{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:01:24Z","timestamp":1783548084809,"version":"3.55.0"},"reference-count":84,"publisher":"American Association for the Advancement of Science (AAAS)","content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Cuproptosis-based cancer nanomedicine has received widespread attention recently. However, cuproptosis nanomedicine against pancreatic ductal adenocarcinoma (PDAC) is severely limited by cancer stem cells (CSCs), which reside in the hypoxic stroma and adopt glycolysis metabolism accordingly to resist cuproptosis-induced mitochondria damage. Here, we leverage hyperbaric oxygen (HBO) to regulate CSC metabolism by overcoming tumor hypoxia and to augment CSC elimination efficacy of polydopamine and hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanoparticles (CuET@PH NPs). Mechanistically, while HBO and CuET@PH NPs inhibit glycolysis and oxidative phosphorylation, respectively, the combination of HBO and CuET@PH NPs potently suppresses energy metabolism of CSCs, thereby achieving robust tumor inhibition of PDAC and elongating mice survival importantly. This study reveals novel insights into the effects of cuproptosis nanomedicine on PDAC CSC metabolism and suggests that the combination of HBO with cuproptosis nanomedicine holds significant clinical translation potential for PDAC patients.<\/jats:p>","DOI":"10.34133\/research.0335","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T13:09:50Z","timestamp":1708520990000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":31,"title":["Hyperbaric Oxygen Boosts Antitumor Efficacy of Copper-Diethyldithiocarbamate Nanoparticles against Pancreatic Ductal Adenocarcinoma by Regulating Cancer Stem Cell Metabolism"],"prefix":"10.34133","volume":"7","author":[{"given":"Chen","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyou","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangliang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."},{"name":"National Engineering Research Center for Nanomedicine, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."},{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."},{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."},{"name":"Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-4854","authenticated-orcid":true,"given":"Zifu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."},{"name":"National Engineering Research Center for Nanomedicine, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."},{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."},{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."},{"name":"Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, \rHuazhong University of Science and Technology, Wuhan 430074, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"issue":"1","key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel RL","year":"2023","unstructured":"Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J. Clin. 2023;73(1):17\u201348.","journal-title":"CA Cancer J. Clin."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0901557"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1404198"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0281-6"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21626"},{"issue":"1","key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1200\/OP.22.00328","article-title":"Pancreatic adenocarcinoma management","volume":"19","author":"Jiang Y","year":"2023","unstructured":"Jiang Y, Sohal DPS. Pancreatic adenocarcinoma management. J. Oncol. Pract. 2023;19(1):19.","journal-title":"J. Oncol. Pract."},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0300-1"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-1334"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2019"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316451"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00048.2019"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00329-7"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0363-5"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3114"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.01.072"},{"issue":"17","key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1200\/JCO.2008.16.6702","article-title":"Pancreatic cancer stem cells","volume":"26","author":"Lee CJ","year":"2008","unstructured":"Lee CJ, Dosch J, Simeone DM. Pancreatic cancer stem cells. J. Clin. Oncol. 