{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:46:15Z","timestamp":1787319975545,"version":"build-2736575974"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Research"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Periodontal lesions are common and frustrating diseases that impact life quality. Efforts in this aspect aim at developing local drug delivery systems with better efficacy and less toxicity. Herein, inspired by the sting separation behavior of bees, we conduct novel reactive oxygen species (ROS)-responsive detachable microneedles (MNs) that carry antibiotic metronidazole (Met) for controllable periodontal drug delivery and periodontitis treatment. Benefiting from the needle-base separation ability, such MNs can penetrate through the healthy gingival to reach the gingival sulcus's bottom while offering minimal impact to oral function. Besides, as the drug-encapsulated cores were protected by poly (lactic-co-glycolic acid) (PLGA) shells in MNs, the surrounding normal gingival tissue is not affected by Met, resulting in excellent local biosafety. Additionally, with the ROS-responsive PLGA-thioketal-polyethylene glycol MN tips, they can be unlocked to release Met directly around the pathogen under the high ROS in the periodontitis sulcus, bringing about improved therapeutic effects. Based on these characteristics, the proposed bioinspired MNs show good therapeutic results in treating a rat model with periodontitis, implying their potential in periodontal disease.<\/jats:p>","DOI":"10.34133\/research.0119","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T05:23:32Z","timestamp":1679981012000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":45,"title":["Bee Sting-Inspired Inflammation-Responsive Microneedles for Periodontal Disease Treatment"],"prefix":"10.34133","volume":"6","author":[{"given":"Chuanhui","family":"Song","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210002, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhui","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210002, China."},{"name":"State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China."},{"name":"Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2021.11.017"},{"issue":"1","key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/prd.12463","article-title":"Concise evaluation and therapeutic guidelines for severe periodontitis: A public health perspective","volume":"90","author":"Slots J","year":"2022","unstructured":"Slots J. 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NIR responsive nitric oxide nanogenerator for enhanced biofilm eradication and inflammation immunotherapy against periodontal diseases. Nano Today. 2022;43.","journal-title":"Nano Today"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.bioactmat.2021.07.033","article-title":"Photothermal therapy with regulated Nrf2\/NF-\u03baB signaling pathway for treating bacteria-induced periodontitis","volume":"9","author":"Tian Y","year":"2021","unstructured":"Tian Y, Li Y, Liu J, Lin Y, Jiao J, Chen B, Wang W, Wu S, Li C. Photothermal therapy with regulated Nrf2\/NF-\u03baB signaling pathway for treating bacteria-induced periodontitis. 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