease. J Am Coll Cardiol. 2016;68(25):2850\u20132870.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1607845","article-title":"Integrated oral microbiome and metabolome analysis unveils key biomarkers and functional pathway alterations in patients with acute myocardial infarction","volume":"15","author":"Khan I","year":"2025","unstructured":"Khan I, Irfan M, Ping X, Xiaohui Y, Lei S, Song T, Xie X, Li Z. Integrated oral microbiome and metabolome analysis unveils key biomarkers and functional pathway alterations in patients with acute myocardial infarction. Front Cell Infect Microbiol. 2025;15: Article 1607845.","journal-title":"Front Cell Infect Microbiol"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2025.11.043"},{"issue":"1","key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12903-023-02722-8","article-title":"Salivary microbiome and metabolome analysis of severe early childhood caries","volume":"23","author":"Li K","year":"2023","unstructured":"Li K, Wang J, Du N, Sun Y, Sun Q, Yin W, Li H, Meng L, Liu X. Salivary microbiome and metabolome analysis of severe early childhood caries. BMC Oral Health. 2023;23(1):30.","journal-title":"BMC Oral Health"},{"issue":"11","key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1177\/0022034511416240","article-title":"Metabolomics reveals elevated macromolecular degradation in periodontal disease","volume":"90","author":"Barnes VM","year":"2011","unstructured":"Barnes VM, Ciancio SG, Shibly O, Xu T, Devizio W, Trivedi HM, Guo L, J\u00f6nsson TJ. Metabolomics reveals elevated macromolecular degradation in periodontal disease. J Dent Res. 2011;90(11):1293\u20131297.","journal-title":"J Dent Res"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7544864","article-title":"Salivary metabolomics of well and poorly controlled type 1 and type 2 diabetes","volume":"2022","author":"Bencharit S","year":"2022","unstructured":"Bencharit S, Carlson J, Byrd WC, Howard-Williams EL, Seagroves JT, McRitchie S, Buse JB, Sumner S. Salivary metabolomics of well and poorly controlled type 1 and type 2 diabetes. Int J Dent. 2022;2022: Article 7544864.","journal-title":"Int J Dent"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2019.11.051","article-title":"Role of gut microbiota in type 2 diabetes pathophysiology","volume":"51","author":"Gurung M","year":"2020","unstructured":"Gurung M, Li Z, You H, Rodrigues R, Jump DB, Morgun A, Shulzhenko N. Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine. 2020;51: Article 102590.","journal-title":"EBioMedicine"},{"issue":"1","key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/jcpe.13566","article-title":"The microbiome of dental and peri-implant subgingival plaque during peri-implant mucositis therapy: A randomized clinical trial","volume":"49","author":"Philip J","year":"2022","unstructured":"Philip J, Buijs MJ, Pappalardo VY, Crielaard W, Brandt BW, Zaura E. The microbiome of dental and peri-implant subgingival plaque during peri-implant mucositis therapy: A randomized clinical trial. J Clin Periodontol. 2022;49(1):28\u201338.","journal-title":"J Clin Periodontol"},{"issue":"20","key":"e_1_3_4_25_2","first-page":"S44","article-title":"Plaque-induced gingivitis: Case definition and diagnostic considerations","volume":"45","author":"Trombelli L","year":"2018","unstructured":"Trombelli L, Farina R, Silva CO, Tatakis DN. Plaque-induced gingivitis: Case definition and diagnostic considerations. J Clin Periodontol. 2018;45(Suppl 20):S44\u2013S67.","journal-title":"J Clin Periodontol"},{"issue":"1","key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1186\/s12903-024-04677-w","article-title":"Analysis of the microbial community diversity in various regions of the healthy oral cavity","volume":"24","author":"Liu Y","year":"2024","unstructured":"Liu Y, Qiao F, Wang Z, Meng G, Gu Y, Wu H, Liu D, Niu K. Analysis of the microbial community diversity in various regions of the healthy oral cavity. BMC Oral Health. 2024;24(1):978.","journal-title":"BMC Oral Health"},{"issue":"3","key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.3390\/ijerph20032252","article-title":"Oral microbiota\u2014One habitat or diverse niches? A pilot study of sampling and identification of oral bacterial and fungal biota in patients with type I diabetes mellitus treated with insulin pump","volume":"20","author":"Gregorczyk-Maga I","year":"2023","unstructured":"Gregorczyk-Maga I, Fiema M, Kania M, Jachowicz-Matczak E, Romaniszyn D, Gerreth K, Klupa T, W\u00f3jkowska-Mach J. Oral microbiota\u2014One habitat or diverse niches? A pilot study of sampling and identification of oral bacterial and fungal biota in patients with type I diabetes mellitus treated with insulin pump. Int J Environ Res Public Health. 2023;20(3):2252.","journal-title":"Int J Environ Res Public Health"},{"issue":"5","key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/odi.13313","article-title":"Inflammatory mediators in saliva and gingival fluid of children with congenital heart defect","volume":"26","author":"Mohamed Ali H","year":"2020","unstructured":"Mohamed Ali H, Mustafa M, Suliman S, Elshazali OH, Ali RW, Berggreen E. Inflammatory mediators in saliva and gingival fluid of children with congenital heart defect. Oral Dis. 2020;26(5):1053\u20131061.","journal-title":"Oral Dis"},{"issue":"17","key":"e_1_3_4_29_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e37609","article-title":"The complex link between the gut microbiome and obesity-associated metabolic disorders: Mechanisms and therapeutic opportunities","volume":"10","author":"Zhang K","year":"2024","unstructured":"Zhang K, Zhang Q, Qiu H, Ma Y, Hou N, Zhang J, Kan C, Han F, Sun X, Shi J. The complex link between the gut microbiome and obesity-associated metabolic disorders: Mechanisms and therapeutic opportunities. Heliyon. 