2008;26(17):2806\u20132812.","journal-title":"J. Clin. Oncol."},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.127"},{"issue":"7","key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.4161\/cc.19679","article-title":"Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness","volume":"11","author":"Lonardo E","year":"2012","unstructured":"Lonardo E, Frias-Aldeguer J, Hermann PC, Heeschen C. Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness. Cell Cycle. 2012;11(7):1282\u20131290.","journal-title":"Cell Cycle"},{"issue":"4","key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.cell.2018.01.009","article-title":"CD10+ GPR77+ cancer-associated fibroblasts promote cancer formation and chemoresistance by sustaining cancer stemness","volume":"172","author":"Su S","year":"2018","unstructured":"Su S, Chen J, Yao H, Liu J, Yu S, Lao L, Wang M, Luo M, Xing Y, Chen F, et al. CD10+ GPR77+ cancer-associated fibroblasts promote cancer formation and chemoresistance by sustaining cancer stemness. Cell. 2018;172(4):841\u2013856.","journal-title":"Cell"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2012.07.001"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.04.014"},{"issue":"1","key":"e_1_3_4_23_2","article-title":"Targeting cancer stem cell pathways for cancer therapy","volume":"5","author":"Yang L","year":"2020","unstructured":"Yang L, Shi P, Zhao G, Xu J, Peng W, Zhang J, Zhang G, Wang X, Dong Z, Chen F, et al. Targeting cancer stem cell pathways for cancer therapy. Signal Transduct. Target. Ther. 2020;5(1).","journal-title":"Signal Transduct. Target. Ther."},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0293-2"},{"issue":"1","key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13045-020-01030-w","article-title":"Targeting hypoxic tumor microenvironment in pancreatic cancer","volume":"14","author":"Tao J","year":"2021","unstructured":"Tao J, Yang G, Zhou W, Qiu J, Chen G, Luo W, Zhao F, You L, Zheng L, Zhang T, et al. Targeting hypoxic tumor microenvironment in pancreatic cancer. J. Hematol. Oncol. 2021;14(1):14.","journal-title":"J. Hematol. Oncol."},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1804280"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012615-044438"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4409"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.11.017"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103545"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.02.013"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.152"},{"issue":"7524","key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nature13611","article-title":"Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function","volume":"514","author":"Viale A","year":"2014","unstructured":"Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sanchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014;514(7524):628.","journal-title":"Nature"},{"issue":"4","key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.cmet.2015.08.015","article-title":"MYC\/PGC-1 alpha balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cells","volume":"22","author":"Sancho P","year":"2015","unstructured":"Sancho P, Burgos-Ramos E, Tavera A, Kheir TB, Jagust P, Schoenhals M, Barneda D, Sellers K, Campos-Olivas R, Grana O, et al. MYC\/PGC-1 alpha balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cells. Cell Metab. 2015;22(4):590\u2013605.","journal-title":"Cell Metab."},{"issue":"13","key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.18632\/oncotarget.2120","article-title":"Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine","volume":"5","author":"Isayev O","year":"2014","unstructured":"Isayev O, Rausch V, Bauer N, Liu L, Fan P, Zhang Y, Gladkich J, Nwaeburu CC, Mattern J, Mollenhauer M, et al. Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine. Oncotarget. 2014;5(13):5177\u20135189.","journal-title":"Oncotarget"},{"issue":"1","key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41388-020-01518-2","article-title":"Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma","volume":"40","author":"Nimmakayala RK","year":"2021","unstructured":"Nimmakayala RK, Leon F, Rachagani S, Rauth S, Nallasamy P, Marimuthu S, Shailendra GK, Chhonker YS, Chugh S, Chirravuri R, et al. Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma. Oncogene. 2021;40(1):215\u2013231.","journal-title":"Oncogene"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0529"},{"issue":"2","key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41568-021-00417-2","article-title":"Connecting copper and cancer: From transition metal signalling to metalloplasia","volume":"22","author":"Ge EJ","year":"2022","unstructured":"Ge EJ, Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou Q, Franz KJ, Gohil VM, Gupta S, et al. Connecting copper and cancer: From transition metal signalling to metalloplasia. Nat. Rev. Cancer. 2022;22(2):102\u2013113.","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen L","year":"2022","unstructured":"Chen L, Min J, Wang F. Copper homeostasis and cuproptosis in health and disease. Signal Transduct. Target. Ther. 2022;7(1):378.","journal-title":"Signal Transduct. Target. Ther."},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"741316","DOI":"10.3389\/fmolb.2021.741316","article-title":"Recent advances in repurposing disulfiram and disulfiram derivatives as copper-dependent anticancer agents","volume":"8","author":"Kannappan V","year":"2021","unstructured":"Kannappan V, Ali M, Small B, Rajendran G, Elzhenni S, Taj H, Wang W, Dou Q. Recent advances in repurposing disulfiram and disulfiram derivatives as copper-dependent anticancer agents. Front. Mol. Biosci. 2021;8:741316.","journal-title":"Front. Mol. Biosci."},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25016"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"121335","DOI":"10.1016\/j.biomaterials.2021.121335","article-title":"Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens","volume":"281","author":"Lu Y","year":"2022","unstructured":"Lu Y, Pan Q, Gao W, Pu Y, Luo K, He B, Gu Z. Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens. Biomaterials. 2022;281:121335.","journal-title":"Biomaterials"},{"issue":"44","key":"e_1_3_4_43_2","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201700403","article-title":"Dual-targeting to cancer cells and M2 macrophages via biomimetic delivery of mannosylated albumin nanoparticles for drug-resistant cancer therapy","volume":"27","author":"Zhao P","year":"2017","unstructured":"Zhao P, Yin W, Wu A, Tang Y, Wang J, Pan Z, Lin T, Zhang M, Chen B, Duan Y, et al. Dual-targeting to cancer cells and M2 macrophages via biomimetic delivery of mannosylated albumin nanoparticles for drug-resistant cancer therapy. Adv. Funct. Mater. 2017;27(44): 1700403.","journal-title":"Adv. Funct. Mater."},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jconrel.2020.10.052","article-title":"Biomimetic codelivery overcomes osimertinib-resistant NSCLC and brain metastasis via macrophage-mediated innate immunity","volume":"329","author":"Zhao P","year":"2021","unstructured":"Zhao P, Zhang J, Wu A, Zhang M, Zhao Y, Tang Y, Wang B, Chen T, Li F, Zhao Q, et al. Biomimetic codelivery overcomes osimertinib-resistant NSCLC and brain metastasis via macrophage-mediated innate immunity. J. Control. Release. 2021;329:1249\u20131261.","journal-title":"J. Control. Release"},{"issue":"10","key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1039\/C7SC04853J","article-title":"Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophagemediated immunotherapy","volume":"9","author":"Zhao P","year":"2018","unstructured":"Zhao P, Wang Y, Kang X, Wu A, Yin W, Tang Y, Wang J, Zhang M, Duan Y, Huang Y. Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophagemediated immunotherapy. Chem. Sci. 2018;9(10):2674\u20132689.","journal-title":"Chem. Sci."},{"issue":"2","key":"e_1_3_4_46_2","doi-asserted-by":"crossref","first-page":"e000207","DOI":"10.1136\/jitc-2019-000207","article-title":"Remodeling tumor immune microenvironment (TIME) for glioma therapy using multi-targeting liposomal codelivery","volume":"8","author":"Zheng Z","year":"2020","unstructured":"Zheng Z, Zhang J, Jiang J, He Y, Zhang W, Mo X, Kang X, Xu Q, Wang B, Huang Y. Remodeling tumor immune microenvironment (TIME) for glioma therapy using multi-targeting liposomal codelivery. J. Immunother. Cancer. 