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Here, we present a novel acoustically transmitted decellularized fish swim bladder (DFB) loaded with mesenchymal stem cells (DFB@MSCs) for TM perforation (TMP) repair. The DFB scaffolds are obtained by removing the cellular components from the original FB, which retains the collagen composition that favors cell proliferation. Benefitting from their spatially porous structures and excellent mechanical properties, the DFB scaffolds can provide a suitable microenvironment and mechanical support for cell growth and tissue regeneration. In addition, by loading mesenchymal stem cells on the DFB scaffolds, the resultant DFB@MSCs system exhibits remarkable anti-fibrotic and anti-inflammatory effects, together with the ability to promote cell migration and angiogenesis. In\u00a0vivo experiments confirm that the prepared DFB@MSCs scaffolds can not only alleviate inflammatory response caused by TMP but also promote new vessel formation, TM repair, and hearing improvement. These features indicate that our proposed DFB@MSCs stent is a prospective tool for the clinical repair of TM.<\/jats:p>","DOI":"10.34133\/research.0596","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T15:34:08Z","timestamp":1736782448000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["Acoustic Transmitted Decellularized Fish Bladder for Tympanic Membrane Regeneration"],"prefix":"10.34133","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-2012","authenticated-orcid":false,"given":"Hong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Research Institute of Otolaryngology, Jiangsu Provincial Key Medical Discipline, \rNanjing University Medical School, Nanjing 210008, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Technology, \rSoutheast University, Nanjing 210096, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Research Institute of Otolaryngology, Jiangsu Provincial Key Medical Discipline, \rNanjing University Medical School, Nanjing 210008, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Medical College, \rYangzhou University, Yangzhou 225001, Jiangsu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Research Institute of Otolaryngology, Jiangsu Provincial Key Medical Discipline, \rNanjing University Medical School, Nanjing 210008, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoli","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery &amp; Audiology and Neurotology, Karolinska University Hospital, \rKarolinska Institute, 171 76 Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Research Institute of Otolaryngology, Jiangsu Provincial Key Medical Discipline, \rNanjing University Medical School, Nanjing 210008, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Research Institute of Otolaryngology, Jiangsu Provincial Key Medical Discipline, \rNanjing University Medical School, Nanjing 210008, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-4000","authenticated-orcid":true,"given":"Yuanjin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Research Institute of Otolaryngology, Jiangsu Provincial Key Medical Discipline, \rNanjing University Medical School, Nanjing 210008, China."},{"name":"School of Life Sciences and Technology, \rSoutheast University, Nanjing 210096, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"issue":"7659","key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1038\/546S5a","article-title":"Eardrum regeneration: Membrane repair","volume":"546","author":"Holmes D","year":"2017","unstructured":"Holmes D. 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