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Through a facile microfluidic bioprinting strategy, a traditional Chinese herbal medicine (<jats:italic>Panax notoginseng<\/jats:italic>saponins [PNS]) and a living autotrophic microorganism (microalgae<jats:italic>Chlorella pyrenoidosa<\/jats:italic>[MA]) were successfully encapsulated into the scaffolds. The encapsulated PNS could be gradually released from the scaffolds, which promoted cell adhesion, proliferation, migration, and tube formation in\u00a0vitro. In addition, benefiting from the photosynthetic oxygenation of the alive MA, the obtained scaffolds would produce sustainable oxygen under light illumination, exerting a protective effect against hypoxia-induced cell death. Based on these features, we have demonstrated through in\u00a0vivo experiments that these living Chinese herbal scaffolds could efficiently alleviate local hypoxia, enhance angiogenesis, and thereby accelerate wound closure in diabetic mice, indicating their great potential in wound healing and other tissue repair applications.<\/jats:p>","DOI":"10.34133\/research.0138","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T15:49:17Z","timestamp":1682092157000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":34,"title":["Living Chinese Herbal Scaffolds from Microfluidic Bioprinting for Wound Healing"],"prefix":"10.34133","volume":"6","author":[{"given":"Xiaocheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China."},{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxuan","family":"Jia","sequence":"additional","affiliation":[{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Niu","sequence":"additional","affiliation":[{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhao","family":"Li","sequence":"additional","affiliation":[{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China."},{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China."},{"name":"State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China."},{"name":"Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe4839"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00905-2"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw3963"},{"issue":"35","key":"e_1_3_4_5_2","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj0153","article-title":"Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation","volume":"7","author":"Guan Y","year":"2021","unstructured":"Guan Y, Niu H, Liu Z, Dang Y, Shen J, Zayed M, Ma L, Guan J. 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