2020;8(2):e000207.","journal-title":"J. Immunother. Cancer"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.02.043"},{"issue":"10","key":"e_1_3_4_48_2","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/bjc.2011.126","article-title":"Disulfiram modulated ROS-MAPK and NF\u03baB pathways and targeted breast cancer cells with cancer stem cell-like properties","volume":"104","author":"Yip NC","year":"2011","unstructured":"Yip NC, Fombon IS, Liu P, Brown S, Kannappan V, Armesilla AL, Xu B, Cassidy J, Darling JL, Wang W. Disulfiram modulated ROS-MAPK and NF\u03baB pathways and targeted breast cancer cells with cancer stem cell-like properties. Br. J. Cancer. 2011;104(10):1564\u20131574.","journal-title":"Br. J. Cancer"},{"issue":"9","key":"e_1_3_4_49_2","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/bjc.2012.442","article-title":"Cytotoxic effect of disulfiram\/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells","volume":"107","author":"Liu P","year":"2012","unstructured":"Liu P, Brown S, Goktug T, Channathodiyil P, Kannappan V, Hugnot JP, Guichet PO, Bian X, Armesilla AL, Darling JL, et al. Cytotoxic effect of disulfiram\/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells. Br. J. Cancer. 2012;107(9):1488\u20131497.","journal-title":"Br. J. Cancer"},{"issue":"7","key":"e_1_3_4_50_2","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1038\/bjc.2013.534","article-title":"Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells","volume":"109","author":"Liu P","year":"2013","unstructured":"Liu P, Kumar IS, Brown S, Kannappan V, Tawari PE, Tang JZ, Jiang W, Armesilla AL, Darling JL, Wang W. Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells. Br. J. Cancer. 2013;109(7):1876\u20131885.","journal-title":"Br. J. Cancer"},{"issue":"17","key":"e_1_3_4_51_2","doi-asserted-by":"crossref","first-page":"7471","DOI":"10.18632\/oncotarget.2166","article-title":"Liposome encapsulated disulfiram inhibits NF\u03baB pathway and targets breast cancer stem cells in\u00a0vitro and in\u00a0vivo","volume":"5","author":"Liu P","year":"2014","unstructured":"Liu P, Wang Z, Brown S, Kannappan V, Tawari PE, Jiang W, Irache JM, Tang JZ, Armesilla AL, Darling JL, et al. Liposome encapsulated disulfiram inhibits NF\u03baB pathway and targets breast cancer stem cells in\u00a0vitro and in\u00a0vivo. Oncotarget. 2014;5(17):7471\u20137485.","journal-title":"Oncotarget"},{"issue":"2","key":"e_1_3_4_52_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.nano.2016.08.001","article-title":"Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells","volume":"13","author":"Wang Z","year":"2017","unstructured":"Wang Z, Tan J, McConville C, Kannappan V, Tawari PE, Brown J, Ding J, Armesilla AL, Irache JM, Mei QB, et al. Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells. Nanomedicine. 2017;13(2):641\u2013657.","journal-title":"Nanomedicine"},{"issue":"4","key":"e_1_3_4_53_2","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.bbrc.2017.03.164","article-title":"Disulfiram suppresses cancer stem-like properties and STAT3 signaling in triple-negative breast cancer cells","volume":"486","author":"Kim YJ","year":"2017","unstructured":"Kim YJ, Kim JY, Lee N, Oh E, Sung D, Cho TM, Seo JH. Disulfiram suppresses cancer stem-like properties and STAT3 signaling in triple-negative breast cancer cells. Biochem. Biophys. Res. Commun. 2017;486(4):1069\u20131076.","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"16","key":"e_1_3_4_54_2","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.7150\/jca.57752","article-title":"miR-30a\/SOX4 double negative feedback loop is modulated by disulfiram and regulates EMT and stem cell-like properties in breast cancer","volume":"12","author":"Liu Z","year":"2021","unstructured":"Liu Z, Mi M, Zheng X, Zhang C, Zhu F, Liu T, Wu G, Zhang L. miR-30a\/SOX4 double negative feedback loop is modulated by disulfiram and regulates EMT and stem cell-like properties in breast cancer. J. Cancer. 2021;12(16):5053\u20135065.","journal-title":"J. Cancer"},{"issue":"36","key":"e_1_3_4_55_2","doi-asserted-by":"crossref","first-page":"58516","DOI":"10.18632\/oncotarget.11305","article-title":"Targeting ALDH1A1 by disulfiram\/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells","volume":"7","author":"Liu X","year":"2016","unstructured":"Liu X, Wang L, Cui W, Yuan X, Lin L, Cao Q, Wang N, Li Y, Guo W, Zhang X, et al. Targeting ALDH1A1 by disulfiram\/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells. Oncotarget. 