{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:03:29Z","timestamp":1783645409246,"version":"3.55.0"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030060"],"award-info":[{"award-number":["82030060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["spj.science.org"],"crossmark-restriction":true},"short-container-title":["Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n            Neutrophils are essential in combating invading pathogens such as\n            <jats:italic>Plasmodium<\/jats:italic>\n            parasites, but the participation of their subpopulations and mechanisms in resistance to parasite infection are not fully understood. Our study identified a marked increase in Ly6G\n            <jats:sup>+<\/jats:sup>\n            neutrophils in response to\n            <jats:italic>P. berghei<\/jats:italic>\n            ANKA infection. Depletion of these cells rendered mice more susceptible to infection. Elevated interleukin-17 (IL-17) levels, which increased the Ly6G\n            <jats:sup>+<\/jats:sup>\n            neutrophil population, were also found to contribute to this protective effect. IL-17 depletion led to reduced neutrophil numbers and increased susceptibility. Furthermore, dihydroartemisinin (DHA) treatment enhanced neutrophil-mediated immune responses through up-regulation of CD18 and CXCR4 factors. These findings revealed key mechanisms of neutrophil and IL-17 interactions in malaria protection and highlighted DHA\u2019s potential to promote neutrophil function in combating malaria.\n          <\/jats:p>","DOI":"10.34133\/research.0559","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T20:45:41Z","timestamp":1733863541000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["Ly6G\n            <sup>+<\/sup>\n            Neutrophils and Interleukin-17 Are Essential in Protection against Rodent Malaria Caused by\n            <i>Plasmodium berghei<\/i>\n            ANKA"],"prefix":"10.34133","volume":"7","author":[{"given":"Ziwei","family":"Su","sequence":"first","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunying","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anni","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Sang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0356-7435","authenticated-orcid":true,"given":"Qijun","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, \rCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China."},{"name":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang 110866, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3RI1018-400R"},{"issue":"1","key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1038\/s41467-024-49348-0","article-title":"SOD3 suppresses early cellular immune responses to parasite infection","volume":"15","author":"Li Q","year":"2024","unstructured":"Li Q, Lv K, Jiang N, Liu T, Hou N, Yu L, Yang Y, Feng A, Zhang Y, Su Z, et al. SOD3 suppresses early cellular immune responses to parasite infection. Nat Commun. 2024;15(1):4913.","journal-title":"Nat Commun"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112843","article-title":"Plasmodium berghei TatD-like DNase hijacks host innate immunity by inhibiting the TLR9-NF-\u03baB pathway","volume":"140","author":"Fan R","year":"2024","unstructured":"Fan R, Li Q, Jiang N, Zhang Y, Yu L, Zheng Y, Su Z, Zhang N, Chen R, Feng Y, et al. Plasmodium berghei TatD-like DNase hijacks host innate immunity by inhibiting the TLR9-NF-\u03baB pathway. Int Immunopharmacol. 2024;140:Article 112843.","journal-title":"Int Immunopharmacol"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"11537","DOI":"10.1038\/ncomms11537","article-title":"The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate","volume":"7","author":"Chang Z","year":"2016","unstructured":"Chang Z, Jiang N, Zhang Y, Lu H, Yin J, Wahlgren M, Cheng X, Cao Y, Chen Q. The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate. Nat Commun. 2016;7:11537.","journal-title":"Nat Commun"},{"issue":"1","key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/cei.13254","article-title":"Analysis of antibody responses to selected Plasmodium falciparum merozoite surface antigens in mild and cerebral malaria and associations with clinical outcomes","volume":"196","author":"Mbengue B","year":"2019","unstructured":"Mbengue B, Fall MM, Varela ML, Loucoubar C, Joos C, Fall B, Niang MS, Niang B, Mbow M, Dieye A, et al. Analysis of antibody responses to selected Plasmodium falciparum merozoite surface antigens in mild and cerebral malaria and associations with clinical outcomes. Clin Exp Immunol. 