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Current therapeutic approaches primarily target individual aspects of these changes, often failing to address the dual nature of facial adipose remodeling. Using a combination of in\u00a0vivo and ex\u00a0vivo methods, we present a therapeutic strategy based on\n                    <jats:italic toggle=\"yes\">Kaempferia parviflora<\/jats:italic>\n                    root extract (KPRE) rich in polymethoxyflavonoids. Mechanistically, we demonstrate that KPRE sustains preadipocyte proliferation while reducing hypertrophy in mature adipocytes via activation of the transcriptional regulators SOX9 and GATA3 while suppressing PPAR\u03b3 and SREBP1. To translate these findings toward human application, we conducted a clinical pilot study in 35 participants with topical application of KPRE long-chain fatty acid emulsions for 6 months. By comparing high-resolution stereoscopic imaging and digital 3-dimensional modeling data at baseline and after 3 months and 6 months of follow-up, we show significant volume restoration in atrophic regions and reduction in hypertrophic areas, consistent with the coordinated effects observed in the organotypic adipose culture models. These findings provide a successful example for the rapid translation of molecular insights gained from organotypic human tissue models to human application and provide clinical evidence supporting the potential of KPRE-based formulations for facial adipose tissue rejuvenation.\n                  <\/jats:p>","DOI":"10.34133\/csbj.0213","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:08:26Z","timestamp":1786698506000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Dual Modulation of Adipogenesis and Lipolysis Augments Facial Adipose Tissue Restoration"],"prefix":"10.34133","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0707-278X","authenticated-orcid":true,"given":"Nayere","family":"Taebnia","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology and Center for Molecular Medicine, \rKarolinska Institutet and University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9777-2899","authenticated-orcid":false,"given":"Magdalena","family":"Murawska","sequence":"additional","affiliation":[{"name":"ABS Group Inc.","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurino M.","family":"Kemas","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology and Center for Molecular Medicine, \rKarolinska Institutet and University Hospital, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongda","family":"Sheng","sequence":"additional","affiliation":[{"name":"Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, \rZhejiang University, Hangzhou 310058, China."},{"name":"State Key Laboratory of Chinese Medicine Modernization, Innovation Center of Yangtze River Delta, \rZhejiang University, 314102 Jiaxing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, \rZhejiang University, Hangzhou 310058, China."},{"name":"State Key Laboratory of Chinese Medicine Modernization, Innovation Center of Yangtze River Delta, \rZhejiang University, 314102 Jiaxing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0890-8665","authenticated-orcid":false,"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, \rHangzhou Third People\u2019s Hospital, Hangzhou, Zhejiang Province 310009, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanghai Hepo Biotechnology Co., Ltd","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-9552","authenticated-orcid":false,"given":"Ivan","family":"Galanin","sequence":"additional","affiliation":[{"name":"Adipeau Inc.","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-6204","authenticated-orcid":true,"given":"Volker M.","family":"Lauschke","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology and Center for Molecular Medicine, \rKarolinska Institutet and University Hospital, Stockholm, Sweden."},{"name":"Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology","place":["Germany"]},{"name":"University of T\u00fcbingen","place":["Germany"]},{"name":"Department of Pharmacy, the Second Xiangya Hospital, \rCentral South University, Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"issue":"10","key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/asj\/sjaa339","article-title":"The facial aging process from the \u201cinside out\u201d","volume":"41","author":"Swift A","year":"2020","unstructured":"Swift A, Liew S, Weinkle S, Garcia JK, Silberberg MB. 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