2016;7(36):58516\u201358530.","journal-title":"Oncotarget"},{"issue":"5","key":"e_1_3_4_56_2","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.176","article-title":"Disulfiram\/copper selectively eradicates AML leukemia stem cells in\u00a0vitro and in\u00a0vivo by simultaneous induction of ROS-JNK and inhibition of NF-\u03baB and Nrf2","volume":"8","author":"Xu B","year":"2017","unstructured":"Xu B, Wang S, Li R, Chen K, He L, Deng M, Kannappan V, Zha J, Dong H, Wang W. Disulfiram\/copper selectively eradicates AML leukemia stem cells in\u00a0vitro and in\u00a0vivo by simultaneous induction of ROS-JNK and inhibition of NF-\u03baB and Nrf2. Cell Death Dis. 2017;8(5): e2797.","journal-title":"Cell Death Dis."},{"key":"e_1_3_4_57_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.canlet.2021.02.002","article-title":"Targeting cancer stem cells by disulfiram and copper sensitizes radioresistant chondrosarcoma to radiation","volume":"505","author":"Wang K","year":"2021","unstructured":"Wang K, Michelakos T, Wang B, Shang Z, DeLeo AB, Duan Z, Hornicek FJ, Schwab JH, Wang X. Targeting cancer stem cells by disulfiram and copper sensitizes radioresistant chondrosarcoma to radiation. Cancer Lett. 2021;505:37\u201348.","journal-title":"Cancer Lett."},{"key":"e_1_3_4_58_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.canlet.2017.08.028","article-title":"A novel chemoradiation targeting stem and nonstem pancreatic cancer cells by repurposing disulfiram","volume":"409","author":"Cong J","year":"2017","unstructured":"Cong J, Wang Y, Zhang X, Zhang N, Liu L, Soukup K, Michelakos T, Hong T, DeLeo A, Cai L, et al. A novel chemoradiation targeting stem and nonstem pancreatic cancer cells by repurposing disulfiram. Cancer Lett. 2017;409:9\u201319.","journal-title":"Cancer Lett."},{"issue":"1","key":"e_1_3_4_59_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbagen.2018.09.018","article-title":"Pancreatic cancer stem cell proliferation is strongly inhibited by diethyldithiocarbamate-copper complex loaded into hyaluronic acid decorated liposomes","volume":"1863","author":"Marengo A","year":"2019","unstructured":"Marengo A, Forciniti S, Dando I, Dalla Pozza E, Stella B, Tsapis N, Yagoubi N, Fanelli G, Fattal E, Heeschen C, et al. Pancreatic cancer stem cell proliferation is strongly inhibited by diethyldithiocarbamate-copper complex loaded into hyaluronic acid decorated liposomes. Biochim Biophys Acta Gen Subj. 2019;1863(1):61\u201372.","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00635"},{"key":"e_1_3_4_61_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101767","article-title":"Mild photothermal therapy boosts nanomedicine antitumor efficacy by disrupting DNA damage repair pathways and modulating tumor mechanics","volume":"49","author":"Xiong Y","year":"2023","unstructured":"Xiong Y, Wang W, Deng Q, Zhang Z, Wang Q, Yong Z, Sun C, Yang X, Li Z. Mild photothermal therapy boosts nanomedicine antitumor efficacy by disrupting DNA damage repair pathways and modulating tumor mechanics. Nano Today. 2023;49: 101767.","journal-title":"Nano Today"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.11.059"},{"issue":"5","key":"e_1_3_4_63_2","doi-asserted-by":"crossref","first-page":"7323","DOI":"10.1007\/s12274-023-5394-7","article-title":"Targeting cancer-associated fibroblasts with hydroxyethyl starch nanomedicine boosts cancer therapy","volume":"16","author":"Wang C","year":"2023","unstructured":"Wang C, Wang H, Yang H, Xu C, Wang Q, Li Z, Zhang Z, Guan J, Yu X, Yang X, et al. Targeting cancer-associated fibroblasts with hydroxyethyl starch nanomedicine boosts cancer therapy. Nano Res. 2023;16(5):7323\u20137336.","journal-title":"Nano Res"},{"issue":"21","key":"e_1_3_4_64_2","doi-asserted-by":"crossref","first-page":"2301278","DOI":"10.1002\/advs.202301278","article-title":"Hyperbaric oxygen activates enzyme-driven cascade reactions for cooperative cancer therapy and cancer stem cells elimination","volume":"10","author":"Xiong Y","year":"2023","unstructured":"Xiong Y, Yong Z, Xu C, Deng Q, Wang Q, Li S, Wang C, Zhang Z, Yang X, Li Z. Hyperbaric oxygen activates enzyme-driven cascade reactions for cooperative cancer therapy and cancer stem cells elimination. Adv. Sci. 2023;10(21):2301278.","journal-title":"Adv. Sci."