2024;10(17): Article e37609.","journal-title":"Heliyon"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1633029","article-title":"The role of gut microbiota in insulin resistance: Recent progress","volume":"16","author":"Ji H","year":"2025","unstructured":"Ji H, Su S, Chen M, Liu S, Liu S, Guo J. The role of gut microbiota in insulin resistance: Recent progress. Front Microbiol. 2025;16: Article 1633029.","journal-title":"Front Microbiol"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15060397"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.4458","article-title":"Characterization of the salivary microbiome in people with obesity","volume":"6","author":"Wu Y","year":"2018","unstructured":"Wu Y, Chi X, Zhang Q, Chen F, Deng X. Characterization of the salivary microbiome in people with obesity. PeerJ. 2018;6: Article e4458.","journal-title":"PeerJ"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12223-014-0342-2"},{"issue":"20","key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.3390\/nu17203265","article-title":"Gut microbiota \u03b1-and \u03b2-diversity, but not dietary patterns, differ between underweight and normal-weight Japanese women aged 20\u201339 years","volume":"17","author":"Yamamoto-Wada R","year":"2025","unstructured":"Yamamoto-Wada R, Hiraiwa E, Okuma K, Yamada M, Ushiroda C, Deguchi K, Naruse H, Masuyama H, Iizuka K. Gut microbiota \u03b1-and \u03b2-diversity, but not dietary patterns, differ between underweight and normal-weight Japanese women aged 20\u201339 years. Nutrients. 2025;17(20):3265.","journal-title":"Nutrients"},{"issue":"14","key":"e_1_3_4_35_2","first-page":"S51","article-title":"Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases","volume":"40","author":"Schenkein HA","year":"2013","unstructured":"Schenkein HA, Loos BG. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. J Clin Periodontol. 2013;40(Suppl 14):S51\u2013S69.","journal-title":"J Clin Periodontol"},{"issue":"6","key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/jre.12474","article-title":"Oral application of a periodontal pathogen impacts SerpinE1 expression and pancreatic islet architecture in prediabetes","volume":"52","author":"Ilievski V","year":"2017","unstructured":"Ilievski V, Bhat UG, Suleiman-Ata S, Bauer BA, Toth PT, Olson ST, Unterman TG, Watanabe K. Oral application of a periodontal pathogen impacts SerpinE1 expression and pancreatic islet architecture in prediabetes. J Periodontal Res. 2017;52(6):1032\u20131041.","journal-title":"J Periodontal Res"},{"issue":"1","key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/prd.12162","article-title":"Reliability of periodontal diagnostic tools for monitoring peri-implant health and disease","volume":"73","author":"Coli P","year":"2017","unstructured":"Coli P, Christiaens V, Sennerby L, Bruyn HD. Reliability of periodontal diagnostic tools for monitoring peri-implant health and disease. Periodontol 2000. 2017;73(1):203\u2013217.","journal-title":"Periodontol 2000"},{"issue":"11","key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1093\/bioinformatics\/btaa188","article-title":"M2IA: A web server for microbiome and metabolome integrative analysis","volume":"36","author":"Ni Y","year":"2020","unstructured":"Ni Y, Yu G, Chen H, Deng Y, Wells PM, Steves CJ, Ju F, Fu J. M2IA: A web server for microbiome and metabolome integrative analysis. Bioinformatics. 2020;36(11):3493\u20133498.","journal-title":"Bioinformatics"},{"issue":"6","key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/jcpe.12900","article-title":"Validation of multivariable models for predicting tooth loss in periodontitis patients","volume":"45","author":"Schwendicke F","year":"2018","unstructured":"Schwendicke F, Schmietendorf E, Plaumann A, S\u00e4lzer S, D\u00f6rfer CE, Graetz C. Validation of multivariable models for predicting tooth loss in periodontitis patients. J Clin Periodontol. 2018;45(6):701\u2013710.","journal-title":"J Clin Periodontol"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05296-0"},{"issue":"9","key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1128\/AEM.00196-12","article-title":"Establishment of a tractable genetic transformation system in Veillonella spp","volume":"78","author":"Liu J","year":"2012","unstructured":"Liu J, Xie Z, Merritt J, Qi F. Establishment of a tractable genetic transformation system in Veillonella spp. Appl Environ Microbiol. 2012;78(9):3488\u20133491.","journal-title":"Appl Environ Microbiol"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114966"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.34133\/csbj.0211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:01:28Z","timestamp":1788422488000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.34133\/csbj.0211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3,1]]}},"alternative-id":["10.34133\/csbj.0211"],"URL":"https:\/\/doi.org\/10.34133\/csbj.0211","relation":{},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,1]]},"assertion":[{"value":"2026-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"0211"}}