2019;196(1):86\u201396.","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"e_1_3_3_7_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009871","article-title":"Clinical protection from falciparum malaria correlates with neutrophil respiratory bursts induced by merozoites opsonized with human serum antibodies","volume":"5","author":"Joos C","year":"2010","unstructured":"Joos C, Marrama L, Polson HE, Corre S, Diatta AM, Diouf B, Trape JF, Tall A, Longacre S, Perraut R. Clinical protection from falciparum malaria correlates with neutrophil respiratory bursts induced by merozoites opsonized with human serum antibodies. PLOS ONE. 2010;5(3):Article e9871.","journal-title":"PLOS ONE"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-139634"},{"issue":"6","key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2011.08.024","article-title":"Artemisinin: Discovery from the Chinese herbal garden","volume":"146","author":"Miller LH","year":"2011","unstructured":"Miller LH, Su X. Artemisinin: Discovery from the Chinese herbal garden. Cell. 2011;146(6):855\u2013858.","journal-title":"Cell"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2471"},{"issue":"1","key":"e_1_3_3_11_2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s41467-019-08297-9","article-title":"Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children","volume":"10","author":"Chotsiri P","year":"2019","unstructured":"Chotsiri P, Zongo I, Milligan P, Compaore YD, Som\u00e9 AF, Chandramohan D, Hanpithakpong W, Nosten F, Greenwood B, Rosenthal PJ, et al. Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children. Nat Commun. 2019;10(1):480.","journal-title":"Nat Commun"},{"issue":"6","key":"e_1_3_3_12_2","first-page":"2213","article-title":"Dihydroartemisinin attenuates lipopolysaccharide-induced acute lung injury in mice by suppressing NF-\u03baB signaling in an Nrf2-dependent manner","volume":"44","author":"Huang XT","year":"2019","unstructured":"Huang XT, Liu W, Zhou Y, Hao CX, Zhou Y, Zhang CY, Sun CC, Luo ZQ, Tang SY. Dihydroartemisinin attenuates lipopolysaccharide-induced acute lung injury in mice by suppressing NF-\u03baB signaling in an Nrf2-dependent manner. Int J Mol Med. 2019;44(6):2213\u20132222.","journal-title":"Int J Mol Med"},{"issue":"1","key":"e_1_3_3_13_2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41392-022-01028-5","article-title":"Dihydroartemisinin regulates immune cell heterogeneity by triggering a cascade reaction of CDK and MAPK phosphorylation","volume":"7","author":"Li Q","year":"2022","unstructured":"Li Q, Yuan Q, Jiang N, Zhang Y, Su Z, Lv L, Sang X, Chen R, Feng Y, Chen Q. Dihydroartemisinin regulates immune cell heterogeneity by triggering a cascade reaction of CDK and MAPK phosphorylation. Signal Transduct Target Ther. 2022;7(1):222.","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0008-6363(96)00052-1","article-title":"Carbohydrate- and CD18-dependent neutrophil adhesion to cardiac myocytes: Effects of adenosine","volume":"32","author":"Bullough DA","year":"1996","unstructured":"Bullough DA, Magill MJ, Mullane KM, Firestein GS. Carbohydrate- and CD18-dependent neutrophil adhesion to cardiac myocytes: Effects of adenosine. Cardiovasc Res. 1996;32(2):328\u2013334.","journal-title":"Cardiovasc Res"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0227-1"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001638"},{"issue":"11","key":"e_1_3_3_17_2","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1167\/iovs.07-0562","article-title":"Neutrophil interactions with keratocytes during corneal epithelial wound healing: A role for CD18 integrins","volume":"48","author":"Petrescu MS","year":"2007","unstructured":"Petrescu MS, Larry CL, Bowden RA, Williams GW, Gagen D, Li Z, Smith CW, Burns AR. Neutrophil interactions with keratocytes during corneal epithelial wound healing: A role for CD18 integrins. Invest Ophthalmol Vis Sci. 2007;48(11):5023\u20135029.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-021-2061-7"},{"issue":"8","key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1084\/jem.20182227","article-title":"CXCR4 regulates Plasmodium development in mouse and human hepatocytes","volume":"216","author":"Bando H","year":"2019","unstructured":"Bando H, Pradipta A, Iwanaga S, Okamoto T, Okuzaki D, Tanaka S, Vega-Rodr\u00edguez J, Lee Y, Ma JS, Sakaguchi N, et al. CXCR4 regulates Plasmodium development in mouse and human hepatocytes. J Exp Med. 2019;216(8):1733\u20131748.","journal-title":"J Exp Med"},{"issue":"1","key":"e_1_3_3_20_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0165-2478(02)00067-6","article-title":"Stromal cell derived factor 1 synthesis by spleen cells in rodent malaria, and the effects of in\u00a0vivo supplementation of SDF-1\u03b1 and CXCR4 