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Here, we prepare a F\u00f6rster resonance energy transfer-based ratiometric NIR-II window hydrogen sulfide (H\n            <jats:sub>2<\/jats:sub>\n            S) sensor through the combination of an H\n            <jats:sub>2<\/jats:sub>\n            S-responsive NIR-II cyanine dye (acceptor, LET-1055) and an H\n            <jats:sub>2<\/jats:sub>\n            S-inert rhodamine hybrid polymethine dye (donor, Rh930). This sensor not only exhibits high sensitivity and selectivity, but also shows rapid reaction kinetics (~20 min) and relatively low limit of detection (~96 nM) toward H\n            <jats:sub>2<\/jats:sub>\n            S, allowing in\u00a0vivo ratiometric NIR-II fluorescence imaging of orthotopic liver and colon tumors and visualization of the drug-induced hepatic H\n            <jats:sub>2<\/jats:sub>\n            S fluctuations. Our findings provide the potential for advancing the feasibility of NIR-II activity-based sensing for in\u00a0vivo clinical diagnosis.\n          <\/jats:p>","DOI":"10.34133\/research.0286","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T10:23:39Z","timestamp":1700562219000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":18,"title":["A FRET-Based Ratiometric H\n            <sub>2<\/sub>\n            S Sensor for Sensitive Optical Molecular Imaging in Second Near-Infrared Window"],"prefix":"10.34133","volume":"6","author":[{"given":"Shan","family":"Lei","sequence":"first","affiliation":[{"name":"Marshall Laboratory of Biomedical Engineering, International Cancer Center, Shenzhen Key Laboratory of Tumor Visualization Molecular Medicine, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, \rShenzhen University Medical School, Shenzhen University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejia","family":"Jiang","sequence":"additional","affiliation":[{"name":"Marshall Laboratory of Biomedical Engineering, International Cancer Center, Shenzhen Key Laboratory of Tumor Visualization Molecular Medicine, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, \rShenzhen University Medical School, Shenzhen University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Marshall Laboratory of Biomedical Engineering, International Cancer Center, Shenzhen Key Laboratory of Tumor Visualization Molecular Medicine, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, \rShenzhen University Medical School, Shenzhen University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Marshall Laboratory of Biomedical Engineering, International Cancer Center, Shenzhen Key Laboratory of Tumor Visualization Molecular Medicine, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, \rShenzhen University Medical School, Shenzhen University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuantao","family":"Pan","sequence":"additional","affiliation":[{"name":"Marshall Laboratory of Biomedical Engineering, International Cancer Center, Shenzhen Key Laboratory of Tumor Visualization Molecular Medicine, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, \rShenzhen University Medical School, Shenzhen University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for AIE Research, College of Materials Science and Engineering, \rShenzhen University, Shenzhen 518060, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[{"name":"Marshall Laboratory of Biomedical Engineering, International Cancer Center, Shenzhen Key Laboratory of Tumor Visualization Molecular Medicine, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, \rShenzhen University Medical School, Shenzhen University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[{"name":"Marshall Laboratory of Biomedical Engineering, International Cancer Center, Shenzhen Key Laboratory of Tumor Visualization Molecular Medicine, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, \rShenzhen University Medical School, Shenzhen University, Shenzhen 518055, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"issue":"10","key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1021\/acs.accounts.9b00386","article-title":"Activity-based sensing methods for monitoring the reactive carbon species carbon monoxide and formaldehyde in living systems","volume":"52","author":"Ohata J","year":"2019","unstructured":"Ohata J, Bruemmer KJ, Chang CJ. 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