},{"key":"e_1_3_4_65_2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jconrel.2023.03.001","article-title":"Doxorubicin and erastin co-loaded hydroxyethyl starch-polycaprolactone nanoparticles for synergistic cancer therapy","volume":"356","author":"Xu C","year":"2023","unstructured":"Xu C, Li S, Chen J, Wang H, Li Z, Deng Q, Li J, Wang X, Xiong Y, Zhang Z, et al. Doxorubicin and erastin co-loaded hydroxyethyl starch-polycaprolactone nanoparticles for synergistic cancer therapy. J. Control. Release. 2023;356:256\u2013271.","journal-title":"J. Control. Release"},{"issue":"2","key":"e_1_3_4_66_2","doi-asserted-by":"crossref","first-page":"944","DOI":"10.7150\/thno.67572","article-title":"Tumor-specific activatable biopolymer nanoparticles stabilized by hydroxyethyl starch prodrug for self-amplified cooperative cancer therapy","volume":"12","author":"Xiong Y","year":"2022","unstructured":"Xiong Y, Wang Z, Wang Q, Deng Q, Chen J, Wei J, Yang X, Yang X, Li Z. Tumor-specific activatable biopolymer nanoparticles stabilized by hydroxyethyl starch prodrug for self-amplified cooperative cancer therapy. Theranostics. 2022;12(2):944\u2013962.","journal-title":"Theranostics"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00718H"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101458"},{"key":"e_1_3_4_69_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101248","article-title":"Hyperbaric oxygen regulates tumor microenvironment and boosts commercialized nanomedicine delivery for potent eradication of cancer stem-like cells","volume":"40","author":"Liu X","year":"2021","unstructured":"Liu X, Ye N, Xiao C, Wang X, Li S, Deng Y, Yang X, Li Z, Yang X. Hyperbaric oxygen regulates tumor microenvironment and boosts commercialized nanomedicine delivery for potent eradication of cancer stem-like cells. Nano Today. 2021;40: 101248.","journal-title":"Nano Today"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.34133\/research.0223"},{"key":"e_1_3_4_71_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106740","article-title":"A novel lonidamine derivative targeting mitochondria to eliminate cancer stem cells by blocking glutamine metabolism","volume":"190","author":"Wang Q","year":"2023","unstructured":"Wang Q, Li S, Xu C, Hua A, Wang C, Xiong Y, Deng Q, Chen X, Yang T, Wan J, et al. A novel lonidamine derivative targeting mitochondria to eliminate cancer stem cells by blocking glutamine metabolism. Pharmacol. Res. 2023;190: 106740.","journal-title":"Pharmacol. Res."},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121180"},{"key":"e_1_3_4_73_2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cej.2018.05.082","article-title":"Hydroxyethyl starch stabilized polydopamine nanoparticles for cancer chemotherapy","volume":"349","author":"Wu H","year":"2018","unstructured":"Wu H, Hu H, Wan J, Li Y, Wu Y, Tang Y, Xiao C, Xu H, Yang X, Li Z. Hydroxyethyl starch stabilized polydopamine nanoparticles for cancer chemotherapy. Chem. Eng. J. 2018;349:129\u2013145.","journal-title":"Chem. Eng. J."},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA09663F"},{"issue":"22","key":"e_1_3_4_75_2","doi-asserted-by":"crossref","first-page":"19215","DOI":"10.1021\/acsami.7b04066","article-title":"\u03b1-Amylase- and redox-responsive nanoparticles for tumor-targeted drug delivery","volume":"9","author":"Li Y","year":"2017","unstructured":"Li Y, Hu H, Zhou Q, Ao Y, Xiao C, Wan J, Wan Y, Xu H, Li Z, Yang X. \u03b1-Amylase- and redox-responsive nanoparticles for tumor-targeted drug delivery. ACS Appl Mater. 2017;9(22):19215\u201319230.","journal-title":"ACS Appl Mater"},{"issue":"48","key":"e_1_3_4_76_2","doi-asserted-by":"crossref","first-page":"42225","DOI":"10.1021\/acsami.7b14796","article-title":"Nanocolloidosomes with selective drug release for active tumor-targeted imaging-guided photothermal\/chemo combination therapy","volume":"9","author":"Hu H","year":"2017","unstructured":"Hu H, Xiao C, Wu H, Li Y, Zhou Q, Tang Y, Yu C, Yang X, Li Z. Nanocolloidosomes with selective drug release for active tumor-targeted imaging-guided photothermal\/chemo combination therapy. ACS Appl Mater. 