{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:46:04Z","timestamp":1781570764418,"version":"3.54.5"},"reference-count":17,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council of Singapore","doi-asserted-by":"crossref","award":["OFIRG21jun-0058"],"award-info":[{"award-number":["OFIRG21jun-0058"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n            <jats:italic>Candida albicans<\/jats:italic>\n            is an opportunistic fungal pathogen of humans. It causes a variety of infections ranging from superficial mucocutaneous conditions to severe systemic diseases that result in substantial morbidity and mortality. This pathogen frequently forms biofilms resistant to antifungal drugs and the host immune system, leading to treatment failures. Recent research has demonstrated the potential of nanorobots to penetrate biological barriers and disrupt fungal biofilms. In this perspective paper, we provide a brief overview of recent breakthroughs in nanorobots for candidiasis treatment and discuss current challenges and prospects.\n          <\/jats:p>","DOI":"10.34133\/research.0455","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T10:17:41Z","timestamp":1722421061000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":13,"title":["Nanorobots to Treat\n            <i>Candida albicans<\/i>\n            Infection"],"prefix":"10.34133","volume":"7","author":[{"given":"Yanling","family":"Hu","sequence":"first","affiliation":[{"name":"College of Life and Health, \rNanjing Polytechnic Institute, Nanjing 210048, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guisheng","family":"Zeng","sequence":"additional","affiliation":[{"name":"A*STAR Infectious Diseases Labs (A*STAR ID Labs), \rAgency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #05-13 Immunos, Singapore 138648, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"A*STAR Infectious Diseases Labs (A*STAR ID Labs), \rAgency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #05-13 Immunos, Singapore 138648, Singapore."},{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine, \rNational University of Singapore, Singapore 117597."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8605-6720","authenticated-orcid":true,"given":"Dongliang","family":"Yang","sequence":"additional","affiliation":[{"name":"A*STAR Infectious Diseases Labs (A*STAR ID Labs), \rAgency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, #05-13 Immunos, Singapore 138648, Singapore."},{"name":"Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, \rNanjing Tech University (NanjingTech), Nanjing 211816, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116243","article-title":"Recent advances towards point-of-care devices for fungal detection: Emphasizing the role of plasmonic nanomaterials in current and future technologies","volume":"255","author":"Stoia D","year":"2024","unstructured":"Stoia D, de Sio L, Petronella F, Focsan M. Recent advances towards point-of-care devices for fungal detection: Emphasizing the role of plasmonic nanomaterials in current and future technologies. Biosens Bioelectron. 2024;255: Article 116243.","journal-title":"Biosens Bioelectron"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114960","article-title":"Candidiasis: From cutaneous to systemic, new perspectives of potential targets and therapeutic strategies","volume":"199","author":"Lu H","year":"2023","unstructured":"Lu H, Hong T, Jiang Y, Whiteway M, Zhang S. Candidiasis: From cutaneous to systemic, new perspectives of potential targets and therapeutic strategies. Adv Drug Deliv Rev. 2023;199: Article 114960.","journal-title":"Adv Drug Deliv Rev"},{"issue":"5","key":"e_1_3_2_4_2","doi-asserted-by":"crossref","DOI":"10.1016\/S1473-3099(24)00103-8","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"Denning DW","year":"2024","unstructured":"Denning DW. Global incidence and mortality of severe fungal disease. Lancet Infect Dis. 2024;24(5): Article e268.","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1038\/s41467-021-22845-2","article-title":"A peptidoglycan storm caused by \u03b2-lactam antibiotic\u2019s action on host microbiota drives Candida albicans infection","volume":"12","author":"Tan CT","year":"2021","unstructured":"Tan CT, Xu X, Qiao Y, Wang Y. A peptidoglycan storm caused by \u03b2-lactam antibiotic\u2019s action on host microbiota drives Candida albicans infection. Nat Commun. 2021;12(1):2560.","journal-title":"Nat Commun"},{"issue":"9","key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"14218","DOI":"10.1021\/acsnano.1c01379","article-title":"Multifunctional parachute-like nanomotors for enhanced skin penetration and synergistic antifungal therapy","volume":"15","author":"Ji X","year":"2021","unstructured":"Ji X, Yang H, Liu W, Ma Y, Wu J, Zong X, Yuan P, Chen X, Yang C, Li X, et al. Multifunctional parachute-like nanomotors for enhanced skin penetration and synergistic antifungal therapy. ACS Nano. 2021;15(9):14218\u201314228.","journal-title":"ACS Nano"},{"issue":"3","key":"e_1_3_2_7_2","first-page":"199","article-title":"Cis-2-dodecenoic acid mediates its synergistic effect with triazoles by interfering with efflux pumps in fluconazole-resistant Candida albicans","volume":"32","author":"Yang DL","year":"2019","unstructured":"Yang DL, Hu YL, Yin ZX, Zeng GS, Li D, Zhang YQ, Xu ZH, Guan XM, Weng LX, Wang LH. Cis-2-dodecenoic acid mediates its synergistic effect with triazoles by interfering with efflux pumps in fluconazole-resistant Candida albicans. Biomed Environ Sci. 2019;32(3):199\u2013209.","journal-title":"Biomed Environ Sci"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00905-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00564J"},{"issue":"7655","key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/545406a","article-title":"Medical microbots need better imaging and control","volume":"545","author":"Medina-S\u00e1nchez M","year":"2017","unstructured":"Medina-S\u00e1nchez M, Schmidt OG. Medical microbots need better imaging and control. Nature. 2017;545(7655):406\u2013408.","journal-title":"Nature"},{"issue":"6","key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"e2101991","DOI":"10.1002\/adhm.202101991","article-title":"Micro-\/nanorobots in antimicrobial applications: Recent progress, challenges, and opportunities","volume":"11","author":"Zhang Z","year":"2022","unstructured":"Zhang Z, Wang L, Chan TKF, Chen Z, Ip M, Chan PKS, Sung JJY, Zhang L. Micro-\/nanorobots in antimicrobial applications: Recent progress, challenges, and opportunities. Adv Healthc Mater. 2022;11(6):e2101991.","journal-title":"Adv Healthc Mater"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"7962024","DOI":"10.34133\/2020\/7962024","article-title":"Magnetic nanomotor-based maneuverable SERS probe","volume":"2020","author":"Wang Y","year":"2020","unstructured":"Wang Y, Liu Y, Li Y, Xu D, Pan X, Chen Y, Zhou D, Wang B, Feng H, Ma X. Magnetic nanomotor-based maneuverable SERS probe. 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Stimuli-actuated turn-on theranostic nanoplatforms for imaging-guided antibacterial treatment. Small. 2023;19(52):e2304127.","journal-title":"Small"}],"container-title":["Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.34133\/research.0455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T07:45:07Z","timestamp":1723707907000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.34133\/research.0455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":17,"alternative-id":["10.34133\/research.0455"],"URL":"https:\/\/doi.org\/10.34133\/research.0455","relation":{},"ISSN":["2639-5274"],"issn-type":[{"value":"2639-5274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"0455"}}