receptor blocker","volume":"83","author":"Garnica MR","year":"2002","unstructured":"Garnica MR, Souto JT, Silva JS, De Andrade HF, Jr. Stromal cell derived factor 1 synthesis by spleen cells in rodent malaria, and the effects of in\u00a0vivo supplementation of SDF-1\u03b1 and CXCR4 receptor blocker. Immunol Lett. 2002;83(1):47\u201353.","journal-title":"Immunol Lett"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.04.011"},{"issue":"1","key":"e_1_3_3_22_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/bjh.17726","article-title":"Merozoites phagocytosed by neutrophils in Plasmodium falciparum malaria","volume":"196","author":"Barros Pinto MP","year":"2022","unstructured":"Barros Pinto MP, Melo CJ. Merozoites phagocytosed by neutrophils in Plasmodium falciparum malaria. Br J Haematol. 2022;196(1):9.","journal-title":"Br J Haematol"},{"key":"e_1_3_3_23_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cimid.2019.101356","article-title":"Interleukin 17 (IL-17) manipulates mouse bone marrow-derived neutrophils in response to acute lung inflammation","volume":"67","author":"Chuammitri P","year":"2019","unstructured":"Chuammitri P, Wongsawan K, Pringproa K, Thanawongnuwech R. Interleukin 17 (IL-17) manipulates mouse bone marrow-derived neutrophils in response to acute lung inflammation. Comp Immunol Microbiol Infect Dis. 2019;67:Article 101356.","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14282"},{"issue":"10","key":"e_1_3_3_25_2","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.4049\/jimmunol.165.10.5814","article-title":"IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells","volume":"165","author":"Witowski J","year":"2000","unstructured":"Witowski J, Pawlaczyk K, Breborowicz A, Scheuren A, Kuzlan-Pawlaczyk M, Wisniewska J, Polubinska A, Friess H, Gahl GM, Frei U, et al. IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells. J Immunol. 2000;165(10):5814\u20135821.","journal-title":"J Immunol"},{"issue":"6","key":"e_1_3_3_26_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): An overview","volume":"29","author":"Deshmane SL","year":"2009","unstructured":"Deshmane SL, Kremlev S, Amini S, Sawaya BE. Monocyte chemoattractant protein-1 (MCP-1): An overview. J Interf Cytokine Res. 2009;29(6):313\u2013326.","journal-title":"J Interf Cytokine Res"},{"issue":"1","key":"e_1_3_3_27_2","first-page":"S5","article-title":"Clinical trials of artemisinin and its derivatives in the treatment of malaria in China","volume":"88","author":"Li GQ","year":"1994","unstructured":"Li GQ, Guo XB, Fu LC, Jian HX, Wang XH. Clinical trials of artemisinin and its derivatives in the treatment of malaria in China. Trans R Soc Trop Med Hyg. 1994;88(Suppl 1):S5\u2013S6.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-127837"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200385"},{"issue":"5","key":"e_1_3_3_30_2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00018-003-3228-z","article-title":"Interleukin-17: A mediator of inflammatory responses","volume":"61","author":"Witowski J","year":"2004","unstructured":"Witowski J, Ksi\u0105\u017cek K, J\u00f6rres A. Interleukin-17: A mediator of inflammatory responses. Cell Mol Life Sci. 2004;61(5):567\u2013579.","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"e_1_3_3_31_2","first-page":"145","article-title":"International union of pharmacology. XXII. Nomenclature for chemokine receptors","volume":"52","author":"Murphy PM","year":"2000","unstructured":"Murphy PM, Baggiolini M, Charo IF, H\u00e9bert CA, Horuk R, Matsushima K, Miller LH, Oppenheim JJ, Power CA. International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev. 2000;52(1):145\u2013176.","journal-title":"Pharmacol Rev"},{"issue":"8","key":"e_1_3_3_32_2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.it.2010.05.006","article-title":"Neutrophil kinetics in health and disease","volume":"31","author":"Summers C","year":"2010","unstructured":"Summers C, Rankin SM, Condliffe AM, Singh N, Peters AM, Chilvers ER. Neutrophil kinetics in health and disease. Trends Immunol. 2010;31(8):318\u2013324.","journal-title":"Trends Immunol"},{"issue":"6","key":"e_1_3_3_33_2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/ni.1736","article-title":"A protective function for interleukin 17A in T cell-mediated intestinal inflammation","volume":"10","author":"O\u2019connor W","year":"2009","unstructured":"O\u2019connor W Jr, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK, Flavell RA. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol. 2009;10(6):603\u2013609.","journal-title":"Nat Immunol"},{"issue":"1","key":"e_1_3_3_34_2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13287-019-1301-2","article-title":"BMP2 secretion from hepatocellular carcinoma cell HepG2 enhances angiogenesis and tumor growth in endothelial cells via activation of the MAPK\/p38 signaling pathway","volume":"10","author":"Feng PC","year":"2019","unstructured":"Feng PC, Ke XF, Kuang HL, Pan LL, Ye Q, Wu JB. BMP2 secretion from hepatocellular carcinoma cell HepG2 enhances angiogenesis and tumor growth in endothelial cells via activation of the MAPK\/p38 signaling pathway. Stem Cell Res Ther. 2019;10(1):237.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"e_1_3_3_35_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/s12967-019-2077-y","article-title":"The protective role of microRNA-21 against coxsackievirus B3 infection through targeting the MAP2K3\/P38 MAPK signaling pathway","volume":"17","author":"He F","year":"2019","unstructured":"He F, Xiao Z, Yao H, Li S, Feng M, Wang W, Liu Z, Liu Z, Wu J. The protective role of microRNA-21 against coxsackievirus B3 infection through targeting the MAP2K3\/P38 MAPK signaling pathway. J Transl Med. 2019;17(1):335.","journal-title":"J Transl Med"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2507"},{"issue":"1","key":"e_1_3_3_37_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1165\/rcmb.2002-0289OC","article-title":"Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor-induced adhesion molecule expression on eosinophils by p38 mitogen-activated protein kinase and nuclear factor-\u03baB","volume":"29","author":"Wong CK","year":"2003","unstructured":"Wong CK, Ip WK, Lam CW. Interleukin-3, -5, and granulocyte macrophage colony-stimulating factor-induced adhesion molecule expression on eosinophils by p38 mitogen-activated protein kinase and nuclear factor-\u03baB. Am J Respir Cell Mol Biol. 2003;29(1):133\u2013147.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803905200"},{"key":"e_1_3_3_39_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13578-019-0315-x","article-title":"CXCR4 knockdown prevents inflammatory cytokine expression in macrophages by suppressing activation of MAPK and NF-\u03baB signaling pathways","volume":"9","author":"Tian X","year":"2019","unstructured":"Tian X, Xie G, Xiao H, Ding F, Bao W, Zhang M. CXCR4 knockdown prevents inflammatory cytokine expression in macrophages by suppressing activation of MAPK and NF-\u03baB signaling pathways. Cell Biosci. 2019;9:55.","journal-title":"Cell Biosci"},{"issue":"9","key":"e_1_3_3_40_2","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1172\/JCI5208","article-title":"Chronic inflammation upregulates chemokine receptors and induces neutrophil migration to monocyte chemoattractant protein-1","volume":"103","author":"Johnston B","year":"1999","unstructured":"Johnston B, Burns AR, Suematsu M, Issekutz TB, Woodman RC, Kubes P. Chronic inflammation upregulates chemokine receptors and induces neutrophil migration to monocyte chemoattractant protein-1. J Clin Invest. 1999;103(9):1269\u20131276.","journal-title":"J Clin Invest"},{"key":"e_1_3_3_41_2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.768813","article-title":"Neutrophil-derived IL-17 promotes ventilator-induced lung injury via p38 MAPK\/MCP-1 pathway activation","volume":"12","author":"Liao X","year":"2021","unstructured":"Liao X, Zhang W, Dai H, Jing R, Ye M, Ge W, Pei S, Pan L. Neutrophil-derived IL-17 promotes ventilator-induced lung injury via p38 MAPK\/MCP-1 pathway activation. Front Immunol. 2021;12:Article 768813.","journal-title":"Front Immunol"},{"issue":"5","key":"e_1_3_3_42_2","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s11427-019-9550-4","article-title":"Dihydroartemisinin regulates the immune system by promotion of CD8+ T lymphocytes and suppression of B cell responses","volume":"63","author":"Zhang T","year":"2020","unstructured":"Zhang T, Zhang Y, Jiang N, Zhao X, Sang X, Yang N, Feng Y, Chen R, Chen Q. Dihydroartemisinin regulates the immune system by promotion of CD8+ T lymphocytes and suppression of B cell responses. Sci China Life Sci. 2020;63(5):737\u2013749.","journal-title":"Sci China Life Sci"}],"container-title":["Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.34133\/research.0559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T20:44:20Z","timestamp":1734641060000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.34133\/research.0559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":41,"alternative-id":["10.34133\/research.0559"],"URL":"https:\/\/doi.org\/10.34133\/research.0559","relation":{},"ISSN":["2639-5274"],"issn-type":[{"value":"2639-5274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-22","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"0559"}}