2017;9(48):42225\u201342238.","journal-title":"ACS Appl Mater"},{"issue":"8","key":"e_1_3_4_77_2","doi-asserted-by":"crossref","first-page":"1700859","DOI":"10.1002\/advs.201700859","article-title":"Hyperbaric oxygen potentiates doxil antitumor efficacy by promoting tumor penetration and sensitizing cancer cells","volume":"5","author":"Wu X","year":"2018","unstructured":"Wu X, Zhu Y, Huang W, Li J, Zhang B, Li Z, Yang X. Hyperbaric oxygen potentiates doxil antitumor efficacy by promoting tumor penetration and sensitizing cancer cells. Adv. Sci. 2018;5(8):1700859.","journal-title":"Adv. Sci."},{"key":"e_1_3_4_78_2","doi-asserted-by":"crossref","first-page":"9854904","DOI":"10.34133\/2022\/9854904","article-title":"lncRNA HITT inhibits lactate production by repressing PKM2 oligomerization to reduce tumor growth and macrophage polarization","volume":"2022","author":"Zhao K","year":"2022","unstructured":"Zhao K, Wang X, Zhao D, Lin Q, Zhang Y, Hu Y. lncRNA HITT inhibits lactate production by repressing PKM2 oligomerization to reduce tumor growth and macrophage polarization. Research. 2022;2022:9854904.","journal-title":"Research"},{"key":"e_1_3_4_79_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-3-030-58174-9_4","article-title":"Boosting nanomedicine efficacy with hyperbaric oxygen therapy","volume":"1295","author":"Wang X","year":"2021","unstructured":"Wang X, Li S, Liu X, Wu X, Ye N, Yang X, Li Z. Boosting nanomedicine efficacy with hyperbaric oxygen therapy. Adv. Exp. Med. Biol. 2021;1295:77\u201395.","journal-title":"Adv. Exp. Med. Biol."},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.34133\/research.0184"},{"issue":"22","key":"e_1_3_4_81_2","doi-asserted-by":"crossref","first-page":"2212267","DOI":"10.1002\/adma.202212267","article-title":"Cuproptosis induced by ROS responsive nanoparticles with elesclomol and copper combined with \u03b1PD-L1 for enhanced cancer immunotherapy","volume":"35","author":"Guo B","year":"2023","unstructured":"Guo B, Yang F, Zhang L, Zhao Q, Wang W, Yin L, Chen D, Wang M, Han S, Xiao H, et al. Cuproptosis induced by ROS responsive nanoparticles with elesclomol and copper combined with \u03b1PD-L1 for enhanced cancer immunotherapy. Adv. Mater. 2023;35(22):2212267.","journal-title":"Adv. Mater."},{"issue":"13","key":"e_1_3_4_82_2","doi-asserted-by":"crossref","first-page":"2202949","DOI":"10.1002\/adhm.202202949","article-title":"Tumor microenvironment responsive hollow nanoplatform for triple amplification of oxidative stress to enhance cuproptosis-based synergistic cancer therapy","volume":"12","author":"Xu W","year":"2023","unstructured":"Xu W, Wang Y, Hou G, Wang J, Wang T, Qian J, Suo A. Tumor microenvironment responsive hollow nanoplatform for triple amplification of oxidative stress to enhance cuproptosis-based synergistic cancer therapy. Adv. Healthc. Mater. 2023;12(13):2202949.","journal-title":"Adv. Healthc. Mater."},{"issue":"7239","key":"e_1_3_4_83_2","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature07733","article-title":"Association of reactive oxygen species levels and radioresistance in cancer stem cells","volume":"458","author":"Diehn M","year":"2009","unstructured":"Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 2009;458(7239):780\u2013783.","journal-title":"Nature"},{"issue":"1","key":"e_1_3_4_84_2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13046-023-02720-2","article-title":"Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer","volume":"42","author":"Wang W","year":"2023","unstructured":"Wang W, Lu K, Jiang X, Wei Q, Zhu L, Wang X, Jin H, Feng L. Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer. J. Exp. Clin. Cancer Res. 2023;42(1):142.","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.08.005"}],"container-title":["Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.34133\/research.0335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T02:46:58Z","timestamp":1710211618000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.34133\/research.0335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":84,"alternative-id":["10.34133\/research.0335"],"URL":"https:\/\/doi.org\/10.34133\/research.0335","relation":{},"ISSN":["2639-5274"],"issn-type":[{"value":"2639-5274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"0335"}}