{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T14:03:50Z","timestamp":1789221830094,"version":"build-2803163510"},"reference-count":68,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"name":"National Key Research and Development Project","award":["2022YFA1104500"],"award-info":[{"award-number":["2022YFA1104500"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108002 and 82225005"],"award-info":[{"award-number":["82020108002 and 82225005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970335 and 82170285"],"award-info":[{"award-number":["81970335 and 82170285"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000253"],"award-info":[{"award-number":["82000253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grant from Science and Technology Commission of Shanghai Municipality","award":["23410750100, 20DZ2255400 and 21XD1421300"],"award-info":[{"award-number":["23410750100, 20DZ2255400 and 21XD1421300"]}]},{"name":"Grant from Science and Technology Commission of Shanghai Municipality","award":["23010500300 and 21SQBS00100"],"award-info":[{"award-number":["23010500300 and 21SQBS00100"]}]},{"name":"Grant from Science and Technology Commission of Shanghai Municipality","award":["23ZR1422900"],"award-info":[{"award-number":["23ZR1422900"]}]},{"name":"the \u201cDawn\u201d Program of Shanghai Education Commission","award":["19SG34"],"award-info":[{"award-number":["19SG34"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772444"],"award-info":[{"award-number":["81772444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Exercise can stimulate physiological cardiac growth and provide cardioprotection effect in ischemia\/reperfusion (I\/R) injury. MiR-210 is regulated in the adaptation process induced by exercise; however, its impact on exercise-induced physiological cardiac growth and its contribution to exercise-driven cardioprotection remain unclear. We investigated the role and mechanism of miR-210 in exercise-induced physiological cardiac growth and explored whether miR-210 contributes to exercise-induced protection in alleviating I\/R injury. Here, we first observed that regular swimming exercise can markedly increase miR-210 levels in the heart and blood samples of rats and mice. Circulating miR-210 levels were also elevated after a programmed cardiac rehabilitation in patients that were diagnosed of coronary heart diseases. In 8-week swimming model in wild-type (WT) and miR-210 knockout (KO) rats, we demonstrated that miR-210 was not integral for exercise-induced cardiac hypertrophy but it did influence cardiomyocyte proliferative activity. In neonatal rat cardiomyocytes, miR-210 promoted cell proliferation and suppressed apoptosis while not altering cell size. Additionally, miR-210 promoted cardiomyocyte proliferation and survival in human embryonic stem cell-derived cardiomyocytes (hESC-CMs) and AC16 cell line, indicating its functional roles in human cardiomyocytes. We further identified miR-210 target genes, cyclin-dependent kinase 10 (CDK10) and ephrin-A3 (EFNA3), that regulate cardiomyocyte proliferation and apoptosis. Finally, miR-210 KO and WT rats were subjected to swimming exercise followed by I\/R injury. We demonstrated that miR-210 crucially contributed to exercise-driven cardioprotection against I\/R injury. In summary, this study elucidates the role of miR-210, an exercise-responsive miRNA, in promoting the proliferative activity of cardiomyocytes during physiological cardiac growth. Furthermore, miR-210 plays an essential role in mediating the protective effects of exercise against cardiac I\/R injury. Our findings suggest exercise as a potent nonpharmaceutical intervention for inducing miR-210, which can alleviate I\/R injury and promote cardioprotection.<\/jats:p>","DOI":"10.34133\/research.0327","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T12:11:54Z","timestamp":1707739914000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":35,"title":["Exercise-Induced miR-210 Promotes Cardiomyocyte Proliferation and Survival and Mediates Exercise-Induced Cardiac Protection against Ischemia\/Reperfusion Injury"],"prefix":"10.34133","volume":"7","author":[{"given":"Yihua","family":"Bei","sequence":"first","affiliation":[{"name":"Institute of Geriatrics (\rShanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China."},{"name":"Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), \rShanghai University, Shanghai 200444, China."},{"name":"Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, \rShanghai University, Shanghai 200444, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (\rShanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China."},{"name":"Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), \rShanghai University, Shanghai 200444, China."},{"name":"Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, \rShanghai University, Shanghai 200444, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Tongji Hospital, \rTongji University School of Medicine, Shanghai 200065, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuhua","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (\rShanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China."},{"name":"Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), \rShanghai University, Shanghai 200444, China."},{"name":"Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, \rShanghai University, Shanghai 200444, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinpeng","family":"Li","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), \rShanghai University, Shanghai 200444, China."},{"name":"Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, \rShanghai University, Shanghai 200444, China."},{"name":"School of Environmental and Chemical Engineering, \rShanghai University, Shanghai 200444, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (\rShanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China."},{"name":"Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), \rShanghai University, Shanghai 200444, China."},{"name":"Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, \rShanghai University, Shanghai 200444, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (\rShanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China."},{"name":"Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), \rShanghai University, Shanghai 200444, China."},{"name":"Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Medicine, \rShanghai University, Shanghai 200444, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Yin","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (\rShanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China."},{"name":"Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), \rShanghai University, Shanghai 200444, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (\rShanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China."},{"name":"Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), \rShanghai University, Shanghai 200444, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (\rShanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China."},{"name":"Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), \rShanghai University, Shanghai 200444, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (\rShanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China."},{"name":"Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), \rShanghai University, Shanghai 200444, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmin","family":"Meng","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (\rShanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchun","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (\rShanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China."},{"name":"Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), \rShanghai University, Shanghai 200444, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (\rShanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong 226011, China."},{"name":"Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), \rShanghai University, Shanghai 200444, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Program, Shanghai Xuhui Central Hospital\/Zhongshan-Xuhui Hospital, \rFudan University\/Shanghai Clinical Research Center, Shanghai 200031, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, \rNanjing University of Chinese Medicine, Nanjing 210023, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragos","family":"Cretoiu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, \rCarol Davila University of Medicine and Pharmacy, Bucharest 020031, Romania."},{"name":"Materno-Fetal Assistance Excellence Unit, Alessandrescu-Rusescu National Institute for Mother and Child Health, Bucharest 011062, 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